The antagonism of the analgesic effect of dipyrone by l-dopa and its relation to brain amine concentrations

Khayyal, Mohamed T.; Samaan, H. A.; Galal, E E

doi:10.1111/j.2042-7158.1978.tb13200.x

Cited by 6 publications

(2 citation statements)

References 8 publications

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“…Indeed, it is only in Brazil that we have a report that dipirone is the drug of choice for patients who suffer from chronic headache (6,7) . Except for a possible role in raising the brain levels of serotonine (8,9) , there are no controlled studies of the benefit of this drug in the management of migraine. We believe that doctors on Casualty duty in Santos are using IV dipirone out of previous experience, and not considering alternative treatments which do not have the possible side effects of IV dipirone, namely drowsiness, hypothermia and hypotension.…”

Section: Discussionmentioning

confidence: 99%

Management of primary headache in emergency services of Santos and surrounding towns

Fragoso¹,

Pl²,

Mb³

et al. 1998

Sao Paulo Med. J.

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OBJECTIVES: Primary headaches are often seen by Clinicians on duty at Emergency Services. We have investigated the treatment of such patients by 43 medical doctors who have been working at Emergency Services in the city of Santos and surrounding towns for many years. RESULTS: We confirmed the high prevalence of primary headaches in Emergency Services. There seem to be diagnosis difficulties concerning differentiating attacks of migraine and tension type headache. We also observed that IV dipirone was the most frequently prescribed treatment for patients with primary headaches in this study. There is no protocol in the literature which recommends IV dipirone for the treatment of migraine attacks or other primary headaches. CONCLUSION: It would be advisable to perform controlled double blind studies in order to verify the advantages of IV dipirone in the treatment of intense attacks primary headaches. We concluded that headache management recycling programs could be of interest for doctors who regularly work at Emergency Services.

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Section: Discussionmentioning

confidence: 99%

Management of primary headache in emergency services of Santos and surrounding towns

Fragoso¹,

Pl²,

Mb³

et al. 1998

Sao Paulo Med. J.

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“…66 Lastly, drugs like dipirone which elevate brain serotonin lose their analgesic effect when they follow a pretreatment with I-dopa, which interferes with the synthesis of this amine. 67 Although the monoamines do not cross the haemato-brain barrier, their levels in peripheral blood vary according to the circumstances affecting the central nervous system. Thus, for example, captivity induces depressive behaviour and raises the blood 5HT level in dogs.…”

Section: Discussionmentioning

confidence: 99%

Physiological, Clinical and Therapeutical Basis of a New Hypothesis for Headache

Lechín¹,

Dijs²

1980

Headache

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SYNOPSIS In the light of therapeutic, biochemical, physiological, pharmacological and clinical evidences, we postulate that the headache syndrome is due to an autonomic nervous system (ANS) imbalance, triggered by many aetiological factors. Consequently, this syndrome is most often observed in those subjects whose ANS balance is precarious, i.e. neurotics and psychotics. Two main types of headache patients could be differentiated: (1) those showing predominance of the serotonergic (5HT) over the catecholaminergic (CA) system (depressive patients) and (2) those showing predominance of CA over 5HT system (manic or hypomanic patients).

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Electrically Induced Tachyarrhythmia and the Effect of Propranolol on the Release of Cyclic AMP and Prostaglandin E by the Canine Left Ventricle

Eg¹,

Lehmann²,

Hj³

et al. 1982

Advances in Myocardiology

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The antagonism of the analgesic effect of dipyrone by l-dopa and its relation to brain amine concentrations

Cited by 6 publications

References 8 publications

Management of primary headache in emergency services of Santos and surrounding towns

Management of primary headache in emergency services of Santos and surrounding towns

Physiological, Clinical and Therapeutical Basis of a New Hypothesis for Headache

Electrically Induced Tachyarrhythmia and the Effect of Propranolol on the Release of Cyclic AMP and Prostaglandin E by the Canine Left Ventricle

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