The anemia of chronic disease: Spectrum of associated diseases in a series of unselected hospitalized patients

Cash, Joseph M.; Sears, David

doi:10.1016/0002-9343(89)90723-7

Cited by 28 publications

(37 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Microcytic anaemia alone is not sufficient to diagnose iron deficiency, especially in elderly patients (3 20% of elderly patients with a mean cell volume < 75 fl will not be iron deficient)…”

Section: Casementioning

confidence: 99%

Investigating iron status in microcytic anaemia

Galloway

Smellie

2006

BMJ

View full text Add to dashboard Cite

Section: Casementioning

confidence: 99%

Investigating iron status in microcytic anaemia

Galloway

Smellie

2006

BMJ

View full text Add to dashboard Cite

“…It is traditionally associated with chronic infections, inflammatory and neoplastic diseases, but similar features are also seen in critically ill patients in intensive care, in post-operative patients, and in patients following severe trauma. [47][48][49][50] It has been shown that various cytokines, including tumour necrosis factor and interleukin-1, are increased in patients with ACD; it is believed that these cytokines are involved in the three major processes that lead to ACD (Figure 4). 51 Hepcidin is a peptide that has recently been linked to the pathogenesis of ACD.…”

Section: Anaemia Of Chronic Diseasementioning

confidence: 99%

Identification and treatment of anaemia in older patients

Osborne

Pemberton

Hanley

2006

Rev. Clin. Gerontol.

View full text Add to dashboard Cite

The World Health Organization's definition of anaemia is a haemoglobin level of less than 13g/dL for men and less than 12g/dL for women. Haemoglobin levels have been shown to decline with age, making anaemia a relatively common problem among older people. Because of this fall in haemoglobin with age, there has been some debate about whether an age-related reference range should be used. However, most clinicians believe that, because of the association between anaemia and increased risk of morbidity, mortality and hospitalization, the normal haemoglobin range should not be lowered for older people.

show abstract

“…Furthermore, patients with ACD often have an inappropriate low erythropoietin serum level as related to the degree of anemia, and hypoerythropoietinemia contributes to the development of anemia in these patients [73]. In patients with ACD, the survival of erythrocytes is shortened to approximately 60-90 days [17]. ACD is present in more than 50% of patients with hematological malignancies who were evaluated in a public hospital [17].…”

Section: Pathophysiology Of Cancer-related Anemiamentioning

confidence: 99%

“…In patients with ACD, the survival of erythrocytes is shortened to approximately 60-90 days [17]. ACD is present in more than 50% of patients with hematological malignancies who were evaluated in a public hospital [17]. According to this, three mechanisms are responsible for ACD: Impaired iron utilization, suppression of erythroid progenitor cells, and an inadequate erythropoietin production.…”

Section: Pathophysiology Of Cancer-related Anemiamentioning

confidence: 99%

Recombinant human erythropoietin in the treatment of anemic patients with hematological malignancies

Kasper

2001

Annals of Hematology

View full text Add to dashboard Cite

Patients with malignant diseases frequently develop anemia. An alternative to blood transfusions is the application of recombinant human erythropoietin. Several nonrandomized and prospective, placebo-controlled studies have demonstrated the effect and safety of erythropoietin in patients with hematological malignancies, particularly in patients with multiple myeloma and low- to intermediate-grade non-Hodgkin's lymphoma. However, in patients with myelodysplastic syndromes, the rather low response rate of erythropoietin is overcome by the combination of erythropoietin with granulocyte colony-stimulating factor. A significant acceleration of the reconstitution of erythropoiesis has been reported in allogeneic, but not in autologous bone marrow transplantation. Especially in large open-label, multicenter studies, a statistically and clinically significant improvement in quality of life independent from chemotherapeutic response or tumor type has been demonstrated. A number of simple algorithms have been proposed using the pretreatment serum erythropoietin level, transfusion requirements, and early changes in hematological parameters.

show abstract

The anemia of chronic disease: Spectrum of associated diseases in a series of unselected hospitalized patients

Cited by 28 publications

References 0 publications

Investigating iron status in microcytic anaemia

Investigating iron status in microcytic anaemia

Identification and treatment of anaemia in older patients

Recombinant human erythropoietin in the treatment of anemic patients with hematological malignancies

Contact Info

Product

Resources

About