The anti-angiogenic potential of (±) gossypol in comparison to suramin

Ulus, Gönül; Koparal, Ayşe Tansu; Baysal, Kemal; Yetik‐Anacak, Gunay; Yavaşoğlu, Nefise Ülkü Karabay

doi:10.1007/s10616-018-0247-z

Cited by 9 publications

(8 citation statements)

References 28 publications

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“…In recent years, strategies that prevent the feeding or metastasis of tumor cells have become more popular than directly intervening with the tumor in the cancerous tissue [23,24]. The chick chorioallantoic membrane (CAM) assay is a method that quantitatively and visually confirms the anti-or proangiogenic effectiveness of the tested sample [25].…”

Section: Resultsmentioning

confidence: 99%

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Anticancer and antiangiogenesis activities of novel synthesized 2-substitutedbenzimidazoles molecules

Güner¹,

Polatlı²,

Akkan³

et al. 2019

Turk J Chem

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In this study, novel 2-substituted benzimidazoles molecules having triazole, thiadiazole, and oxadiazole rings were synthesized and were evaluated by anticancer, antioxidant/oxidant status, genotoxicity, and antiangiogenesis assays.Anticancer activity of the compounds was determined by MTT (0.5, 5, and 50 µ g/mL) and lactate dehydrogenase (LDH) release assays against human prostate and breast cancer cells. Oxidative status of cells was elicited by total oxidative stress and total antioxidant capacity methods. Chick chorioallantoic membrane assay was used to evaluate the antiangiogenic activity. Genotoxicity was evaluated by the sister chromatid exchange (SCE) and micronucleus (MN) tests in lymphocyte cultured human blood. Our results showed that some of the compounds synthesized had significant antiproliferative activity against both cancer cell lines (between 4.54 ± 0.35 and 20.17 ± 3.15 µ g/mL), with higher inhibition of the breast cancer, and caused inhibition of LDH release with a linear correlation to MTT results. Moreover, the 5 µ g/mL dose of these molecules led to an increase in antioxidant levels. Compounds had antiangiogenic effectiveness in a dose-dependent manner. Additionally, all of the compounds did not affect SCE and MN levels compared to controls.In conclusion, these newly synthesized molecules can be a resource of new anticancer agents with their nongenotoxic, antiproliferative, and antiangiogenic properties.

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Section: Resultsmentioning

confidence: 99%

“…Antiangiogenic effects of samples were determined on fertile Leghorn chicken eggs weighing 50-60 g by using a CAM method modified by Ulus et al [25]. Fertilized eggs were placed into an incubator with a conveyor rotation system at 37 ± 1 • C and 80 ± 2% humidity for 6 days.…”

Section: Antiangiogenic Activitymentioning

confidence: 99%

Anticancer and antiangiogenesis activities of novel synthesized 2-substitutedbenzimidazoles molecules

Güner¹,

Polatlı²,

Akkan³

et al. 2019

Turk J Chem

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“…Numerous studies have reported that angiogenesis is a hallmark of the malignant transformation of tumors [12, 13]. Several antitumor drugs are aimed at inhibiting neovascularization to reduce the oxygen and nutrient supply of tumors, which prevents the growth of tumors [14–16]. ANGPTL2 has been shown to contribute to the proliferation and invasion of gastric cancer cells, and it has been reported to be a potential biomarker for colorectal cancer [17].…”

Section: Discussionmentioning

confidence: 99%

Dihydroartemisinin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cell by Upregulating Tumor Necrosis Factor via JNK/NF-κB Pathways

