The Anatomy of the Lymphatic System

Abstract

Dr KLEIN has now published the second part of his work on the Lymphatic System, which like the first part is based on researches undertaken for the Medical Department of the Privy Council. In the first chapter he describes the endothelium of the pulmonary pleura, and points out that during inspiration the endothelial cells are flattened, because the lung is then distended, whilst during expi

Anatomic and functional evaluation of the lymphatics and lymph nodes in diagnosis of lymphatic circulation disorders with contrast magnetic resonance lymphangiography

“…Nodal imaging in nonmalignant lymphostatic diseases has been described in a few reports, and enhanced MR lymphangiography has proved useful for the diagnosing and staging of malignant lymph nodes. [5][6][7][8]11 The present study shows the usefulness of contrast MR lymphangiography in detecting morphologic and functional abnormalities of draining lymph nodes in benign lymphatic disorders. This included highlighting of the medullar region first, which is the opposite of normal intranodal lymph flow, and enhancement of marginal sinuses regions with central filling defects.…”

“…Flow resistance is 100 times greater in the lymph nodes than in the lymph collectors. 8 Lymphatic circulation disorders may be caused solely by lymph node abnormalities, by a lymphatic vessel problem, or a combination of lymphatic and lymph node abnormalities. 9,10 However, the influence of nodal factors on peripheral lymph flow failure remains unclear.…”

Pharmacokinetics, Lymph Node Uptake, and Mechanistic PK Model of Near-Infrared Dye-Labeled Bevacizumab After IV and SC Administration in Mice

“…Our estimate may represent an underestimate of the extent of lymphatic absorption, if any of the lymph vessels draining the SC site of injection bypass the lymph nodes. Although this remains a possibility, generally for lymph nodes present in the periphery, such as the axillary lymph nodes that drain the front forearm in the mouse, afferent lymph vessels will empty lymph into the marginal sinus of the lymph nodes and efferent lymph vessels will carry lymph away from the nodes (28,29). Additionally, our finding of limited uptake of proteins by the lymphatic system in the mouse is consistent with reported data for bovine serum albumin in our mouse model (30) and for lymphatic uptake in the rat (7,8).…”

Drainage of the Prelymphatics of the Brain via the Adventitia of the Vertebral Artery

“…Obviously, different regions of the brain drain via dif ferent paths, just as do different regions of other parts of the body (e.g. the skin [13]). This is not to say that one part of the prelymphatic system might not take over the func tions of another, to some extent, as occurs with the true lymphatic system.…”