The anti-aging mechanism of ginsenosides with medicine and food homology

Tian, Tiantian; Ko, Chung-Nga; Luo, Wenya; Li, Dan; Yang, Chao

doi:10.1039/d3fo02580b

Cited by 15 publications

(5 citation statements)

References 136 publications

(163 reference statements)

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“…22 The primary pharmacologically active compounds extracted from ginseng have diverse bioactive functions encompassing anti-carcinogenic, anti-aging, anti-inflammatory and antioxidant properties. 23–26 Among these compounds, Ginsenoside-Rb2 (Rb2), the most abundant saponin identified in ginseng, has shown potential anti-osteoporosis effects according to a previous study. It has been reported that Rb2 inhibited osteoporosis induced by a ketogenic diet in mice.…”

Section: Introductionmentioning

confidence: 99%

Ginsenoside Rb2 exhibits therapeutic value for male osteoporosis in orchiectomy mice by suppressing osteoclastogenesis and modulating NF-κB/MAPK signaling pathways

Ma,

Li,

Mai

et al. 2024

Food Funct.

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Section: Introductionmentioning

confidence: 99%

Ginsenoside Rb2 exhibits therapeutic value for male osteoporosis in orchiectomy mice by suppressing osteoclastogenesis and modulating NF-κB/MAPK signaling pathways

Ma,

Li,

Mai

et al. 2024

Food Funct.

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“…Aging is mainly characterized by a progressive dysfunction of metabolism and various physiological roles. PDS and PTS are important antiaging drugs that could promote the metabolism and proliferation of stem cells, protect the skin, brain, heart, and nerves, enhance mitochondrial function and telomerase activity, and maintain the intestinal flora [ 46 ]. Xu et al reported that Rb1 and Rg1 reduced ROS production, increased CAT activity, elevated the mtDNA content and ATP level, and attenuated the MMP depolarization of primary mouse astrocytes injury induced by oxygen-glucose deprivation/reoxygenation (OGD/R).…”

Section: Pharmacological Effects and Mechanisms Of Pds And Ptsmentioning

confidence: 99%

Structural Characters and Pharmacological Activity of Protopanaxadiol‐Type Saponins and Protopanaxatriol‐Type Saponins from Ginseng

Zhang,

Gao,

Yang

et al. 2024

Advances in Pharmacological and Pharmaceutical Sciences

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Ginseng has a long history of drug application in China, which can treat various diseases and achieve significant efficacy. Ginsenosides have always been deemed important ingredients for pharmacological activities. Based on the structural characteristics of steroidal saponins, ginsenosides are mainly divided into protopanaxadiol‐type saponins (PDS, mainly including Rb1, Rb2, Rd, Rc, Rh2, CK, and PPD) and protopanaxatriol‐type saponins (PTS, mainly including Re, R1, Rg1, Rh1, Rf, and PPT). The structure differences between PDS and PTS result in the differences of pharmacological activities. This paper provides an overview of PDS and PTS, mainly focusing on their chemical profile, pharmacokinetics, hydrolytic metabolism, and pharmacological activities including antioxidant, antifatigue, antiaging, immunodulation, antitumor, cardiovascular protection, neuroprotection, and antidiabetes. It is intended to contribute to an in‐depth study of the relationship between PDS and PTS.

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“…TA-65, a compound containing cycloastragenol isolated from A. membranaceus roots, has been shown to increase telomerase activity in embryonic fibroblasts, inhibit DNA damage, and enhance immune function [ 22 , 23 ]. Ginseng is a valuable traditional Chinese medicine that contains ginsenosides, which are among the most important active ingredients for its anti-aging function [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Rosa roxburghii Fruit Extracts Upregulate Telomerase Activity and Ameliorate Cell Replicative Senescence

Huang,

Peng,

et al. 2024

Foods

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Anti-aging functional foods benefit the elderly. Telomeres are chromosomal ends that maintain genome stability extended by telomerase catalytic subunit TERT. Due to the end-replication problem, telomeres shorten after each cell cycle without telomerase in most human cells, and eventually the cell enters the senescence stage. Natural products can attenuate the aging process by increasing telomerase activity, such as TA-65. However, TA-65 is expensive. Other Chinese natural products may achieve comparable effects. Here, we found that Rosa roxburghii fruit extracts effectively increase TERT expression and telomerase activity in cultured human mesenchymal stem cells. Both R. roxburghii fruit extracts obtained by freeze-drying and spray-drying increased the activity of telomerase. R. roxburghii fruit extracts were able to reduce reactive oxygen species levels, enhance superoxide dismutase activity, and reduce DNA damage caused by oxidative stress or radiation. R. roxburghii fruit extracts promoted cell proliferation, improved senescent cell morphology, delayed replicative cellular senescence, attenuated cell cycle suppressors, and alleviated the senescence-associated secretory phenotype. Transcriptome and metabolic profiling revealed that R. roxburghii fruit extracts promote DNA replication and telomere maintenance pathways and decrease triglyceride levels. Overall, we provide a theoretical basis for the application of R. roxburghii fruit as an anti-aging product.

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The anti-aging mechanism of ginsenosides with medicine and food homology

Abstract: With the acceleration of global aging and the rise in living standard, the achieving of healthy aging is becoming an imperative issue globally. Ginseng, a medicinal plant that has a...

Cited by 15 publications

References 136 publications

Ginsenoside Rb2 exhibits therapeutic value for male osteoporosis in orchiectomy mice by suppressing osteoclastogenesis and modulating NF-κB/MAPK signaling pathways

Ginsenoside Rb2 exhibits therapeutic value for male osteoporosis in orchiectomy mice by suppressing osteoclastogenesis and modulating NF-κB/MAPK signaling pathways

Structural Characters and Pharmacological Activity of Protopanaxadiol‐Type Saponins and Protopanaxatriol‐Type Saponins from Ginseng

Rosa roxburghii Fruit Extracts Upregulate Telomerase Activity and Ameliorate Cell Replicative Senescence

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