The ankyrin repeat protein Diversin recruits Casein kinase Iε to the β-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling

Schwarz-Romond, Thomas; Asbrand, Christian; Bakkers, Jeroen; Kühl, Michael; Schaeffer, Hans‐Joerg; Huelsken, Joerg; Behrens, Jürgen; Hammerschmidt, Matthias; Birchmeier, Walter

doi:10.1101/gad.230402

Cited by 182 publications

(152 citation statements)

References 55 publications

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“…While it is generally accepted that CK1a binds Axin and phosphorylates b-catenin at Ser45 in order to prime GSK3 phosphorylation at the more N-terminal residues (Amit et al, 2002;Liu et al, 2002;Yanagawa et al, 2002), the role of CK1e within the destruction complex is controversial. One study has proposed that CK1e binds Axin indirectly via the protein Diversin (Schwarz-Romond et al, 2002), although the absence of an Axin-binding site in the Drosophila relative of Diversin (called Diego) indicates that this is not a conserved function between invertebrates and vertebrates. Moreover, the exact role of the Diversin bound CK1e in the complex is unclear.…”

Section: Casein Kinasementioning

confidence: 99%

β-Catenin destruction complex: insights and questions from a structural perspective

2006

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At the heart of the canonical Wnt signaling pathway is the b-catenin destruction complex, which functions in the absence of Wnt signaling to keep the cytosolic and nuclear levels of b-catenin very low by promoting the phosphorylation and ubiquitination of b-catenin. Structural studies, combined with other experimental approaches, have begun to provide important insights into the mechanism of the destruction complex. We suggest a working model for the destruction complex based on the existing structural and experimental data, and focus on the questions that this model and other studies have raised about the function of the complex in both the normal and Wnt-inhibited states.

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Section: Casein Kinasementioning

confidence: 99%

β-Catenin destruction complex: insights and questions from a structural perspective

2006

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“…A ''core'' set of PCP genes was established in Drosophila (Fanto and McNeill, 2004). Homologues in vertebrates include Vangl1/ 2, Frizzled3 and 6, Disheveled1-3, Celsr1, Prickle, Scribbled, PTK7, and Ankrd6 (Schwarz-Romond et al, 2002;Carreira-Barbosa et al, 2003;Curtin et al, 2003;Montcouquiol et al, 2003;Lu et al, 2004;Wang et al, 2006a,b;Torban et al, 2007). Examples of PCP can be observed throughout vertebrate embryogenesis, most notably in the convergent extension (CE) movements required to elongate and shape the neural epithelium during early neurulation, as well as the highly organized epithelium within the cochlear sensory structures (Park and Moon, 2002;Wang et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development

Dawe

Kooistra

Fairbridge

et al. 2011

Developmental Dynamics

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The loss of Cecr2, which encodes a chromatin remodeling protein, has been associated with the neural tube defect (NTD) exencephaly and open eyelids in mice. Here, we show that two independent mutations of Cecr2 are also associated with specific inner ear defects. Homozygous mutant 18.5 days post coitus (dpc) fetuses exhibited smaller cochleae as well as rotational defects of sensory cells and extra cell rows in the inner ear reminiscent of planar cell polarity (PCP) mutants. Cecr2 was expressed in the neuroepithelium, head mesenchyme, and the cochlear floor. Although limited genetic interaction for NTDs was seen with Vangl2, a microarray analysis of PCP genes did not reveal a direct connection to this pathway. The mechanism of Cecr2 action in neurogenesis and inner ear development is likely complex.

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“…Inhibition of PCP signaling, which antagonizes Wnt/b-catenin signaling (Yan et al 2001;Schwarz-Romond et al 2002;Simons et al 2005;Li et al 2011), may also explain why sFRPs can activate Wnt/b-catenin signaling (Swain et al 2005). Interestingly, in Xenopus, Frzb and Crescent can activate canonical Wnt signaling by promoting the diffusion of Wnt8 and Wnt11 (Mii and Taira 2009).…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Secreted and Transmembrane Wnt Inhibitors and Activators

Cruciat

Niehrs

2012

Cold Spring Harbor Perspectives in Biology

539

450

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The ankyrin repeat protein Diversin recruits Casein kinase Iε to the β-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling

Cited by 182 publications

References 55 publications

β-Catenin destruction complex: insights and questions from a structural perspective

β-Catenin destruction complex: insights and questions from a structural perspective

Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development

Secreted and Transmembrane Wnt Inhibitors and Activators

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