The anatomical study on the rat pancreas and its ducts with emphasis on the surgical approach

Kara, Mehmet Erkut

doi:10.1016/j.aanat.2004.10.004

Cited by 27 publications

(33 citation statements)

References 17 publications

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“…In fact such compact type also recorded previously in some animal such as hamster, dogs, monkeys and humans 8 . Whereas, differently was found diffused in animals such as rabbit 7 , mouse 8 , Wister rats and Sprague-Dawley rats 9 .…”

Section: Discussionmentioning

confidence: 97%

“…These findings were parallel with those found previously in different species of rabbit 7,10,14 . The presence of main pancreatic duct in domestic cats was similarly recorded in the other laboratory species such as mice, rats, guinea pigs and hamster 9,[15][16][17] . Similarly to the cat pancreas, the main duct was recorded in sheep and goats but differently these animals have also accessory duct 18 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Postnatal developmental Histomorphological and histochemical study of the pancreas in the domestic cat (Felis Catus).

Saffar¹,

Zuhairy.²

2017

IJAR

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Objective: The present study was conducted to investigate the histomorphological and histochemical postnatal developmental changes established in the pancreas of the domestic cats. Methodology: the study conducted on three different postnatal ages that were one week (suckling kittens), 4-6 weeks (weaned immature cats) and adult of one year and up cats. Macromorphometric measurements of pancreas were conducted and listed in tables. Histological sections prepared and stained by general and special stains. Results: Gross findings revealed that the pancreas of cat was of compact type, of two lobes connected by small central part. Critical macromorphometric changes observed at 4 weeks aged cats. The organ drains the pancreatic secretion toward the duodenum via main pancreatic duct. Exocrine portion more developed after birth than the endocrine portion; however both were faced developmental changes. The parenchyma provided with well duct system even in kitten. Ducts were surrounded by smooth muscle fibers invested in the connective tissue. Endocrine portion showed in kittens predominant α cells. Critical changes occurred at 4 weeks of age caused an increase of the number of ß cells so that the ratio of α / ß was changed. In adult cats the percentage of ß was predominant. In all studied ages of cats, the findings revealed the presence of well developed autonomic innervations represented by the presence of large autonomic ganglion, intramural ganglia and large sized Pacinian corpuscles. Conclusions: It could be concluded that pancreas was not fully developed at birth and weaning period caused critical development.Copy Right, IJAR, 2017,. All rights reserved. …………………………………………………………………………………………………….... Significance of the study:The significance of the current findings can be categorized into two criteria. First of all, it was first investigation focused on the development of the pancreas postnatally of the domestic cats in veterinary field. The second criteria, as the pancreas of the cats showed morphological similarities to those of human especially the presence of Pacinian ISSN: 2320-5407Int. J. Adv. Res. 5(2), 55-71 56 corpuscles, presence and distribution of α and β cells in the islets of Langerhans, such findings will be beneficial for public health and animal health and welfare.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Postnatal developmental Histomorphological and histochemical study of the pancreas in the domestic cat (Felis Catus).

Saffar¹,

Zuhairy.²

2017

IJAR

View full text Add to dashboard Cite

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“…The duct system is quite polymorphic and represented by numerous independent pancreatic ducts which drain secretion from each corresponding part. The results of pancreatectomy in rat were not always followed by the rapid onset of the diabetes and do not reflect entirely the diabetes in humans, these being speculated by those who consider that larger species are more appropriate for diabetes study [8,9].…”

Section: Experimentally Induced Hyperglycemiamentioning

confidence: 99%

Development of Improved Animal Models for the Study of Diabetes

Ciobotaru¹

2013

Diabetes Mellitus - Insights and Perspectives

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“…In addition to these major ducts, a number of minor ducts that drain all three portions of pancreas open directly to the bile duct. 6 …”

Section: Rat Biliary Anatomymentioning

confidence: 99%

Creation of Reversible Cholestatic Rat Model

Subhas

Bhullar

Mittal

et al. 2011

JoVE

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Cholestasis is a clinical condition commonly encountered by both surgeons and gastroenterologists. Cholestasis can cause various physiological changes and affect the nutritional status and surgical outcomes. Study of the pathophysiological changes occurring in the liver and other organs is of importance. Various studies have been done in cholestatic rat models.We used a reversible cholestatic rat model in our recent study looking at the role of methylprednisolone in the ischemia reperfusion injury. Various techniques for creation of a reversible cholestatic model have been described. Creation of a reversible cholestatic rat model can be challenging in view of the smaller size and unique hepatopancreatobiliary anatomy in rats. This video article demonstrates the creation of a reversible cholestatic model. This model can be used in various studies, such as looking at the changes in nutritional, physiological, pathological, histological and immunological changes in the gastrointestinal tract. This model can also be used to see the effects of cholestasis and various therapeutic interventions on major hepatic surgeries. Protocol Rat biliary anatomyThe average bile duct diameter and length was 1 mm and 29 mm, respectively. The average distance between the pylorus and the duodenal papilla was 28 mm. There are two main pancreatic ducts which open into the bile duct -the anterior duct opens on the left side and the posterior duct opens on the right side. In addition to these major ducts, a number of minor ducts that drain all three portions of pancreas open directly to the bile duct. 6 TechniqueAll animal experiments were performed in agreement with the National Institutes of Health guidelines for ethical research and were approved by the institution's Research Committee and Animal Care Committee. Male Sprague-Dawley rats aged 8 weeks were used for this demonstration. The rats were obtained from Charles River Laboratories in Wilmington, MA and all were over 300 grams. Rats had access to standard laboratory diet and were housed together in standard laboratory conditions. Rats were initially anesthetized with isofluorane and kept under anesthesia during surgery with isofluorane through a mask. A midline incision of 2 cm was made starting from the xiphisternum. Once the fascia was opened, the liver lobes were retracted cranially with a Sen's retractor, and the duodenum was retracted caudally using Q-tips. The bile duct was identified as a tubular structure entering the duodenum. The bile duct was placed under tension and partially cut open. A sterile 5 cm long polyethylene tube with an inner diameter of 0.6 mm and an outer diameter of 0.9 mm was used. One end of this tube was heat sealed and the other end was gently beveled. The beveled end was then passed into the bile duct. This was secured in place using 8-0 Nylon sutures both proximal and distal to the opening in the bile duct. The remaining tube along with the sealed end was placed in the peritoneal cavity. The operative site was irrigated with normal saline. T...

show abstract

The anatomical study on the rat pancreas and its ducts with emphasis on the surgical approach

Cited by 27 publications

References 17 publications

Postnatal developmental Histomorphological and histochemical study of the pancreas in the domestic cat (Felis Catus).

Postnatal developmental Histomorphological and histochemical study of the pancreas in the domestic cat (Felis Catus).

Development of Improved Animal Models for the Study of Diabetes

Creation of Reversible Cholestatic Rat Model

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