Cheng

Deng

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Background. Dihydroartemisinin (DHA) is a predominant compound in Artemisia annua L., and it has been shown to inhibit tumorigenesis. Methods. In this study, the antitumor potential of DHA was investigated in the MHCC97-L hepatocellular carcinoma cell line. Cells were treated at various concentrations of DHA, and then the cell cycle, viability, and DNA synthesis were measured to evaluate cell proliferation. Furthermore, the expression of genes and proteins related to proliferation and apoptosis was measured to determine the effects of DHA. Finally, the mechanism was investigated using RNA-sequencing to identify differentially expressed genes and signaling pathways, and JNK/NF-κB pathways were evaluated with Western blotting. Results. Cells were treated with a concentration range of DHA from 1 to 100 μM, and cell proliferation was suppressed in a dose-dependent manner. In addition, the genes and proteins involved in typical cellular functions of MHCC97-L cells were significantly inhibited. DHA treatment downregulated the angiogenic gene ANGPTL2 and the cell proliferation genes CCND1, E2F1, PCNA, and BCL2. DHA treatment significantly upregulated the apoptotic genes CASP3, CASP8, CASP9, and TNF. Global gene expression profiles identified 2064 differentially expressed genes (DEGs). Among them, 744 were upregulated and 1320 were downregulated. Furthermore, MAPK, NF-kappa B, and TNF pathways were enriched based on the DEGs, and the consensus DEG was identified as TNF using a Venn diagram of those pathways. DHA promoted phosphorylation of JNK, inhibited nuclear p65, and then significantly induced TNF-α synthesis. Conclusion. DHA inhibited cell proliferation and induced apoptosis in human hepatocellular carcinoma cells by upregulating TNF expression via JNK/NF-κB pathways.

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“…Natural products derived from plants have been used as herbal medicines for a long time. Because of the harmful side effects of chemical agents, plants used in medicine have been very popular recently (Ulus et al, 2018). Lichens are symbiotic organisms composed of fungi (mycobiont) and green algae and/or cyanobacteria (photobiont; Emsen et al, 2016;Varol, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Lichen secondary metabolites have important roles in metal balance and protection against pollution in the organism (Molnár & Farkas, 2009). Angiogenesis is the process of the growing of new vessels from pre-existing vessels (Ulus et al, 2018;Figure 2). Angiogenesis which is a complex mechanism is a response to the increasement in requirements of oxygen and nutrient in tissue mass (Tong et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Antiangiogenic properties of lichen secondary metabolites

Ulus

2021

Phytotherapy Research

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Lichens are symbiotic organisms which are composed fungi and algae and/or cyanobacteria. They produce a variety of characteristic secondary metabolites. Such substances have various biological properties including antimicrobial, antiviral, and antitumor activities. Angiogenesis, the growth of new vessels from pre-existing vessels, contributes to numerous diseases including cancer, arthritis, atherosclerosis, infectious, and immune disorders. Antiangiogenic therapy is a promising approach for the treatment of such diseases by inhibiting the new vessel formation. Technological advances have led to the development of various antiangiogenic agents and have made possible antiangiogenic therapy in many diseases associated with angiogenesis. Some lichens and their metabolites are used in the drug industry, but many have not yet been tested for their antiangiogenic effects. The cytotoxic and angiogenic capacities of lichen-derived small molecules have been demonstrated in vivo and in vitro experiments. Therefore, some of them may be used as antiangiogenic agents in the future. The secondary compounds of lichen whose antiangiogenic effect has been studied in the literature are usnic acid, barbatolic acid, vulpinic acid, olivetoric acid, emodin, secalonic acid D, and parietin. In this article, we review the antiangiogenic effects and cellular targets of these lichen-derived metabolites.

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The anti-angiogenic potential of (±) gossypol in comparison to suramin

Cited by 9 publications

References 28 publications

Anticancer and antiangiogenesis activities of novel synthesized 2-substitutedbenzimidazoles molecules

Anticancer and antiangiogenesis activities of novel synthesized 2-substitutedbenzimidazoles molecules

Dihydroartemisinin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cell by Upregulating Tumor Necrosis Factor via JNK/NF-κB Pathways

Antiangiogenic properties of lichen secondary metabolites

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