2014
DOI: 10.1155/2014/683757
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The Angiogenic Activity of Ascites in the Course of Ovarian Cancer as a Marker of Disease Progression

Abstract: Ovarian cancer cells are able to create invasive implants in the peritoneum and their growth is directly associated with the angiogenetic potential. This effect is probably stimulated by vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8), which are both found in ascites. The aim of this study was to assess the influence of ascites produced by ovarian cancer on the angiogenesis. Peritoneal fluid was collected from patients with advanced ovarian cancer; cancer cells were separated from CD45+ leuk… Show more

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Cited by 15 publications
(12 citation statements)
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“…Additionally CR mice showed decreased VEGF levels, more significantly in the ascites, in concordance with findings from other studies [78]. High VEGF levels, especially in the ascites, are characteristics of ovarian cancer [79, 80]. Overall our data extends the antitumor effects of CR in ovarian cancer and supports its application as a noninvasive adjunct approach towards management of ovarian cancer.…”
Section: Discussionsupporting
confidence: 91%
“…Additionally CR mice showed decreased VEGF levels, more significantly in the ascites, in concordance with findings from other studies [78]. High VEGF levels, especially in the ascites, are characteristics of ovarian cancer [79, 80]. Overall our data extends the antitumor effects of CR in ovarian cancer and supports its application as a noninvasive adjunct approach towards management of ovarian cancer.…”
Section: Discussionsupporting
confidence: 91%
“…At the same time, direct evidence for the proangiogenic capabilities of malignant ascites contributing to improved tumor development is mainly speculative, as it is solely based on the identification of an increased level of angiogenic agents in this fluid [ 6 ] or on an assessment of ascites-related angiogenesis using very artificial models. The latter is the case, for example, for a study in which the proangiogenic capacity of malignant ascites was monitored using skin angiogenesis assay in mice [ 9 ].…”
Section: Resultsmentioning
confidence: 99%
“…Metastasis of adenocarcinoma is associated with migration and invasion of cancer cells [21]. On average, about 36% of cancer cells exist in ascites of patients with advanced stage of cancer [22]. Ovarian cancer cells can exist as single ones and MSC-multicellular spheroid.…”
Section: Discussionmentioning
confidence: 99%