The Anterior Third Ventricle Region is a Receptor Site for Composition Rather than Volume of Body Fluids

Lichardus, B; Ponec, J; Okolicány, J; Gabauer, I; Styk, J; Bakos, P; Oliver, Charles; Michajlovskij, N

doi:10.1007/978-1-4684-5799-5_13

Cited by 1 publication

(2 citation statements)

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“…Dilution of CSF sodium prevented completely natriuresis following the ECFV expansion. This is thus another indication of that the brain may be involved in the control of renal regulation of ECFV by monitoring sodium concentration in CSF ( 24 ).…”

Section: Involvement Of Peripheral and Central Nervous System In The mentioning

confidence: 99%

“…It was further proposed that increased renal Na excretion in response to hypernatremia is another cerebrally mediated osmoregulatory response. However, the AV3V region does not seem to be critical for the mechanism of natriuresis induced by ECFV expansion with isotonic saline ( 24 , 26 , 27 ).…”

Section: Involvement Of Peripheral and Central Nervous System In The mentioning

confidence: 99%

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Early Stages of the Natriuretic Hormone Story

Lichardus

2014

Front. Endocrinol.

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The paper reviews the early stages of the research on natriuretic hormone. The described experimental work was designed and accomplished in several internationally recognized laboratories where the author was invited to extend his projects. The cross-circulation experiments in animals with acutely increased extracellular fluid volume documented, that in the mechanism of natriuresis – besides a series of the physical natriuretic factors – there is still room for an active humoral natriuretic substance. This substance inhibited the sodium transporting enzyme, Na,K-ATPase, in the frog skin. Analogous inhibition of the renal Na,K-ATPase may be partly responsible for the increased sodium excretion. It was further shown that the extent of natriuresis is positively modulated by the concentration of sodium in the cerebrospinal fluid detected in the anterior-third ventricle region (AV3V) in the brain.

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Section: Involvement Of Peripheral and Central Nervous System In The mentioning

confidence: 99%

Section: Involvement Of Peripheral and Central Nervous System In The mentioning

confidence: 99%