The angiotensin-converting enzyme insertion/deletion polymorphism of vitiligo in a population in upper Egypt

Azeem, Nagwa E. Abdel; Attallah, Dalia A.; Hussein, Assmaa A.; Alzzubidi, Nawal A.S.

doi:10.1097/01.ewx.0000481054.37701.f5

Cited by 5 publications

(3 citation statements)

References 24 publications

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“…Prior research has established that populations from a particular region of the world would exhibit a similar ACE I/D polymorphism pattern to populations from another region [ 49 ]. Studies conducted among western populations in France [ 50 ], Germany [ 51 ], Egypt [ 52 ], Spain [ 53 ], and Italy [ 54 ] found that the frequency of the D allele is more dominant than the I allele, whereas studies conducted among Asian populations in India [ 55 ], Thailand [ 56 ], and Korea [ 57 ] found that the I allele frequency is more dominant than the D allele. In line with these previous studies, we discovered that the Javanese ethnicity, who were the subjects of this current study, had a dominant I allele frequency (78.6) over the D allele (21.4), and the DD genotype was less frequent than the II genotype (4.3 vs. 61.4).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Angiotensin Converting Enzyme (ACE) I/D Polymorphism on Atherosclerotic Cardiovascular Disease and Cardiovascular Mortality Risk in Non-Hemodialyzed Chronic Kidney Disease: The Mediating Role of Plasma ACE Level

Susilo

Pikir

Thaha

et al. 2022

Genes

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The association between angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphisms and plasma ACE levels may allow for the optimization of a preventive intervention to reduce cardiovascular morbidity and mortality in the chronic kidney disease (CKD) population. In this study, we aimed to analyze the association between ACE I/D polymorphism and cardiovascular mortality risk among non-hemodialyzed chronic kidney disease patients. This cross-sectional study examined 70 patients of Javanese ethnic origin with stable CKD who did not receive hemodialysis. ACE I/D polymorphisms, plasma ACE levels, atherosclerotic cardiovascular disease (ASCVD) risk, and cardiovascular mortality risk were investigated. As per our findings, the I allele was found to be more frequent (78.6) than the D allele (21.4), and the DD genotype was less frequent than the II genotype (4.3 vs. 61.4). The ACE I/D polymorphism had a significant direct positive effect on plasma ACE levels (path coefficient = 0.302, p = 0.021). Similarly, plasma ACE levels had a direct and significant positive effect on the risk of atherosclerotic cardiovascular disease (path coefficient = 0.410, p = 0.000). Moreover, atherosclerotic cardiovascular disease risk had a significant positive effect on cardiovascular mortality risk (path coefficient = 0.918, p = 0.000). The ACE I/D polymorphism had no direct effect on ASCVD and cardiovascular mortality risk. However, our findings show that the indirect effects of high plasma ACE levels may be a factor in the increased risk of ASCVD and cardiovascular mortality in Javanese CKD patients.

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Section: Discussionmentioning

confidence: 99%

The Effect of Angiotensin Converting Enzyme (ACE) I/D Polymorphism on Atherosclerotic Cardiovascular Disease and Cardiovascular Mortality Risk in Non-Hemodialyzed Chronic Kidney Disease: The Mediating Role of Plasma ACE Level

Susilo

Pikir

Thaha

et al. 2022

Genes

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“…Moreover, they demonstrated that there was no significant difference between patients associated with or without other autoimmune diseases in terms of D/D, D/I, and I/I genotypes (p=0.75) and D and I alleles (p=0.86 and p=0.29, respectively). In contrast, another Egyptian study suggested that individuals carrying the D/I genotype have a higher risk of vitiligo when compared with D/D + I/I [16]. This disagreement between both studies was most likely attributed based on the center of each study.…”

Section: Discussionmentioning

confidence: 94%

“…Title and abstract screening led to exclusion of 412 studies and the finding of 38 potential full-text articles that can be included. After the full-text screening, ten studies (n=2,740) matched the inclusion and exclusion eligibility criteria for this systematic review and meta-analysis [9,10,[14][15][16][17][18][19][20][21][22]. The study selection process is shown in the study flow diagram…”

Section: Search Resultsmentioning

confidence: 99%

Associations of Angiotensin-Converting Enzyme Gene Insertion/Deletion (ACE Gene I/D) Polymorphism With Vitiligo: An Updated Systematic Review and Meta-Analysis

Almohideb

2020

Cureus

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The objective of the article is to summarize the current evidence regarding the association between angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism and vitiligo disease. Methods A computerized search was performed through four electronic databases (PubMed, Scopus, Cochrane Central Register of Controlled Trials [CENTRAL], and Web of Science) with the relevant keywords. Included studies comprised of papers examining the association of ACE gene polymorphisms with vitiligo. Data were pooled as an odds ratio (OR) in random-and fixed-effect models using the Mantel-Haenszel (M-H) method. Review Manager 5.3 software (clicktime.com, Inc., San Francisco, US) was utilized in the meta-analysis. Results Ten studies (n=2,740) matching the inclusion criteria were included in the systematic review and meta-analysis. Results showed no significant difference between individuals carrying deletion/deletion (D/D) genotype and individuals with deletion/insertion (D/I) + insertion/insertion (I/I) genotypes in terms of vitiligo risk (odds ratio [OR]=1.13, 95% confidence interval [CI]: 0.78 to 1.64, p=0.53). However, vitiligo risk was higher in the individuals carrying the I/D genotype when compared with individuals with D/D + I/I genotypes (OR=1.29, 95% CI: 1.10 to 1.52, p=0.001). Moreover, the increased risk was observed in individuals carrying D/D when compared with I/I (OR=1.67, 95% CI: 1.33 to 2.09, p<0.0001). D allele was associated with significant risk when compared with the I allele (OR=1.29, 95% CI: 1.15 to 1.45, p<0.0001).

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Role of kinin receptors in skin pigmentation

Ferreira,

Soley,

Pawloski

et al. 2024

European Journal of Pharmacology

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The angiotensin-converting enzyme insertion/deletion polymorphism of vitiligo in a population in upper Egypt

Cited by 5 publications

References 24 publications

The Effect of Angiotensin Converting Enzyme (ACE) I/D Polymorphism on Atherosclerotic Cardiovascular Disease and Cardiovascular Mortality Risk in Non-Hemodialyzed Chronic Kidney Disease: The Mediating Role of Plasma ACE Level

The Effect of Angiotensin Converting Enzyme (ACE) I/D Polymorphism on Atherosclerotic Cardiovascular Disease and Cardiovascular Mortality Risk in Non-Hemodialyzed Chronic Kidney Disease: The Mediating Role of Plasma ACE Level

Associations of Angiotensin-Converting Enzyme Gene Insertion/Deletion (ACE Gene I/D) Polymorphism With Vitiligo: An Updated Systematic Review and Meta-Analysis

Role of kinin receptors in skin pigmentation

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