The anti-cancerous activity of adaptogenic herb Astragalus membranaceus

Aliya, Sheik; Kim, Kwanwoo; Raju, Ganji Seeta Rama; Lee, Hoomin; Kim, Suheon; Kim, Eun-Su; Shin, Jin Yong; Oh, Sejong; Huh, Yun Suk

doi:10.1016/j.phymed.2021.153698

Cited by 66 publications

(25 citation statements)

References 84 publications

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“…Astragali Radix is the root of A. membranaceus Bunge, which has been widely used in immune response and supports the body to detoxify. Moreover, A. membranaceus is considered to be safe and nontoxic, and the dosage of LD50 is approximately 40 g/kg [27]. APS is the main efective constituent of Astragali Radix, which has been widely used in recent years [28].…”

Section: Discussionmentioning

confidence: 99%

Astragalus Polysaccharides Alleviate Lung Adenocarcinoma Bone Metastases by Inhibiting the CaSR/PTHrP Signaling Pathway

2023

Journal of Food Biochemistry

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Bone metastasis is one of the common complications of lung cancer and can lead to bone-related adverse events, such as pathological fractures, spinal cord defects, and nerve compression syndrome. As an effective medicinal component of Astragalus membranaceus, Astragalus polysaccharide (APS) has antitumor activity and alleviates osteoporosis to a certain extent. In this study, we explored the possible role and mechanism underlying APS inhibition of lung adenocarcinoma bone metastases by constructing a mouse model of lung adenocarcinoma bone metastases. First, we constructed osteoclast (OC) and osteoblast (OB) culture systems in vitro to confirm that APS affected the differentiation and function of OCs and OBs. Then, using the mouse bone metastasis model, microCT, and bone histopathology, we confirmed that APS inhibited osteolytic metastasis and tumor cell proliferation in mice, and the effect was mainly realized by inhibiting the CaSR/PTHrP signal pathway. The results showed that APS had a protective effect on lung adenocarcinoma bone metastases.

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Section: Discussionmentioning

confidence: 99%

Astragalus Polysaccharides Alleviate Lung Adenocarcinoma Bone Metastases by Inhibiting the CaSR/PTHrP Signaling Pathway

2023

Journal of Food Biochemistry

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“…Astragalus membranaceus (AM) is a commonly used herbal medicine that contains a large number of bioactive components and it has a wide range of pharmacological effects [7]. Studies have shown that the bio-active components of AM can not only modulate the immune system, but also reduce the side effects caused by radiotherapy and chemotherapy, thereby enhancing the antitumor efficacy of cancer patients [8]. Therefore, AM has significant research implications in the treatment of gastrointestinal cancers [9].…”

Section: Surgicalmentioning

confidence: 99%

Identification of key genes and active components of Astragalus membranaceus in the treatment of colorectal cancer based on bioinformatics analysis

Xiang¹,

Ke²,

Miao³

et al. 2023

Trop. J. Pharm Res

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Purpose: To investigate the bio-active components and key targets of Astragalus membranaceus (AM) in the treatment of colorectal cancer (CRC) through bioinformatics analysis.Methods: An AM action network was constructed after taking intersection of the target genes in AM and CRC-related genes. After that, Protein-Protein Interaction analysis, Gene Ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were performed on the intersected genes. Then, the differential genes in GSE70772 and GSE113513 datasets were screened separately and intersected with genes from the PPI analysis to obtain the key targets.Results: After intersection with potential targets of AM and CRC-related genes, 105 genes were screened by PPI analysis. Then, 20 genes were identified as potential target genes of AM in GSE70772 and GSE113513 datasets. These genes were intersected with the 105 genes. Finally, a key gene called MET was identified as the key target of action of AM in the treatment of CRC, and methylnissolin (MOL000380) was the active component of AM.Conclusion: MET a potential key target gene of AM, whose active component is methylnissolin, in the treatment of CRC. Thus, the findings of this study may provide a scientific basis for the further development of AM for the treatment of CRC.

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“…Astragalus membranaceus (Fisch.) Bunge, a perennial species of Leguminosae family, is widely distributed in Eastern Asia, Europe, and North America (Sheik et al 2021). A. membranaceus root is a famous herb in traditional Chinese medicine (TCM) and also recorded in pharmacopoeias of Japan, Korea, the United States, and Europe, which is highly appreciated for the multiple pharmacological functions such as immunomodulatory, antitumor, antiviral, antifatigue, anti-in ammatory, antioxidant, cardioprotective, antihyperglycemic, neuroprotective, and hepatoprotective activities (Fu et Iso avonoids and astragalosides are well-known as the primary bioactive ingredients in A. membranaceus root (Fu et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Blue LED light promoting the growth, accumulation of high-value isoflavonoids and astragalosides, antioxidant response, and biosynthesis gene expression in Astragalus membranaceus (Fisch.) Bunge hairy root cultures

Gai

Feng

Jiao

et al. 2023

Preprint

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The root of Astragalus membranaceus (Fisch.) Bunge is one of the most frequently used herbs in traditional Chinese medicine (TCM) formulae for fighting COVID-19 infections, due to the presence of isoflavonoids and astragalosides associated with antiviral and immune-enhancing activities. For the first time, the exposure of A. membranaceus hairy root cultures (AMHRCs) to different colors of LED lights i.e., red, green, blue, red/green/blue (1/1/1, RGB), and white, was conducted to promote the root growth and accumulation of isoflavonoids and astragalosides. LED light treatment regardless of colors was found beneficial for root growth, which might be a result of the formation of more root hairs upon light stimulation. Blue LED light was found most effective for enhancing phytochemical accumulation. Results showed that the productivity of root biomass in blue-light grown AMHRCs with an initial inoculum size of 0.6% for 55 days was 1.40-fold higher than that in dark (control), and yields of high-value isoflavonoids and astragalosides including calycosin, formononetin, astragaloside IV, and astragaloside I increased by 3.17-fold, 2.66-fold, 1.78-fold, and 1.52-fold relative to control, respectively. Moreover, the photooxidative stress together with transcriptional activation of biosynthesis genes might contribute to the enhanced accumulation of isoflavonoids and astragalosides in blue-light grown AMHRCs. Overall, this work offered a feasible approach for obtaining higher yields of root biomass and medicinally important compounds in AMHRCs via the simple supplementation of blue LED light, which made blue-light grown AMHRCs industrially attractive as plant factory in controlled growing systems.

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The anti-cancerous activity of adaptogenic herb Astragalus membranaceus

Cited by 66 publications

References 84 publications

Astragalus Polysaccharides Alleviate Lung Adenocarcinoma Bone Metastases by Inhibiting the CaSR/PTHrP Signaling Pathway

Astragalus Polysaccharides Alleviate Lung Adenocarcinoma Bone Metastases by Inhibiting the CaSR/PTHrP Signaling Pathway

Identification of key genes and active components of Astragalus membranaceus in the treatment of colorectal cancer based on bioinformatics analysis

Blue LED light promoting the growth, accumulation of high-value isoflavonoids and astragalosides, antioxidant response, and biosynthesis gene expression in Astragalus membranaceus (Fisch.) Bunge hairy root cultures

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