The anodic oxidation of some tetracyclines

Chatten, L.G.; Fleischmann, M.; Pletcher, Derek

doi:10.1016/s0022-0728(79)80467-2

Cited by 17 publications

(7 citation statements)

References 4 publications

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“…Masawat and Slater 12 also observed best voltammetric responses and good resolution for both peaks at a gold electrode in acidic medium. Chatten et al 35 suggest the dimethylamino group or phenol as likely sites for the initial oxidation at a potential less than +1.0 V (vs. SCE). The amino groups are protonated in the two aqueous acetate buffers pH 4.0 and 5.6 used by those authors, leading them to conclude that the phenolic moiety of the molecule undergoes an one electron irreversible oxidation.…”

Section: Effect Of Ph On the Dpv Voltammogramsmentioning

confidence: 99%

“…The amino groups are protonated in the two aqueous acetate buffers pH 4.0 and 5.6 used by those authors, leading them to conclude that the phenolic moiety of the molecule undergoes an one electron irreversible oxidation. 35 On the other hand, Dang et al 36 observed only one TC oxidation peak around +0.58 V (vs. SCE) and attributed this peak to the phenolic substituent in position C-10 of TC. The mechanism of electrode process proposed by these authors was based on the oxidation of phenol group to benzoquinone, which is adsorbed at the acetylene black electrode surface.…”

Section: Effect Of Ph On the Dpv Voltammogramsmentioning

confidence: 99%

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Determination of tetracycline in environmental water samples at a graphite-polyurethane composite electrode

Calixto¹,

Cervini²,

Cavalheiro³

2012

J. Braz. Chem. Soc.

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O eletrodo compósito grafite-poliuretana foi avaliado na determinação de tetraciclina (TC) em amostras de água natural. Utilizando voltametria de pulso diferencial (DPV), uma resposta linear foi observada no intervalo de 4,00-40,0 µmol L-1 com limite de detecção de 2,80 µmol L-1 , sem necessidade de renovação da superfície entre medidas sucessivas. Durante determinação de tetraciclina em amostras de água, foram obtidas recuperações entre 92,6 e 100%. Os resultados para determinação de TC em amostras de água após a etapa de pré-concentração concordam com valor adicionado em um nível de confiança de 95% de acordo com o teste t-student. A bare graphite-polyurethane composite was evaluated in the tetracycline (TC) determination in natural water samples. Using differential pulse voltammetry (DPV), a linear response was observed in the range of 4.00-40.0 µmol L-1 with limit of detection of 2.80 µmol L-1 , without the need of surface renewing between successive runs. During the tetracycline determination in water samples, recoveries between 92.6 and 100% were found. The results for TC determination in water samples after a pre-concentration stage agreed with spiked value at a 95% confidence level according to student t-test.

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Section: Effect Of Ph On the Dpv Voltammogramsmentioning

confidence: 99%

Section: Effect Of Ph On the Dpv Voltammogramsmentioning

confidence: 99%

Determination of tetracycline in environmental water samples at a graphite-polyurethane composite electrode

Calixto¹,

Cervini²,

Cavalheiro³

2012

J. Braz. Chem. Soc.

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“…Following 20 and 30 trilayer application, slight oxidation peaks developed in the voltammograms at approximately 0.55 V, shown by the arrows in Figure A and B. These oxidation peaks are likely due to the oxidation of minocycline, which has been reported to occur at 0.5 V versus SCE . Though the minocycline released from this LBL paradigm has been shown to retain its neuroprotective effects, the effect of voltages applied across the coating was not considered.…”

Section: Resultsmentioning

confidence: 99%

Electrochemical Evaluation of Layer-by-Layer Drug Delivery Coating for Neural Interfaces

Olczak

McDermott

Otto

2019

ACS Appl. Bio Mater.

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Intracortical microelectrode arrays (MEAs) are valuable tools for neuroscience research, and their potential clinical use has been demonstrated. However, their inability to function reliably over chronic time points has limited their clinical translation. MEA failure is highly correlated with foreign body response (FBR), and therapeutics have been used to reduce FBR and improve device function, with drugs such as minocycline showing promising results in vivo. To avoid issues associated with systemic drug delivery, device coatings can be used to for therapeutic delivery. One method to locally deliver minocycline is a layer-by-layer (LBL) coating that consists of multiple trilayers of gelatin type A, minocycline, and dextran sulfate; however, the coating's impact on device function was previously unknown. This work characterized 10, 20, and 30 trilayer coatings and then evaluated their effect on device function. Cumulative minocycline release and coating thickness increased with the number of trilayers, agreeing with observations in previous studies. Atomic force microscopy images were used to calculate surface roughness of the coatings, which significantly increased from 10 to 20 trilayers and then remained relatively constant upon increasing to 30 trilayers. Scanning electron microscopy images confirmed that trilayers coated the MEAs. Electrochemical impedance spectroscopy (EIS) and charge carrying capacity (CCC) were used to evaluate the coating's effect on MEA electrochemical behavior over 3 weeks while the coated MEAs soaked in PBS. The 10 trilayer coatings slightly decreased CCC, while 20 and 30 trilayers initially increased CCC. CCC of all trilayers gradually increased as the MEAs soaked in PBS. All trilayers initially increased MEA impedance magnitude and reduced the phase angle at low frequencies. Impedance magnitude at 1 kHz and 15 kHz decreased toward their initial precoated values for all trilayers as the MEAs soaked in PBS. Overall, these results show that the LBL coatings did not significantly impact MEA function.

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“…Numerous studies using polarographic methods for the determination of tetracyclines have been reported in the literature [14,15]. The processes of oxidation of tetracycline and tetracycline derivatives have been analyzed by cyclic voltammetry on electrodes of Au or Pt, showing that the general oxidation mechanism follows an irreversible pathway on the electrode surface [16].…”

Section: Introductionmentioning

confidence: 99%

Transfer of tetracyclines across the H2O|1,2-dichloroethane interface: Analysis of degraded products in strong acid and alkaline solutions

Fernández

Dassie

2005

Journal of Electroanalytical Chemistry

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The anodic oxidation of some tetracyclines

Cited by 17 publications

References 4 publications

Determination of tetracycline in environmental water samples at a graphite-polyurethane composite electrode

Determination of tetracycline in environmental water samples at a graphite-polyurethane composite electrode

Electrochemical Evaluation of Layer-by-Layer Drug Delivery Coating for Neural Interfaces

Transfer of tetracyclines across the H2O|1,2-dichloroethane interface: Analysis of degraded products in strong acid and alkaline solutions

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