The angiogenesis-modulating effects of coumarin-derivatives

Huang, Han-Ting; Huang, Ching-Yuan; Lee, Chih-Jou; Sun, Bo-Jie; Jhang, Zong-Wei; Wen, Chi-Chung; Wang, Yun-Hsin; Li, Tao-Sheng; Chern, Ching-Yuh; Chen, Yau-Hung

doi:10.1016/j.cbpc.2024.109862

Comparative Biochemistry and Physiology Part C: Toxicology &amp

2024

DOI: 10.1016/j.cbpc.2024.109862

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The angiogenesis-modulating effects of coumarin-derivatives

Han-Ting Huang,

Ching-Yuan Huang,

Chih-Jou Lee

et al.

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Pro-angiogenic effects of Guo Min decoction in a zebrafish model

Lu,

Tung,

Wen

et al. 2024

Tzu Chi Medical Journal

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Objectives: Guo Min decoction (GMD) is a Chinese traditional medicine that can regulate allergy-related symptoms. Although GMD treatment was reported to treat allergy-associated symptoms by regulating the immune response, the rationale between GMD treatment and angiogenesis has not been reported yet. Our objective is to investigate the angiogenesis-modulating activity of GMD. Materials and Methods: In this study, we used fluorescence recording, alkaline phosphatase (AP) activity staining, and real-time polymerase chain reaction (PCR) experiments to examine the effects of GMD on angiogenesis in a zebrafish model. Results: GMD-treated zebrafish embryos exhibited more intercapillary spaces in the caudal vein plexus (Mock: 11.1 ± 1.8 [n = 20; n: numbers of embryos]; GMD-treated: 16.2 ± 1.9 [n = 20]). AP activity staining showed that treatment with GMD and liquorice (Gan Cao, a component of GMD) induced subintestinal vein outgrowth. However, glycyrrhizin (a component of Gan Cao) had no obvious pro-angiogenic effects on zebrafish. Furthermore, real-time PCR experiments indicated that GMD exposure might be through regulating angiogenesis-related genes (cdh5, nrp1a, and flt1) expressions. Conclusion: Based on these observations, we proposed that GMD had pro-angiogenic activity in a zebrafish model, and it might partially be contributed by one of the components, liquorice.

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Pro-angiogenic effects of Guo Min decoction in a zebrafish model

Lu,

Tung,

Wen

et al. 2024

Tzu Chi Medical Journal

View full text Add to dashboard Cite

show abstract

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The angiogenesis-modulating effects of coumarin-derivatives

Cited by 1 publication

References 32 publications

Pro-angiogenic effects of Guo Min decoction in a zebrafish model

Pro-angiogenic effects of Guo Min decoction in a zebrafish model

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