The anti-bacterial activity of titanium-copper sintered alloy against &lt;i&gt;Porphyromonas gingivalis&lt;/i&gt; &lt;i&gt;in vitro &lt;/i&gt;

Bai, Bing; Zhang, Erlin; Liu, Junchao; Zhu, Jingtao

doi:10.4012/dmj.2016-001

Cited by 32 publications

(13 citation statements)

References 45 publications

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“…In addition, as long as the Cu content in the Ti-Cu sintered alloy exceeds 5 wt%, a continuous and stable antibacterial effect can be obtained (Liu et al, 2014). It was effective against not only S. aureus and E. coli but also the common anaerobic bacterium Porphyromonas gingivalis (Bai et al, 2016). The excellent antibacterial effects and good biocompatibility of the Ti-10Cu sintered alloy have been verified in a rabbit muscle infection model .…”

Section: Applications Of Common Antibacterial Metals and Alloys In Iai Antibacterial Ti Alloymentioning

confidence: 88%

Recent Advances in Research on Antibacterial Metals and Alloys as Implant Materials

Jiao

Zhang

et al. 2021

Front. Cell. Infect. Microbiol.

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Implants are widely used in orthopedic surgery and are gaining attention of late. However, their use is restricted by implant-associated infections (IAI), which represent one of the most serious and dangerous complications of implant surgeries. Various strategies have been developed to prevent and treat IAI, among which the closest to clinical translation is designing metal materials with antibacterial functions by alloying methods based on existing materials, including titanium, cobalt, tantalum, and biodegradable metals. This review first discusses the complex interaction between bacteria, host cells, and materials in IAI and the mechanisms underlying the antibacterial effects of biomedical metals and alloys. Then, their applications for the prevention and treatment of IAI are highlighted. Finally, new insights into their clinical translation are provided. This review also provides suggestions for further development of antibacterial metals and alloys.

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Section: Applications Of Common Antibacterial Metals and Alloys In Iai Antibacterial Ti Alloymentioning

confidence: 88%

Recent Advances in Research on Antibacterial Metals and Alloys as Implant Materials

Jiao

Zhang

et al. 2021

Front. Cell. Infect. Microbiol.

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“…The present investigation focused on alloying up to 10 wt% of Cu into commercially pure titanium (a well-known implant material), where Cu has shown antibacterial potential in previous studies [17,20,38,39]. Its purpose was to determine the resultant microstructural and antibacterial characteristics of the materials, as a function of Cu addition and ageing heat treatments.…”

Section: Discussionmentioning

confidence: 99%

Development of Antibacterial Ti-Cux Alloys for Dental Applications: Effects of Ageing for Alloys with Up to 10 wt% Cu

et al. 2019

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Peri-implantitis, a disease caused by bacteria, affects dental implants in patients. It is widely treated with antibiotics, however, with growing antibiotic resistance new strategies are required. Titanium-copper alloys are prospective antibacterial biomaterials, with the potential to be a remedy against peri-implantitis and antibiotic resistance. The aim of this study was to investigate Ti-Cux alloys, exploring how Cu content (up to 10 wt%) and ageing affect the material properties. Electron microscopy, X-ray diffraction, hardness testing, bacteriological culture, and electrochemical testing were employed to characterize the materials. It was found that alloys with above 3 wt% Cu had two phases and ageing increased the volume fraction of Ti2Cu. An un-aged alloy of 5 wt% Cu showed what could be Ti3Cu, in addition to the α-Ti phase. The hardness gradually increased with increased Cu additions, while ageing only affected the alloy with 10 wt% Cu (due to changes in microstructure). Ageing resulted in faster passivation of the alloys. After two hours the aged 10 wt% Cu alloy was the only material with an antibacterial effect, while after six hours, bacteria killing occurred in all alloys with above 5 wt% Cu. In conclusion, it was possible to tune the material and antibacterial properties of Ti-Cux alloys by changing the Cu concentration and ageing, which makes further optimization towards an antibacterial material promising.

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“…Recently, as a local drug delivery system, antibacterial nanomaterials to modify the tooth surface have been experimentally tested. Metallic nanoparticles showed significant antibacterial effects against oral bacterial cells through antibacterial metallic ion release [4,5,6]. Therapy comprising nanoparticle coating of tooth surfaces is likely beneficial for prevention and improvement of periodontal disease.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial coating of tooth surface with ion-releasing pre-reacted glass-ionomer (S-PRG) nanofillers

Mayumi

Miyaji

Miyata

et al. 2021

Heliyon

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Surface pre-reacted glass-ionomer (S-PRG) fillers release antibacterial borate and fluoride ions. We fabricated nanoscale S-PRG fillers (S-PRG nanofillers) for antibacterial coating of tooth surfaces and assessed the antibacterial effects of this coating in vitro. In addition, we creating a canine model of periodontitis to evaluate the effectiveness of S-PRG nanofiller application on tooth roots and improvement of periodontal parameters.Methods: Human dentin blocks were coated with S-PRG nanofiller (average particle size: 0.48 μm) and then characterized by scanning electron microscopy (SEM), energy dispersive X-ray spectrometer (EDX), and ionreleasing test. Antibacterial effects of dentin blocks coated with S-PRG nanofiller were examined using bacterial strains, Streptococcus mutans and Actinomyces naeslundii. Next, we created an experimental model of periodontitis in furcation of premolars of beagle dogs. Then, S-PRG nanofiller coating was applied onto exposed tooth root surfaces. Periodontal parameters, gingival index (GI), bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment level (CAL), were measured from baseline until 4 weeks. In addition, bone healing was radiographically and histologically examined. Results: SEM and EDX revealed that S-PRG nanofillers uniformly covered the dentin surface after coating. Dentin blocks coated with S-PRG nanofiller showed ion-releasing property, bacterial growth inhibition, and sterilization effects. In the experimental periodontitis model, S-PRG nanofiller coating significantly reduced clinical inflammatory parameters, such as GI (P < 0.01) and BOP (P < 0.05), compared to uncoated samples. In addition, PPD and CAL significantly decreased by S-PRG nanofiller coating (2 weeks: P < 0.05; 3 and 4 weeks: P < 0.01), suggesting the improvement of periodontitis. Micro-CT and histology revealed that bone healing of furcation defects was enhanced by S-PRG nanofiller coating. Conclusion: S-PRG nanofiller coating provides antibacterial effects to tooth surfaces and improves clinical parameters of periodontitis.

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The anti-bacterial activity of titanium-copper sintered alloy against <i>Porphyromonas gingivalis</i> <i>in vitro </i>

Cited by 32 publications

References 45 publications

Recent Advances in Research on Antibacterial Metals and Alloys as Implant Materials

Recent Advances in Research on Antibacterial Metals and Alloys as Implant Materials

Development of Antibacterial Ti-Cux Alloys for Dental Applications: Effects of Ageing for Alloys with Up to 10 wt% Cu

Antibacterial coating of tooth surface with ion-releasing pre-reacted glass-ionomer (S-PRG) nanofillers

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