The Angiogenetic Effect of Resveratrol on Dermal Wound Healing in Balb/C Mice

Afshar, Mohammad; Hassanzadeh-Taheri, Mohammadmehdi; Zardast, Mahmoud; Moghaddam, Asma

doi:10.5812/modernc.66118

Cited by 13 publications

(19 citation statements)

References 32 publications

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“…To our knowledge, collagen depositions and angiogenesis promote the tensile strength and play an important role in wound healing. 7,24 Although the exact cellular mechanisms by which RSV enhances tensile strength are unclear, the present study showed that stimulation of neovascularization and increase in collagen deposition are of a significant importance.…”

Section: Discussionmentioning

confidence: 59%

“…25 In the present study, we showed that neovascularization scores significantly increased on PODs 14 and 21 in the local RSV treatment group compared with those in the systemic RSV and control groups. Afshar et al 24 also showed that the high granulation at a wound tissue due to high VEGF expression accelerated wound healing. Similar to that in the Afshar et al 24 study, the granulation scores in the present study were higher in the systemic and local RSV treatment groups than in the control group.…”

Section: Discussionmentioning

confidence: 99%

“…Afshar et al 24 also showed that the high granulation at a wound tissue due to high VEGF expression accelerated wound healing. Similar to that in the Afshar et al 24 study, the granulation scores in the present study were higher in the systemic and local RSV treatment groups than in the control group.…”

Section: Discussionmentioning

confidence: 99%

“…Neovascularization is a fundamental process in wound healing. 7 Afshar et al 24 evaluated the angiogenetic effect of topically administrated RSV on dermal wound healing in Balb/C mice. Their study showed that topical administration of RSV increased the expression of vascular endothelial growth factor (VEGF) in a concentration-dependent manner compared with that in the control and sham groups.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of the Effect of Local and Systemic Injection of Resveratrol on Cutaneous Wound Healing in Rats

Bilgiç

2020

The International Journal of Lower Extremity Wounds

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Purpose. To compare the effect of local and systemic injection of resveratrol (RSV) on open cutaneous wound healing. Materials and Methods. Open cutaneous wounds were created in adult Sprague–Dawley rats. Group 1 (n = 6) was given intraperitoneal RSV (0.5 mg/kg) once daily for 14 days. Group 2 (n = 6) was given local subcutaneous RSV (0.5 mg/kg) on the wound once daily for 14 days. Group 3 (n = 6) did not receive any pharmacologic agent. Biopsy specimens were obtained on postoperative days (PODs) 7, 14, and 21 and were examined histologically. Wound closure time was recorded. All rats were sacrificed on POD 30 for tensile strength analysis. Results. The histological scores for collagen deposition, chronic inflammation, and granulation were higher in the systemic and local RSV treatment groups than in the control group. Neovascularization scores significantly increased on PODs 14 and 21 in the local RSV treatment group compared with those in the systemic RSV and control groups. Systemic and local RSV administrations significantly enhanced wound healing and increased the tensile strength of the skin in rats. Conclusion. Local subcutaneous application of RSV may have a better therapeutic effect than the systemic application of RSV in terms of neovascularization to promote wound healing.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Comparison of the Effect of Local and Systemic Injection of Resveratrol on Cutaneous Wound Healing in Rats

Bilgiç

2020

The International Journal of Lower Extremity Wounds

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“…For this purpose, a dorsal wound was created in 60 rodents and then divided into 5 groups, of which 4 were control groups and 1 was supplemented with resveratrol at a concentration of 0.05% and 0.1% (administration twice a day) lasting for 2 weeks. At the end of the experiment, it was found that the polyphenol caused an increase in the concentration and activity of vascular endothelial growth factor (VEGF) and the wounds in the polyphenol treated group healed faster than in other rodents, as well as the angiogenesis processes were more prominent in this study group [ 30 ].…”

Section: Skin Regenerationmentioning

confidence: 99%

Resveratrol as a factor preventing skin aging and affecting its regeneration

Leis¹,

Pisanko²,

Jundziłł³

et al. 2022

pdia

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Resveratrol, a compound belonging to polyphenols, besides its action on the cardiovascular system, affects also wound healing, regeneration, and photoaging of the skin. By interactions with numerous substances and pathways, e.g. MAPK, MAPKK, FOXO3, TGF or metalloproteinase 1, it protects the skin against the harmful effects of type B ultraviolet radiation, which is the main factor in the skin aging processes. It also enhances collagen synthesis by activating the oestrogen receptor and reduces wrinkles. In damaged tissues, it accelerates skin regeneration and healing by activating, among others, VEGF. Based on the review of the literature, there is no doubt that resveratrol has the potential to be used in cosmetology, dermatology and plastic surgery. It can be used as a compound of anti-aging products or as a topical treatment of scars and wounds. In the future this polyphenol might be applied in pharmacotherapy of many dermatoses.

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