The anterior olfactory nucleus revisited – An emerging role for neuropathological conditions?

Brunert, Daniela; Quintela, Renata Medinaceli; Rothermel, Markus

doi:10.1016/j.pneurobio.2023.102486

Cited by 11 publications

(2 citation statements)

References 228 publications

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“…It is unclear why we did not observe the widespread reward-related modula,on in tu_ed cells, even though some value-like ac,vity is present in the anterior olfactory nucleus 4 , a region known to have modulatory influence over tu_ed cells 17 . Since the anterior olfactory nucleus has mul,ple compartments 54 with each with dis,nct long-range connec,vity 55 , it will be crucial for future studies to resolve how these subregions contribute to associa,ng values with olfactory s,muli. Another poten,al source of reward-related signals are classical neuromodulatory regions.…”

Section: Discussionmentioning

confidence: 99%

Reward contingency modulates olfactory bulb output via pathway-dependent peri-somatic inhibition

Lindeman,

Fu,

Reinert

et al. 2023

Preprint

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Associating values to environmental cues is a critical aspect of learning from experiences, allowing animals to predict and maximise future rewards. Value-related signals in the brain were once considered a property of higher sensory regions, but its wide distribution across many brain regions is increasingly recognised. Here, we investigate the nature of reward-related signals at the earliest stage of olfactory processing, namely, in the olfactory bulb. In head-fixed mice performing Go/No-Go discrimination of closely related olfactory mixtures, rewarded odours evoke widespread inhibition in one class of output neurons, that is, in mitral cells but not tufted cells. The temporal characteristics of this reward-related inhibition suggest it is odour-driven, but it is also context-dependent since it is absent during pseudo-conditioning and pharmacological silencing of the piriform cortex. Further, the reward-related modulation is present in the somata but not in the apical dendritic tuft of mitral cells, suggesting an involvement of circuit component located deep in the olfactory bulb. Depth-resolved imaging from granule cell dendritic gemmules suggests that granule cells that target mitral cells receive a reward-related extrinsic drive. Our results support the notion that value-related modulation appears at the early stages of sensory processing and provide constraints on long-range and local circuit mechanisms.

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Section: Discussionmentioning

confidence: 99%

Reward contingency modulates olfactory bulb output via pathway-dependent peri-somatic inhibition

Lindeman,

Fu,

Reinert

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…It is unclear why we did not observe the widespread reward-related modulation in tufted cells, even though some value-like activity is present in the anterior olfactory nucleus [ 4 ], a region known to have modulatory influence over tufted cells [ 17 ]. Since the anterior olfactory nucleus has multiple compartments [ 67 ], each with distinct long-range connectivity [ 68 ], it will be crucial for future studies to resolve how these subregions contribute to associating values with olfactory stimuli.…”

Section: Discussionmentioning

confidence: 99%

Value-related learning in the olfactory bulb occurs through pathway-dependent perisomatic inhibition of mitral cells

Lindeman,

Fu,

Reinert

et al. 2024

PLoS Biol

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Associating values to environmental cues is a critical aspect of learning from experiences, allowing animals to predict and maximise future rewards. Value-related signals in the brain were once considered a property of higher sensory regions, but their wide distribution across many brain regions is increasingly recognised. Here, we investigate how reward-related signals begin to be incorporated, mechanistically, at the earliest stage of olfactory processing, namely, in the olfactory bulb. In head-fixed mice performing Go/No-Go discrimination of closely related olfactory mixtures, rewarded odours evoke widespread inhibition in one class of output neurons, that is, in mitral cells but not tufted cells. The temporal characteristics of this reward-related inhibition suggest it is odour-driven, but it is also context-dependent since it is absent during pseudo-conditioning and pharmacological silencing of the piriform cortex. Further, the reward-related modulation is present in the somata but not in the apical dendritic tuft of mitral cells, suggesting an involvement of circuit components located deep in the olfactory bulb. Depth-resolved imaging from granule cell dendritic gemmules suggests that granule cells that target mitral cells receive a reward-related extrinsic drive. Thus, our study supports the notion that value-related modulation of olfactory signals is a characteristic of olfactory processing in the primary olfactory area and narrows down the possible underlying mechanisms to deeper circuit components that contact mitral cells perisomatically.

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Pain experience reduces social avoidance to others in pain: a c-Fos-based functional connectivity network study in mice

Li,

Qin,

Zhong

et al. 2024

Cerebral Cortex

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Pain experience increases individuals’ perception and contagion of others’ pain, but whether pain experience affects individuals’ affiliative or antagonistic responses to others’ pain is largely unknown. Additionally, the neural mechanisms underlying how pain experience modulates individuals’ responses to others’ pain remain unclear. In this study, we explored the effects of pain experience on individuals’ responses to others’ pain and the underlying neural mechanisms. By comparing locomotion, social, exploration, stereotyped, and anxiety-like behaviors of mice without any pain experience (naïve observers) and mice with a similar pain experience (experienced observers) when they observed the pain-free demonstrator with intraperitoneal injection of normal saline and the painful demonstrator with intraperitoneal injection of acetic acid, we found that pain experience of the observers led to decreased social avoidance to the painful demonstrator. Through whole-brain c-Fos quantification, we discovered that pain experience altered neuronal activity and enhanced functional connectivity in the mouse brain. The analysis of complex network and graph theory exhibited that functional connectivity networks and activated hub regions were altered by pain experience. Together, these findings reveal that neuronal activity and functional connectivity networks are involved in the modulation of individuals’ responses to others’ pain by pain experience.

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The anterior olfactory nucleus revisited – An emerging role for neuropathological conditions?

Cited by 11 publications

References 228 publications

Reward contingency modulates olfactory bulb output via pathway-dependent peri-somatic inhibition

Reward contingency modulates olfactory bulb output via pathway-dependent peri-somatic inhibition

Value-related learning in the olfactory bulb occurs through pathway-dependent perisomatic inhibition of mitral cells

Pain experience reduces social avoidance to others in pain: a c-Fos-based functional connectivity network study in mice

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