The andrologist's contribution to a better life for ageing men: part 1

Comhaire, Frank; Mahmoud, Ahmed

doi:10.1111/and.12485

Cited by 4 publications

(3 citation statements)

References 65 publications

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“…He too was found to present a low testosterone concentration due to the "late onset hypogonadism" (LOH) syndrome [21,22]. Substitution treatment with injections of testosterone undecanoate restored his androgen status, but failed to improve his brain function.…”

Section: Resultsmentioning

confidence: 99%

A Novel Nutriceutical Treatment of Myalgic Encephalitis/Chronic Fatigue Syndrome (ME/CFS): “What it is and what it is not”

Comhaire¹

2017

Intern Med

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Ten patients suffering from pathology considered to be refractory ME/CFS have been prospectively offered treatment with a novel nutriceutical that increases the activity of pyruvate dehydrogenase and enhances mitochondrial energy production by the aerobic metabolism of the Kreb's cycle. Whereas half of the patients presented highly significant improvement of their health and condition, the other half did not experience any benefit. The latter patients were found to suffer from different pathology that should be classified as "ME/CFS-nondisease".

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Section: Resultsmentioning

confidence: 99%

A Novel Nutriceutical Treatment of Myalgic Encephalitis/Chronic Fatigue Syndrome (ME/CFS): “What it is and what it is not”

Comhaire¹

2017

Intern Med

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“…The biological mechanisms involved in the ageing process are multiple. Prevention of (precocious) ageing includes hormone replacement therapy whenever indicated [82,83], a healthy life style, and adequate nutrition. In addition, intellectual challenges and friendly social contacts exert a beneficial influence.…”

Section: Discussionmentioning

confidence: 99%

Can the biological mechanisms of ageing be corrected by food supplementation. The concept of health care over sick care

Comhaire

Decleer²

2020

The Aging Male

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From care for the sick to care for health" implies that age-related diseases and discomforts, which impair the quality of life, should be prevented rather than treated. Healthy lifestyle and nutrition, and hormone supplementationwhen neededare of crucial importance. Food supplementation with nutraceuticals composed of vitamins, oligo-minerals, plant extracts and essential amino-and fatty acids should reduce age-related oxidative and epigenetic damage to DNA, and inhibit inflammatory and metabolic impairment. This study of the potential beneficial effects of novel nutraceuticals on the biological mechanisms of physical and mental ageing suggests these supplements may be scientifically justified. In the absence of adverse side effects and the expected favourable effect on the quality-adjusted life years, the benefit over risk ratio of nutraceutical supplementation should be positive.

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“…The content of vitamin C in human seminal plasma is approximately 10-fold that in serum. The concentration of vitamin C is reported to be positively correlated with the percentage of normal sperm and negatively correlated with DFI [ 80 ]. Clinical studies have found that oral vitamin C administered at the dosage of 1 g/day can effectively treat male infertility [ 81 ].…”

Section: The Application Of Antioxidants In the Treatment Of Male Inf...mentioning

confidence: 99%

Age-Related Decline of Male Fertility: Mitochondrial Dysfunction and the Antioxidant Interventions

Wang

Tehmina

et al. 2022

Pharmaceuticals

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Mitochondria are structurally and functionally unique organelles in male gametes. Apparently, as the only organelles remaining in mature sperm, mitochondria not only produce adeno-sine triphosphate (ATP) through oxidative phosphorylation (OXPHOS) to support sperm mobility, but also play key roles in regulating reactive oxidation species (ROS) signaling, calcium homeostasis, steroid hormone biosynthesis, and apoptosis. Mitochondrial dysfunction is often associated with the aging process. Age-dependent alterations of the epididymis can cause alterations in sperm mitochondrial functioning. The resultant cellular defects in sperm have been implicated in male infertility. Among these, oxidative stress (OS) due to the overproduction of ROS in mitochondria may represent one of the major causes of these disorders. Excessive ROS can trigger DNA damage, disturb calcium homeostasis, impair OXPHOS, disrupt the integrity of the sperm lipid membrane, and induce apoptosis. Given these facts, scavenging ROS by antioxidants hold great potential in terms of finding promising therapeutic strategies to treat male infertility. Here, we summarize the progress made in understanding mitochondrial dysfunction, aging, and male infertility. The clinical potential of antioxidant interventions was also discussed.

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The andrologist's contribution to a better life for ageing men: part 1

Cited by 4 publications

References 65 publications

A Novel Nutriceutical Treatment of Myalgic Encephalitis/Chronic Fatigue Syndrome (ME/CFS): “What it is and what it is not”

A Novel Nutriceutical Treatment of Myalgic Encephalitis/Chronic Fatigue Syndrome (ME/CFS): “What it is and what it is not”

Can the biological mechanisms of ageing be corrected by food supplementation. The concept of health care over sick care

Age-Related Decline of Male Fertility: Mitochondrial Dysfunction and the Antioxidant Interventions

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