The anti-angiogenic herbal composition Ob-X fromMorus alba,Melissa officinalis, andArtemisia capillarisregulates obesity in genetically obese ob/ob mice

Yoon, Michung; Kim, Minyoung

doi:10.3109/13880209.2010.539617

Cited by 30 publications

(14 citation statements)

References 23 publications

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“…Similar to previous results showing that anti-angiogenic herbal composition Ob-X reduces adipose tissue mass and body weight gain in obese mice [55,101], body weights and adipose tissue mass were much less in ginseng-treated mice compared with untreated mice (Fig. 5A and B) [61].…”

Section: Korean Red Ginseng Prevents Obesity By Inhibiting Angiogenesissupporting

confidence: 90%

The Role of Angiogenesis in Obesity

Yoon

2014

Journal of Life Science

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Angiogenesis, the formation of new capillary blood vessels, is a tightly regulated process. Under normal physiological conditions, angiogenesis only takes place during embryonic development, wound healing, and female menstruation. Dysregulation of angiogenesis is associated with many diseases, such as cancer, rheumatoid arthritis, psoriasis, and proliferative retinopathy. The growth and expansion of adipose tissue require the formation of new blood vessels. Adipose tissue is probably the most highly vascularized tissue in the body, as each adipocyte is surrounded by capillaries, and the angiogenic vessels supply nutrients and oxygen to adipocytes. Accumulating evidence shows that capillary endothelial cells communicate with adipocytes via paracrine signaling pathways, extracellular components, and direct cell-cell interactions. Activated adipocytes produce multiple angiogenic factors, including VEGF, FGF-2, leptin, and HGF, which either alone or cooperatively stimulate the expansion and metabolism of adipose tissue by increasing adipose tissue vasculature. Recently, it was demonstrated that antiangiogenic herbal Ob-X extracts and Korean red ginseng extracts reduce adipose tissue mass and suppress obesity by inhibiting angiogenesis in obese mice. Thus, angiogenesis inhibitors provide a promising therapeutic approach for controlling human obesity and related disorders.

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Section: Korean Red Ginseng Prevents Obesity By Inhibiting Angiogenesissupporting

confidence: 90%

The Role of Angiogenesis in Obesity

Yoon

2014

Journal of Life Science

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“…Two other plant extract, in particular, appear very promising with a view of clinical use: a Melissa leaf ethyl acetate dried extract, ALS-L1203, provided with angiogenesis and MMP inhibitory activities, showed to be active in a Phase II clinical trial in reducing visceral fat, without adverse effects. Phase III studies are ongoing (NCT01872182) (Hamni Pharmaceuticals Co Ltd Seoul, Korea), [154] and Ob-X [155]. In ob/ob mice, Ob-X inhibit angiogenesis and decreases BW gain; moreover, it inhibits hepatic lipid accumulation and significantly decreased circulating glucose levels compared with controls.…”

Section: Plant Extractsmentioning

confidence: 99%

New Perspectives on the Development of Antiobesity Drugs

Costantino

Barlocco

2015

Future Med. Chem.

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After many years of research, obesity is still a disease with an unmet medical need. Very few compounds have been approved, acting mainly on neuromediators; researches, in recent years, pointed toward compounds potentially safer than first-generation antiobesity drugs, able to interact with one or more (multitarget therapy) receptors for substances produced by the gut, adipose tissue and other targets outside CNS. Other holistic approaches, such as those involving gut microbiota and plant extracts, appeared recently in the literature, and undoubtedly will contribute to the discovery of a valuable therapy for this disease. This review deals with the positive results and the pitfalls obtained following these approaches, with a view on their clinical trial studies.

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“…Previous evaluations regarding the possible angiogenic implications of lemon balm extracts were performed only in vitro on HUVEC endothelial cell lines and in vivo on mouse models. Aqueous extracts were found to decrease VEGFinduced angiogenesis (vascular endothelial growth factor) in a dose related manner [46], while hydroethanolic extracts reduced VEGF-A, increased TSR (thrombospondin type 1 repeat) mRNA expression in mice, and inhibited the capillary-like formation in HUVEC cell line [20]. e antitumor effect of MO ethanolic extracts on prostate, colon, and breast cancer seems to be in part due to the downregulation of VEGF-A and hTERT (telomerase reverse transcriptase) as regulators of carcinogenesis [19].…”

Section: Antiangiogenic Effects In Ovo Using the Cam Assaymentioning

confidence: 99%

Lemon Balm Extracts Prevent Breast Cancer Progression In Vitro and In Ovo on Chorioallantoic Membrane Assay

Ghiulai

Avram

Stoian

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Breast cancer is the most frequently diagnosed malignant pathology, representing the primary cause of cancer death in women. Natural products are an appealing strategy to limit the progression of the disease. Targeting angiogenesis in breast cancer may positively impact on poor prognosis of breast cancer. As source of natural compounds, we investigated the leaves of Melissa officinalis L. (MO), known as lemon balm, an aromatic plant that spontaneously grows in the South and Western areas of Romania, being traditionally recommended as anxiolytic, antispasmodic, or as digestive remedy. Our aim was to investigate the phytochemical profiling and the antiangiogenic and chemopreventive bioactivity of MO from Banat region, on breast cancer. Two ethanolic extracts of MO (MOE96 and MOE70) and one methanolic extract (MOM80) were subjected to polyphenol and triterpene profiling by HPLC-MS, and the antioxidant capacity was evaluated. The antiangiogenic potential was investigated using the chorioallantoic membrane assay (CAM). The MTT(3-(4,5-dimethylthiazol-2-yl)-2-5-diphenyltetrazolium bromide) assay was used to investigate the cytotoxic effects on MCF-7 and MDA-MB-231breast cancer cells, as well as on MCF-10A normal breast epithelial cells, while apoptosis was performed by DAPI staining. Rosmarinic acid (RA) and ursolic acid (UA) were revealed as dominant phytocompounds. The highest concentration in phytochemicals were found in MOM80; MOE96 was more concentrated in UA, while MOE70 extracted more RA. MOE96 inhibited cancer progression and angiogenesis in the in ovo CAM model using MDA-MB-231 cells, inhibiting breast cancer progression and angiogenesis for the MDA-MB-231 breast cancer cell line; no secondary tumoral areas were registered, indicative for a preventive effect against breast tumor cell invasiveness. The highest cell inhibitory activity was also exhibited by MOE96, in particular against the estrogen receptor positive MCF7 breast cancer cell line, with no cytotoxic effect on healthy cells. The estrogen receptor positive MCF7 cell line proved to be more sensitive to the extract antiproliferative activity than the triple negative MDA-MB-231 breast cancer cell line. Nevertheless, the chemopreventive potential of MOE96 extract is phenotype-dependent and is rather related to the apoptosis and antiangiogenic effects suggesting a multitargeted mechanism of action due to its multiple compound composition next to a concentration ratio of RA : UA in favor of UA.

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The anti-angiogenic herbal composition Ob-X fromMorus alba,Melissa officinalis, andArtemisia capillarisregulates obesity in genetically obese ob/ob mice

Cited by 30 publications

References 23 publications

The Role of Angiogenesis in Obesity

The Role of Angiogenesis in Obesity

New Perspectives on the Development of Antiobesity Drugs

Lemon Balm Extracts Prevent Breast Cancer Progression In Vitro and In Ovo on Chorioallantoic Membrane Assay

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