The angiotensinogen gene M235T polymorphism and acute myocardial infarction risk: a meta-analysis of 22 studies

Abstract

Angiotensinogen, one of the most important proteins in the renin-angiotensin system, plays a key role in the progress of coronary heart disease and myocardial infarction (MI). Many studies have investigated the association between angiotensinogen gene M235T polymorphism and MI risk, but the results were inconsistent. We performed a meta-analysis of 22 studies on M235T polymorphism and MI risk published before November 2012. This meta-analysis included a total of 4,606 MI cases and 4,918 controls. Overall, the per-allele odds ratio (OR) of the 235T variant for total MI risk was 1.04 (95 % CI 0.92-1.17). When a recessive model was evaluated, the OR was 1.06 (95 % CI 0.96-1.17) and under a dominant model, the OR was 0.96 (95 % CI 0.82-1.11). Under pairwise comparisons, non-significant associations were found between M235T polymorphism and MI risk (MT vs. MM, OR, 0.96, 95 % CI 0.87-1.06; TT vs. MM, OR, 1.03, 95 % CI 0.83-1.28). Subgroup analyses in the different ethnic groups and different control sources were performed and no significant association was found also. Based on the available evidence, no association between M235T polymorphism and MI risk was observed, even in the sub-analysis concerning different races and control sources. The direction of further research should focus not only on the simple relationship of M235T polymorphism and MI risk, but also on gene-gene and gene-environment interaction.

Angiotensinogen-M235T as a risk factor for myocardial infarction in Asian populations: a genetic association study and a bioinformatics approach

“…3 reports were excluded because the full-texts were not available ( 47 - 49 ). 3 other reports were excluded because they were meta-analyses ( 50 - 52 ). 2 studies did not have accessible original data ( 53 , 54 ).…”

“…Sui and Gao ( 50 ) reported no association between AGT -M235T and the MI risk, even in the subgroup analysis comprising different ethnic and control sources. However, they ( 50 ) included incorrect alleles and genotypes frequencies from 8 studies ( 29 - 32 , 36 , 39 , 40 , 43 ). Liang et al ( 51 ) and Wang and Pan ( 52 ) found an association between the polymorphism and MI risk in Asian population only.…”

“…There were 3 meta-analyses that reported erroneous data from the included studies ( 50 - 52 ). Sui and Gao ( 50 ) reported no association between AGT -M235T and the MI risk, even in the subgroup analysis comprising different ethnic and control sources. However, they ( 50 ) included incorrect alleles and genotypes frequencies from 8 studies ( 29 - 32 , 36 , 39 , 40 , 43 ).…”

Prognostic Significance of Met235/235thr Polymorphisms of Gene Agt for Development of Cardiovascular Disorders in Professional Sportsmen

“…Влияние М235Т полиморфизмов гена AGT на риск развития ССЗ в различных этнических группах отра-жено в трех крупных мета-анализах (Liang X, et al, 2013, Sui X, et al, 2013, Wang YI, et al, 2014, прове-денных независимыми авторами в период с 2013 по 2014гг. На основе 75 работ, включавших 28109 жителей Юго-Восточной Азии с подтвержденными БСК установлено, что Т235Т генотип повышает риск развития инфаркта миокарда примерно в 3 раза чаще, чем дикий М235М вариант.…”

“…На основе 75 работ, включавших 28109 жителей Юго-Восточной Азии с подтвержденными БСК установлено, что Т235Т генотип повышает риск развития инфаркта миокарда примерно в 3 раза чаще, чем дикий М235М вариант. В случае с европейцами эта закономерность не прослеживается [8][9][10].…”