The anthocyanins in black currants regulate postprandial hyperglycaemia primarily by inhibiting α-glucosidase while other phenolics modulate salivary α-amylase, glucose uptake and sugar transporters

Barik, Sisir Kumar; Russell, Wendy; Moar, Kim-Marie; Cruickshank, Morven; Scobbie, Lorraine; Duncan, Gary; Hoggard, Nigel

doi:10.1016/j.jnutbio.2019.108325

Cited by 84 publications

(60 citation statements)

References 50 publications

(59 reference statements)

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“…Such a difference is even more evident when considering the HPLC-ESI-QTOF-MS profile at a signal-to-noise ratio < 10:1 (Table S2; values at t 0 ). The same has been reported for black and green currants [43] and strawberries [26] when comparing the polyphenolic profile of these berries before and after in vitro digestion, it was observed that not only the quantity of parental polyphenols but also their chemical nature differed (also observed in Figure 4). Many biological and analytical factors are involved in this phenomenon, including the pH-instability (neutral > acidic) of polyphenols, particularly anthocyanins [8,20], the REDOX status of parent/metabolites (m/z ± 0.3), HPLC-ESI-QTOF-MS limit of detection (10:1 signal-to-noise) and their reversible interaction with digestive enzymes and mucin [5,10,44].…”

Section: Hplc-esi-qtof-mssupporting

confidence: 81%

First-Pass Metabolism of Polyphenols from Selected Berries: A High-Throughput Bioanalytical Approach

et al. 2020

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Small berries are rich in polyphenols whose first-pass metabolism may alter their ultimate physiological effects. The antioxidant capacity and polyphenol profile of three freeze-dried berries (blackberry, raspberry, Red Globe grape) were measured and their apparent permeability (Papp) and first-pass biotransformation were tracked with an ex vivo bioanalytical system [everted gut sac (rat) + three detection methods: spectrophotometry, HPLC-ESI-QTOF-MS, differential pulse voltammetry (DPV)]. Total polyphenol (ratio 0.07-0.14-1.0) and molecular diversity (anthocyanins > flavan-3-ols), antioxidant capacity (DPPH, FRAP), anodic current maxima and Papp (efflux> uptake) were in the following order: blackberry > raspberry > Red Globe grape. Epicatechin, pelargonidin & cyanin (all), callistephin (raspberry/blackberry), catechin (grape), cyanidin glycosides (blackberry) and their derived metabolites [quinic acid, epicatechin, cyanidin/malvidin glucosides, and chlorogenic/caffeic acids] were fruit-specific and concentration-dependent. Time-trend DPV kinetic data revealed concurrent epithelial permeability & biotransformation processes. Regular permeability and high-biotransformation of berry polyphenols suggest fruit-specific health effects apparently at the intestinal level.

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Section: Hplc-esi-qtof-mssupporting

confidence: 81%

First-Pass Metabolism of Polyphenols from Selected Berries: A High-Throughput Bioanalytical Approach

et al. 2020

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“…Finding phenolic compounds after intestinal digestion showed their availability to be metabolized and absorbed after reaching the colon. Apart from showing antioxidant capacity, (poly) phenols may act as digestive enzyme inhibitors, affecting the activity of α-glucosidase, α-amylase, and lipase, which may contribute to the control of diabetes type II and obesity, delivering other health benefits attributed to the ingestion of berries as part of the diet [ 55 , 56 ].…”

Section: Resultsmentioning

confidence: 99%

Characterization of Andean Blueberry in Bioactive Compounds, Evaluation of Biological Properties, and In Vitro Bioaccessibility

Baenas

Ruales

Moreno

et al. 2020

Foods

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The aim of this study was to evaluate Andean blueberries (Vaccinium floribundum Kunth) from Ecuador as a potential functional ingredient for the food and pharmaceutical industries. The analysis of bioactive compounds by HPLC–DAD–MSn determined a high content of (poly)phenols, mainly anthocyanins, and the presence of the carotenoid lutein. Regarding its biological properties, Andean blueberry did not show toxicity by the zebrafish embryogenesis test, showing also a lack of the antinutrients lectins. Moreover, the results of in vitro and in vivo antioxidant capacity evaluation suggested its possibility to be used as natural antioxidant. This fruit also exhibited antimicrobial activity toward Staphylococcus aureus and Escherichia coli in low doses. Finally, in vitro gastrointestinal (GI) digestion showed a partial bioaccessibility of (poly) phenols (~50% at the final step), showing high antioxidant capacity in the different GI phases. These results revealed Andean blueberry as an interesting candidate for being used as a functional ingredient and the development of further in vivo and clinical assays.

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“…The antioxidant activity of cyanidin is 4.4 times higher than that of ascorbic acid. Among edible plants, berries of red, blue or purple color, such as wild cherries, are one of the most important sources of anthocyanins in the diet [ 5 , 47 , 48 , 49 , 50 ]. Anthocyanins are mainly present in the outer layers of subcutaneous tissue.…”

Section: Phytocompounds Content In P Padus Andmentioning

confidence: 99%

Phytopharmacological Possibilities of Bird Cherry Prunus padus L. and Prunus serotina L. Species and Their Bioactive Phytochemicals

2020

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Wild cherry is a plant observed in the form of trees or shrubs. This species comprises about twenty kinds of plants and the most popular are two, Prunus padus L. and Prunus serotina L., whose properties and content of phytochemical compounds are subject to studies. Wild cherry contains many active compounds, including tocopherols, vitamins, polyphenols and terpenes, which can have beneficial effects on health. On the other hand, wild cherry contains cyanogenic glycosides. Nevertheless, current research results indicate pro-health properties associated with both P. serotina and P. padus. The aim of this study was to collect and present the current state of knowledge about wild cherry and to review available in vitro and in vivo studies concerning its antioxidant, anti-inflammatory, antibacterial and antidiabetic activity. Moreover, the current work presents and characterizes phytochemical content in the leaves, bark and fruits of P. padus and P. serotina and compiles data that indicate their health-promoting and functional properties and possibilities of using them to improve health. We find that the anatomical parts of P. padus and P. serotina can be a valuable raw material used in the food, pharmaceutical and cosmetic industries as a source of bioactive compounds with multi-directional action.

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The anthocyanins in black currants regulate postprandial hyperglycaemia primarily by inhibiting α-glucosidase while other phenolics modulate salivary α-amylase, glucose uptake and sugar transporters

Abstract: et al., The anthocyanins in black currants regulate postprandial hyperglycaemia primarily by inhibiting α-glucosidase while other phenolics modulate salivary α-amylase, glucose uptake and sugar transporters,

Cited by 84 publications

References 50 publications

First-Pass Metabolism of Polyphenols from Selected Berries: A High-Throughput Bioanalytical Approach

First-Pass Metabolism of Polyphenols from Selected Berries: A High-Throughput Bioanalytical Approach

Characterization of Andean Blueberry in Bioactive Compounds, Evaluation of Biological Properties, and In Vitro Bioaccessibility

Phytopharmacological Possibilities of Bird Cherry Prunus padus L. and Prunus serotina L. Species and Their Bioactive Phytochemicals

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