The Anti-Depression-Like Effects of Zhengtian Capsule via Induction of Neurogenesis and the Neurotrophic Signaling Pathway

Yang, Liang; Wang, Yong; Li, Nuomin; Xu, Bing; Duan, Juanhui; Yuan, Chunxu; Yuan, Qinfen; Yang, Qifan; Qing, Hong; Dai, Zhi; Quan, Zhenzhen

doi:10.3389/fphar.2020.01338

Cited by 5 publications

(8 citation statements)

References 54 publications

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“…such as Prunus spinos showed antioxidant and anti-inflammatory properties [453,454]. Zhengtian Capsule is a Chinese patent medicine that consists of a mixture of 15 herbs including Prunus persica [455]. It has been shown that this drug can alleviate symptoms similar to oxidative stress depression, increase proliferation of neural stem cells and neurons, promote levels of BDNF, phosphorylated ERK1/2 and CREB and suppress expression of NF-κB.…”

Section: Prunus Sppmentioning

confidence: 99%

Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis

Walczak-Nowicka

Herbet

2021

IJMS

119

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Acetylcholinesterase (AChE) plays an important role in the pathogenesis of neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative stress and aggregation of pathological proteins. There is a search for new compounds that can prevent the occurrence of neurodegenerative diseases and slow down their course. The aim of this review is to present the role of AChE in the pathomechanism of neurodegenerative diseases. In addition, this review aims to reveal the benefits of using AChE inhibitors to treat these diseases. The selected new AChE inhibitors were also assessed in terms of their potential use in the described disease entities. Designing and searching for new drugs targeting AChE may in the future allow the discovery of therapies that will be effective in the treatment of neurodegenerative diseases.

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Section: Prunus Sppmentioning

confidence: 99%

Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis

Walczak-Nowicka

Herbet

2021

IJMS

119

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“…agrimoniin inhibited cell growth, promoted apoptosis inhibited tumor growth (Hnit et al., 2021; Kim et al., 2020). Agrimonolide also decreased the activation of JAK‐STAT and NFκB in LPS‐stimulated macrophages (Yang et al., 2020). Therefore, the present study investigated the inhibitory effect of natural product compound extract from APLME on metastasis.…”

Section: Discussionmentioning

confidence: 99%

The inhibitory effect of Agrimonia Pilosa methanolic extract on matrix metalloproteinases in HT1080 cells

Eom

Kim

2021

J Food Biochem

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The risk of cancer increases with aging due to the accumulation of cellular deterioration that can spread to other organs through the blood and lymphatic vessels. Therefore, the inhibition of metastasis is a major concern for the treatment of cancer. Several synthetic drugs have been developed for the treatment of various cancers. However, these drugs are effective; nonspecific action and side effects on the normal human cells limit their wide acceptance, thus demanding some potential alternative. Hence, the present study emphasizes investigating the effect of a methanolic extract of Agrimonia Pilosa (APLME) on matrix metalloproteinases (MMPs) in human fibroblast sarcoma cells. The action of APLME on MMP‐2 and MMP‐9 was investigated using gelatin zymography. APLME suppressed the activities of MMP‐2 and MMP‐9 in PMA (phorbol myristate acetate)‐treated HT1080 cells. In addition, western blot analysis and immunofluorescence were performed to investigate the effect of APLME on the expression of the proteins that are the major proteins involved in cell invasion and metastasis. APLME treatment inhibited the expression of MMP‐2 and MMP‐9 in addition to the activations of JNK, ERK, and AKT‐1. Furthermore, APLME was observed to suppress cell invasion related to metastasis using cell invasion assay. Therefore, the above findings indicate that APLME inhibits the expression activity of MMP‐2 and MMP‐9 via inactivation of ERK and JNK in addition to AKT‐1, leading to inhibiting cell invasion. Therefore, these results indicate that APLME may be used as a candidate substance for inhibiting cell invasion. Practical applications Cancer increases the cell invasion to other organs through the blood and lymphatic vessels. Cancer cells deplete the nutrients and create new blood vessels that infiltrate and metastasize to other tissues. Therefore, this present study examined the effect of Agrimonia Pilosa on cell invasion. It was found that Agrimonia Pilosa methanolic extract inhibited the invasion of cancer cells through the inactivation of ERK and JNK. In addition, APLME reduced the activation and protein expression of MMP‐2 and MMP‐9 in addition to AKT‐1. Thus, APLME can be utilized as a potential alternative therapeutic agent for inhibiting metastasis.

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“…It is reported to cause reversible fetal or neonatal bradycardia [79][80][81][82][83][84][85][86][87][88][89].…”

Section: Prophylaxis In Pregnant Patientsmentioning

confidence: 99%

“…Feverfew ( Tanacetum parthenium ) has shown better results than a placebo in a few studies when given thrice daily in a patient with mild migraine at a dose of 6.25 mg [ 84 , 85 ]. Zhengtian capsules comprising 15 different traditional Chinese herbal medications showed efficacy comparable to flunarizine [ 86 , 87 ].…”

Section: Reviewmentioning

confidence: 99%

Revisiting Migraine: The Evolving Pathophysiology and the Expanding Management Armamentarium

Gawde¹,

Shah²,

Patel³

et al. 2023

Cureus

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Migraine affects about one billion people worldwide yearly and is one of the most common neurologic illnesses, with a high prevalence and morbidity, particularly among young adults and females. Migraine is associated with many comorbidities, including stress, sleep difficulties, and suicidal ideation. Migraine, despite its widespread occurrence, is underdiagnosed and undertreated. Because of the complicated and primarily unknown mechanisms of migraine formation, several social and biological risk factors, such as hormone imbalances, genetic and epigenetic impacts, and cardiovascular, neurological, and autoimmune illnesses, have been proposed. Through the mid-20th century diversion of the now-defunct vascular theory, the pathophysiology of migraine has developed from a historical study of the "humours" to a distinct entity as a neurological disorder. The range of therapeutic targets has broadened significantly, increasing the number of specialized clinical trials. Understanding the biology of migraine through careful research has resulted in the identification of major therapeutic classes: (i) triptans, serotonin 5-HT1B/1D receptor agonists, (ii) gepants, calcitonin gene-related peptide (CGRP) receptor antagonists, (iii) ditans, 5-HT1F receptor agonists, (iv) CGRP monoclonal antibodies, and (v) glurants, mGlu5 modulators, with further targets being explored. This review provides a comprehensive overview of the most recent literature on epidemiology and risk factors and exposes knowledge gaps.

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The Anti-Depression-Like Effects of Zhengtian Capsule via Induction of Neurogenesis and the Neurotrophic Signaling Pathway

Cited by 5 publications

References 54 publications

Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis

Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis

The inhibitory effect of Agrimonia Pilosa methanolic extract on matrix metalloproteinases in HT1080 cells

Revisiting Migraine: The Evolving Pathophysiology and the Expanding Management Armamentarium

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