The anti-apoptotic effect of fucoxanthin on carbon tetrachloride-induced hepatotoxicity

Kaneko, Mieko; Nagamine, Takahiko; Nakazato, Kyoumi; Mori, Masataka

doi:10.2131/jts.38.115

Cited by 16 publications

(11 citation statements)

References 47 publications

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“…These are responsible for regulation of different biological responses, including cell growth, apoptosis, ECM production and collagen gel contraction [12]. Experimentally, carbon tetrachloride (CCl 4 ) toxicity is considered as the best animal model of xenobiotic-induced acute or chronic liver damage through overproduction of ROS [13,14]. The hepatitis induced by long-term exposure of CCl 4 leads to hepatic fibrosis due to hepatocyte necrosis and overproduction of fibrogenic cytokines such as TGF-β acting on fibroblasts and activated HSCs [15].…”

Section: Introductionmentioning

confidence: 99%

Natural polyphenols target the TGF-β/caspase-3 signaling pathway in CCl4-induced liver fibrosis in rats

Abu-Baih¹,

Bayoumi

Ibrahim

et al. 2019

Journal of advanced Biomedical and Pharmaceutical Sciences

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Background/Aims: Liver fibrosis presents a worldwide problem. There is an increasing interest in the studying of natural compounds with free radicals scavenging capacity to protect against liver fibrosis. This study investigated the actions of resveratrol and curcumin as two natural polyphenols against CCl 4 -induced liver fibrosis. Materials and Methods: Animals were divided into four groups: Normal control group; CCl 4 only group; Res group (resveratrol + CCl 4 ); Cur group (curcumin + CCl 4 ). Serum ALT and AST were evaluated. Assessment of liver MDA, GSH and catalase was performed. Caspase-3 expression was evaluated by western blotting. Levels of TGF-β1 and TGF-β2 mRNA were determined using qRT-PCR. In addition, liver histopathological sections were examined. Results: We found that serum ALT and AST were elevated by CCl 4 , however, they were significantly reduced by resveratrol and curcumin. Furthermore, CCl 4 induced oxidative stress, stimulated fibrosis and apoptosis. Resveratrol and curcumin significantly attenuated the state of oxidative stress, fibrosis and apoptosis. Conclusion: We conclude that resveratrol and curcumin are natural polyphenols that can protect against liver fibrosis not only via antioxidant, but also via anti-fibrotic and anti-apoptotic potentials.

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Section: Introductionmentioning

confidence: 99%

Natural polyphenols target the TGF-β/caspase-3 signaling pathway in CCl4-induced liver fibrosis in rats

Abu-Baih¹,

Bayoumi

Ibrahim

et al. 2019

Journal of advanced Biomedical and Pharmaceutical Sciences

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“…Carbon tetrachloride (CCl 4 ) is a well-known hepatotoxin that is widely used to induce acute or chronic toxic liver injury in a large range of laboratory animals [1, 2]. Chronic hepatotoxicity induces oxidative damage, necrosis, and inflammation in the liver [3].…”

Section: Introductionmentioning

confidence: 99%

Turmeric extract and its active compound, curcumin, protect against chronic CCl4-induced liver damage by enhancing antioxidation

Lee

Kim²,

Lee

et al. 2016

BMC Complement Altern Med

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BackgroundCurcumin, a major active component of turmeric, has previously been reported to alleviate liver damage. Here, we investigated the mechanism by which turmeric and curcumin protect the liver against carbon tetrachloride (CCl4)-induced injury in rats. We hypothesized that turmeric extract and curcumin protect the liver from CCl4-induced liver injury by reducing oxidative stress, inhibiting lipid peroxidation, and increasing glutathione peroxidase activation.MethodsChronic hepatic stress was induced by a single intraperitoneal injection of CCl4 (0.1 ml/kg body weight) into rats. Turmeric extracts and curcumin were administered once a day for 4 weeks at three dose levels (100, 200, and 300 mg/kg/day). We performed ALT and AST also measured of total lipid, triglyceride, cholesterol levels, and lipid peroxidation.ResultWe found that turmeric extract and curcumin significantly protect against liver injury by decreasing the activities of serum aspartate aminotransferase and alanine aminotransferase and by improving the hepatic glutathione content, leading to a reduced level of lipid peroxidase.ConclusionsOur data suggest that turmeric extract and curcumin protect the liver from chronic CCl4-induced injury in rats by suppressing hepatic oxidative stress. Therefore, turmeric extract and curcumin are potential therapeutic antioxidant agents for the treatment of hepatic disease.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-016-1307-6) contains supplementary material, which is available to authorized users.

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“…Epidemiological data has suggested that the regular consumption of seaweeds can reduce the risk of developing diseases associated with oxidative stress. As a dietary antioxidant, fucoxanthin improves the antioxidant capacity of blood serum levels (Kang et al 2014), and is capable of quenching reactive oxygen species under hypoxic physiological conditions, unlike the majority of food-derived antioxidants (Kaneko et al 2013). Reactive oxygen species are known to cause cellular damage, which is implicated in the pathogenesis of disorders such as cardiovascular disease, cancer, metabolic syndrome, and type II diabetes.…”

Section: Introductionmentioning

confidence: 99%

Optimisation of fucoxanthin extraction from Irish seaweeds by response surface methodology

Shannon¹,

Abu‐Ghannam²

2016

J Appl Phycol

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Fucoxanthin is a xanthophyll pigment which occurs in marine brown algae (Phaeophyceae). The anti-diabetic, anti-obesity, anti-cancer, and antioxidant properties of fucoxanthin have been widely reported. Macroalgae, particularly brown seaweeds, grow prolifically around Irish coasts, representing a valuable resource of nutraceuticals such as fucoxanthin for functional food applications. The aim of this study was to maximise the solvent extraction yield from three anatomically discrete regions of the seaweed thallus: blade, stipe, and holdfast. Response surface methodology was applied to determine optimum parameters for extraction of fucoxanthin from the seaweed, Fucus vesiculosus, as a model species. A central composite design was applied with four extraction variables: time (30-70 min), temperature (30-70°C), solvent pH (5.0-9.0), and percentage acetone (30-70 %). Fucoxanthin content of extracts was quantified by highperformance liquid chromatography. Percentage acetone was found to have the most significant (P = 0.0002) effect on fucoxanthin yield, followed by pH (P = 0.028) and temperature (P = 0.049). Multiple response optimisation determined that fucoxanthin yield from F. vesiculosus may be maximised by incubating at 30.0°C for 36.5 min, pH 5.7, with 62.2 % acetone. Optimised responses were applied to a further nine brown seaweeds; Alaria esculenta, Ascophyllum nodosum, Fucus serratus, Himanthalia elongata, Laminaria digitata, Laminaria hyperborea, Pelvetia canaliculata, Saccharina latissima, and Saccorhiza polyschides. In all species, the blades contained significantly more fucoxanthin than stipes, while holdfasts contained the least. Alaria esculenta blade had the greatest yield (0.870 mg g −1 dry mass), followed by ).

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The anti-apoptotic effect of fucoxanthin on carbon tetrachloride-induced hepatotoxicity

Cited by 16 publications

References 47 publications

Natural polyphenols target the TGF-β/caspase-3 signaling pathway in CCl4-induced liver fibrosis in rats

Natural polyphenols target the TGF-β/caspase-3 signaling pathway in CCl4-induced liver fibrosis in rats

Turmeric extract and its active compound, curcumin, protect against chronic CCl4-induced liver damage by enhancing antioxidation

Optimisation of fucoxanthin extraction from Irish seaweeds by response surface methodology

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