The anguibactin biosynthesis and transport genes are encoded in the chromosome of <i><scp>V</scp>ibrio harveyi</i>: a possible evolutionary origin for the p<scp>JM</scp>1 plasmid–encoded system of <i><scp>V</scp>ibrio anguillarum</i>?

Naka, Hiroaki; Actis, Luis A.; Crosa, Jorge H.

doi:10.1002/mbo3.65

Cited by 17 publications

(15 citation statements)

References 44 publications

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“…These two sequenced V. harveyi strains, BAA-1116 and HY01, have been proposed to be classified as V. campbellii by microarray-based comparative genomic hybridization (CGH) and multilocus sequence analyses (MLSA) (Lin et al 2010). We also demonstrated that V. campbellii but not V. harveyi , as classified by CGH and MLSA, produces anguibactin by specific bioassay (Naka et al 2013b). Furthermore, it was also reported that V. campbellii DS40M4 produces anguibactin, and the anguibactin cluster was found in its draft genome sequence (Dias et al 2012; Sandy et al 2010).…”

Section: Chromosome-encoded Anguibactin System In V Harveyimentioning

confidence: 74%

“…V. harveyi is a marine bacterium as well, and some of the strains are pathogens that mainly affect the shrimp aquaculture industry. Two sequenced strains of V. harveyi , BAA-1116 and HY01, carry a gene cluster containing homologues of the majority of anguibactin biosynthesis and transport genes found in the pJM1 plasmid of V. anguillarum (Naka et al 2013b) (Fig. 4).…”

Section: Chromosome-encoded Anguibactin System In V Harveyimentioning

confidence: 99%

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Plasmid- and chromosome-encoded siderophore anguibactin systems found in marine vibrios: biosynthesis, transport and evolution

et al. 2013

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Vibrio anguillarum is a marine pathogen that causes vibriosis, a hemorrhagic septicemia in aquatic invertebrate as well as vertebrate animals. The siderophore anguibactin system is one of the most important virulence factors of this bacterium. Most of the anguibactin biosynthesis and transport genes are located in the 65-kb pJM1 virulence plasmid although some of them are found in the chromosome of this fish pathogen. Over 30 years of research unveiled the role numerous chromosomal and pJM1 genes play in the synthesis of anguibactin and the transport of cognate ferric complexes into the bacterial cell. Furthermore, these studies showed that pJM1-carrying strains might be originated from pJM1-less strains producing the chromosome-mediated siderophore vanchrobactin. Additionally, we recently identified a chromosome-mediated anguibactin system in V. harveyi suggesting the possible evolutional origin of the V. anguillarum anguibactin system. In this review, we present our current understanding of the mechanisms and evolution hypothesis of the anguibactin system that might have occurred in these pathogenic vibrios.

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Section: Chromosome-encoded Anguibactin System In V Harveyimentioning

confidence: 74%

Section: Chromosome-encoded Anguibactin System In V Harveyimentioning

confidence: 99%

Plasmid- and chromosome-encoded siderophore anguibactin systems found in marine vibrios: biosynthesis, transport and evolution

et al. 2013

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“…This suggests that V. anguillarum acquired the anguibactin iron transport system by horizontal transmission. Homologs of the plasmid genes are present in the chromosome of Vibrio harveyi, which also produces anguibactin, further supporting horizontal transfer of the genes (67).…”

Section: Transport Of Iron Complexesmentioning

confidence: 82%

Vibrio Iron Transport: Evolutionary Adaptation to Life in Multiple Environments

Payne

Mey

Wyckoff

2016

Microbiol Mol Biol Rev

102

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SUMMARYIron is an essential element forVibriospp., but the acquisition of iron is complicated by its tendency to form insoluble ferric complexes in nature and its association with high-affinity iron-binding proteins in the host. Vibrios occupy a variety of different niches, and each of these niches presents particular challenges for acquiring sufficient iron.Vibriospecies have evolved a wide array of iron transport systems that allow the bacteria to compete for this essential element in each of its habitats. These systems include the secretion and uptake of high-affinity iron-binding compounds (siderophores) as well as transport systems for iron bound to host complexes. Transporters for ferric and ferrous iron not complexed to siderophores are also common toVibriospecies. Some of the genes encoding these systems show evidence of horizontal transmission, and the ability to acquire and incorporate additional iron transport systems may have allowedVibriospecies to more rapidly adapt to new environmental niches. While too little iron prevents growth of the bacteria, too much can be lethal. The appropriate balance is maintained in vibrios through complex regulatory networks involving transcriptional repressors and activators and small RNAs (sRNAs) that act posttranscriptionally. Examination of the number and variety of iron transport systems found inVibriospp. offers insights into how this group of bacteria has adapted to such a wide range of habitats.

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“…A more striking discovery was the identification of an angR gene homolog in a whole-genome sequence of Vibrio harveyi (211). Further detailed analysis revealed that the chromosome of this bacterium encodes the complete ITB operon including the upstream angM gene and downstream genes angH, angU, and angN.…”

Section: Heterogeneity Of the Pjm1 Determinantsmentioning

confidence: 99%

“…Further detailed analysis revealed that the chromosome of this bacterium encodes the complete ITB operon including the upstream angM gene and downstream genes angH, angU, and angN. In the case of V. harveyi the angBG gene is located in proximity to the cluster, while on the pJM1 plasmids the two clusters are located in noncontiguous regions (211).…”

Section: Heterogeneity Of the Pjm1 Determinantsmentioning

confidence: 99%

Plasmid-Encoded Iron Uptake Systems

Lorenzo

Stork

2014

Microbiol Spectr

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Plasmids confer genetic information that benefits the bacterial cells containing them. In pathogenic bacteria, plasmids often harbor virulence determinants that enhance the pathogenicity of the bacterium. The ability to acquire iron in environments where it is limited, for instance the eukaryotic host, is a critical factor for bacterial growth. To acquire iron, bacteria have evolved specific iron uptake mechanisms. These systems are often chromosomally encoded, while those that are plasmid-encoded are rare. Two main plasmid types, ColV and pJM1, have been shown to harbor determinants that increase virulence by providing the cell with essential iron for growth. It is clear that these two plasmid groups evolved independently from each other since they do not share similarities either in the plasmid backbones or in the iron uptake systems they harbor. The siderophores aerobactin and salmochelin that are found on ColV plasmids fall in the hydroxamate and catechol group, respectively, whereas both functional groups are present in the anguibactin siderophore, the only iron uptake system found on pJM1-type plasmids. Besides siderophore-mediated iron uptake, ColV plasmids carry additional genes involved in iron metabolism. These systems include ABC transporters, hemolysins, and a hemoglobin protease. ColV-and pJM1-like plasmids have been shown to confer virulence to their bacterial host, and this trait can be completely ascribed to their encoded iron uptake systems.

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The anguibactin biosynthesis and transport genes are encoded in the chromosome of Vibrio harveyi: a possible evolutionary origin for the pJM1 plasmid–encoded system of Vibrio anguillarum?

Cited by 17 publications

References 44 publications

Plasmid- and chromosome-encoded siderophore anguibactin systems found in marine vibrios: biosynthesis, transport and evolution

Plasmid- and chromosome-encoded siderophore anguibactin systems found in marine vibrios: biosynthesis, transport and evolution

Vibrio Iron Transport: Evolutionary Adaptation to Life in Multiple Environments

Plasmid-Encoded Iron Uptake Systems

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