The anti‐cancer effect of chitosan/resveratrol polymeric nanocomplex against triple‐negative breast cancer; an in vitro assessment

Bozorgi, Azam; Haghighi, Zahra Ojaghi; Khazaei, Mohammad; Bozorgi, Maryam; Khazaei, Mozafar

doi:10.1049/nbt2.12108

Cited by 11 publications

(4 citation statements)

References 51 publications

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“…A group of researchers examined the effectiveness of resveratrol-entrapped chitosan nanoparticles (RSV-Cs NPs) in triggering apoptosis in MDA-MB 231 cells [ 70 ]. The ionic gelation technique was used to formulate dummy NPs (Cs NPs) and RSV-Cs NPs (RSV-Cs NPs), which were then further characterized.…”

Section: Resveratrol-entrapped Nanosystemsmentioning

confidence: 99%

Resveratrol-Laden Nano-Systems in the Cancer Environment: Views and Reviews

Sarfraz,

Arafat,

Zaidi

et al. 2023

Cancers

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The genesis of cancer is a precisely organized process in which normal cells undergo genetic alterations that cause the cells to multiply abnormally, colonize, and metastasize to other organs such as the liver, lungs, colon, and brain. Potential drugs that could modify these carcinogenic pathways are the ones that will be used in clinical trials as anti-cancer drugs. Resveratrol (RES) is a polyphenolic natural antitoxin that has been utilized for the treatment of several diseases, owing to its ability to scavenge free radicals, control the expression and activity of antioxidant enzymes, and have effects on inflammation, cancer, aging, diabetes, and cardioprotection. Although RES has a variety of pharmacological uses and shows promising applications in natural medicine, its unpredictable pharmacokinetics compromise its therapeutic efficacy and prevent its use in clinical settings. RES has been encapsulated into various nanocarriers, such as liposomes, polymeric nanoparticles, lipidic nanocarriers, and inorganic nanoparticles, to address these issues. These nanocarriers can modulate drug release, increase bioavailability, and reach therapeutically relevant plasma concentrations. Studies on resveratrol-rich nano-formulations in various cancer types are compiled in the current article. Studies relating to enhanced drug stability, increased therapeutic potential in terms of pharmacokinetics and pharmacodynamics, and reduced toxicity to cells and tissues are the main topics of this research. To keep the readers informed about the current state of resveratrol nano-formulations from an industrial perspective, some recent and significant patent literature has also been provided. Here, the prospects for nano-formulations are briefly discussed, along with machine learning and pharmacometrics methods for resolving resveratrol’s pharmacokinetic concerns.

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Section: Resveratrol-entrapped Nanosystemsmentioning

confidence: 99%

Resveratrol-Laden Nano-Systems in the Cancer Environment: Views and Reviews

Sarfraz,

Arafat,

Zaidi

et al. 2023

Cancers

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“…Many attempts have been made to overcome these hurdles using nanoparticles. The encapsulation of resveratrol in nanoparticles increases its absorption, bioavailability, and sustained release [ 38 , 39 , 40 , 41 , 42 , 43 , 44 ]. Cutting-edge nanoparticle technology has revolutionized engineers’ and scientists’ approaches to various fields of study.…”

Section: Introductionmentioning

confidence: 99%

Recent Developments in Nanoparticle Formulations for Resveratrol Encapsulation as an Anticancer Agent

Ali,

Benfante,

Di Raimondo

et al. 2024

Pharmaceuticals

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Resveratrol is a polyphenolic compound that has gained considerable attention in the past decade due to its multifaceted therapeutic potential, including anti-inflammatory and anticancer properties. However, its anticancer efficacy is impeded by low water solubility, dose-limiting toxicity, low bioavailability, and rapid hepatic metabolism. To overcome these hurdles, various nanoparticles such as organic and inorganic nanoparticles, liposomes, polymeric nanoparticles, dendrimers, solid lipid nanoparticles, gold nanoparticles, zinc oxide nanoparticles, zeolitic imidazolate frameworks, carbon nanotubes, bioactive glass nanoparticles, and mesoporous nanoparticles were employed to deliver resveratrol, enhancing its water solubility, bioavailability, and efficacy against various types of cancer. Resveratrol-loaded nanoparticle or resveratrol-conjugated nanoparticle administration exhibits excellent anticancer potency compared to free resveratrol. This review highlights the latest developments in nanoparticle-based delivery systems for resveratrol, focusing on the potential to overcome limitations associated with the compound’s bioavailability and therapeutic effectiveness.

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“…The best solution to protect them from early absorption and enhance their bioavailability in the aqueous milieu is to encapsulate them in the form of nano-emulsions. 9,11 Nanogels are three-dimensional (3D) cross-linked polymeric structures with nano-sized distribution and high swelling potential. Nanogels have recently gained much attention in drug delivery because of biocompatibility, high loading capacity for various biomolecules, protecting cargo molecules from degradation, and allowing controlled drug release at the target site.…”

Section: Introductionmentioning

confidence: 99%

Fabrication, characterization, and in vivo implantation of eugenol-loaded nanogels and PCL/Cs electrospun nanofibers for wound healing applications

Noori,

Osanloo,

Moradi

et al. 2023

Journal of Bioactive and Compatible Polymers

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Developing wound dressings with a high potential to cover damaged skin tissue and facilitate cell adhesion and migration at the injury site is crucial in skin tissue engineering to accelerate wound healing. Electrospun nanofibers from natural/synthetic polymers are amongst the favorable wound dressings with appropriate physicochemical and biological properties. As well, nanoformulations of phenolic phytochemical “eugenol” have been shown to fasten wound healing via various anti-inflammatory and anti-oxidant effects. Herein, we developed a bi-component wound dressing of PCL/Cs electrospun nanofibers and eugenol nanogel to investigate its effects on tissue healing in vivo. PCL/Cs nanofibers were fabricated using an electrospinning method at the 15:1 ratio, and eugenol-loaded nanogels were synthesized by adding carboxymethylcellulose as the gelling agent, and their physicochemical characteristics were assessed. Scaffolds were implanted in a full-thickness excision wound model in Wistar rats, followed up for 21 days. The results showed that electrospun nanofibers had an average diameter of 228 nm with uniform and smooth morphology aligned randomly. Eugenol-loaded nanogel showed an average size distribution of 126 nm. Eugenol-loaded nanogel and nanogel + nanofiber groups significantly reduced wound surface area over 21 days. Histological evaluations showed that Eugenol-loaded nanogel and nanogel + nanofiber groups developed the full-thickness epidermis with the complete epithelium and stratum corneum, angiogenesis, and low macrophage infiltration in which predominantly mature collagen fibers were poorly and well organized, respectively. The combination of eugenol-loaded nanogel + PCL/Cs nanofiber accelerated wound healing by reducing inflammation, and edema along with enhancing angiogenesis, collagen synthesis, and re-epithelialization.

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The anti‐cancer effect of chitosan/resveratrol polymeric nanocomplex against triple‐negative breast cancer; an in vitro assessment

Cited by 11 publications

References 51 publications

Resveratrol-Laden Nano-Systems in the Cancer Environment: Views and Reviews

Resveratrol-Laden Nano-Systems in the Cancer Environment: Views and Reviews

Recent Developments in Nanoparticle Formulations for Resveratrol Encapsulation as an Anticancer Agent

Fabrication, characterization, and in vivo implantation of eugenol-loaded nanogels and PCL/Cs electrospun nanofibers for wound healing applications

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