Using a new analysis tool, namely, multiscale window transform (MWT), and the MWT-based theory of canonical transfer, this study investigates the spatiotemporal variations of the nonlinear interactions among the mean flows, interannual variabilities, quasi-annual fluctuations, and eddies in the global ocean. It is found that the canonical kinetic energy (KE) transfers are highly inhomogeneous in space, maximized in the western boundary current (WBC), Southern Ocean, and equatorial regions. In contrast to the equatorial and WBC regions where the temporal KE cascades are mainly forward, the Southern Ocean is the very place where coherent large-scale patterns of inverse KE cascade take place. The canonical transfers are also found to be highly variable in time. Specifically, in the Kuroshio Extension, the transfer from the mean flow to the interannual variability is in pace with the external winds from the eastern North Pacific; in the subtropical gyre, the mean flow-to-eddy transfer is responsible for the variability of the eddy kinetic energies (EKE) at both interannual and seasonal scales; in the tropics, the downscale transfers to the eddies from the other three scales all contribute to the interannual modulation of the EKE, and these transfers tend to decrease (increase) during El Niño (La Niña) events. In the Southern Ocean, the high-frequency eddies are found to feed KE to the low-frequency variability through temporal inverse cascade processes, which have been strengthened due to the enhanced eddy activities in the recent decade. Also discussed here is the relation between the seasonal EKE variability and the eddy–quasi-annual fluctuation interaction.