The Anti-Depressive Effects of Hesperidin and the Relative Mechanisms Based on the NLRP3 Inflammatory Signaling Pathway

Xie, Lulu; Gu, Zhimin; Liu, Haizhao; Jia, Beitian; Wang, Yiyang; Cao, Min; Song, Ruiwen; Zhang, Zhaiyi; Bian, Yuhong

doi:10.3389/fphar.2020.01251

Cited by 51 publications

(22 citation statements)

References 48 publications

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“…Due to long-term exposure stress, high incidence rate, and severe economic burdens, depression has attracted global attention in recent years ( Beurel et al, 2020 ). Chronic stress can lead to low-grade inflammatory reaction, cell-mediated immune activation, and so on, and then lead to abnormal nerve conduction and brain functional network disorder, which are closely related to the occurrence of depression ( Franklin et al, 2018 ; Xie et al, 2020 ; Xie et al, 2021 ). At present, although many studies focus on the molecular imaging mechanism and drug treatment of depression, there are still no specific targeted drugs and compound preparations for depression.…”

Section: Discussionmentioning

confidence: 99%

“…The levels of IL-1β, IL-6, TNF-α, and CRP in peripheral blood of MDD patients were significantly increased (Haapakoski et al, 2015;Liu et al, 2017;Felger et al, 2020), and the levels of inflammatory factors in cerebrospinal fluid were abnormal (Haapakoski et al, 2015). At the same time, the expression of inflammatory factors in different tissues of depression animal model also increased (Pan et al, 2014;Zhang et al, 2015;Xie et al, 2020). Moreover, depression is closely related to inflammation damage-associated molecular patterns (DAMPs) Xie et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Xiaoyaosan Exerts Antidepressant Effect by Downregulating RAGE Expression in Cingulate Gyrus of Depressive-Like Mice

et al. 2021

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Xiaoyaosan (XYS), as a classic Chinese medicine compound, has been proven to have antidepressant effect in many studies, but its mechanism has not been clarified. In our previous studies, we found that chronic stress can induce depressive-like behavior and lead to emotion-related cingulate gyrus (Cg) dysfunction, as well as the decrease of neurotrophic factors and the increase of inflammatory-related proteins. Therefore, we speculated that XYS may play an antidepressant role by regulating the inflammation-related receptor of advanced glycation protein end product (RAGE) to affect the functional connectivity (FC) signal of the Cg and improve the depressive-like behavior. In order to verify this hypothesis, we analyzed the FC and RAGE expression in the Cg of depressive-like mice induced by chronic unpredictable mild stress (CUMS) and verified it with RAGE knockout mice. At the same time, we detected the effect of XYS on the depressive-like behavior, expression of RAGE, and the FC of the Cg of mice. The results showed that the FC of the Cg of depressive-like mice induced by CUMS was weakened, and the expression of RAGE was upregulated. The antidepressant effect of XYS is similar to that of fluoxetine hydrochloride, which can significantly reduce the depressive-like behavior of mice and inhibit the expression of the RAGE protein and mRNA in the Cg, and increase the FC of the Cg in mice. In conclusion, XYS may play an antidepressant role by downregulating the expression of RAGE in the Cg of depressive-like mice induced by CUMS, thereby affecting the functional signal and improving the depressive-like behavior.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Xiaoyaosan Exerts Antidepressant Effect by Downregulating RAGE Expression in Cingulate Gyrus of Depressive-Like Mice

et al. 2021

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“…We and others have confirmed that HDN attenuates inflammatory responses in I/R injury ( 9 , 17 ). In a chronic unpredictable mild stress (CUMS)-induced rat model, Xie et al ( 37 ) found that HDN treatment significantly relieved depressive-like behaviors in CUMS rats by decreasing the expression levels of IL-6 and TNF-α in the prefrontal cortex and microglia. In addition, they found that the relative mechanisms were based on the NLR family pyrin domain containing 3 inflammatory signaling pathway ( 37 ).…”

Section: Discussionmentioning

confidence: 99%

“…In a chronic unpredictable mild stress (CUMS)-induced rat model, Xie et al ( 37 ) found that HDN treatment significantly relieved depressive-like behaviors in CUMS rats by decreasing the expression levels of IL-6 and TNF-α in the prefrontal cortex and microglia. In addition, they found that the relative mechanisms were based on the NLR family pyrin domain containing 3 inflammatory signaling pathway ( 37 ). Heo et al ( 38 ) revealed that HDN treatment in rats with spinal cord injury reduced neuropathological changes (includinghemorrhage, inflammatory cell infiltration, and tissue loss) and levels of proinflammatory cytokines, such as TNF-α.…”

Section: Discussionmentioning

confidence: 99%

Potential protective effect of hesperidin on hypoxia/reoxygenation‑induced hepatocyte injury

Zhu

Pan

et al. 2021

Exp Ther Med

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Hesperidin (HDN) has been reported to have hydrogen radical-and hydrogen peroxide-removal activities and to serve an antioxidant role in biological systems. However, whether HDN protects hepatocytes (HCs) against hypoxia/reoxygenation (H/R)-induced injury remains unknown. The present study aimed to explore the role of HDN in H/R-induced injury. HCs were isolated and cultured under H/R conditions with or without HDN treatment. HC damage was markedly induced under H/R, as indicated by cell viability, supernatant lactate dehydrogenase levels and alanine aminotransferase levels; however, HDN treatment significantly reversed HC injury. Oxidative stress markers (malondialdehyde, superoxide dismutase, glutathioneand reactive oxygen species) were increased markedly during H/R in HCs; however, this effect was significantly attenuated after exposure to HDN. Compared with those of the control group, the mRNA expression levels of IL-6 and TNF-α in HCs and the concentrations of IL-6 and TNF-α in the supernatants increased significantly following H/R, and HDN significantly ameliorated these effects. Western blotting demonstrated that microtubule-associated protein 1 light chain 3α (MAP1LC3A, also known as LC3) and Beclin-1 protein expression levels increased, while sequestosome 1 levels decreased during H/R following exposure to HDN. The number of GFP-LC3 puncta in HCs following exposure to HDN was increased compared with that observed in HCs without HDN exposure under the H/R conditions after bafilomycin A1 treatment. In summary, the present study demonstrated that HDN attenuated HC oxidative stress and inflammatory responses while enhancing autophagy during H/R. HDN may have a potential protective effect on HCs during H/R-induced injury.

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“…It reduces the depressive symptoms by modulating the kappa-opioid and serotonergic 5-HT 1A receptors [3]. HESP antidepressant effect was demonstrated on mice exposed to chronic unpredictable mild stress [10]. Based on its powerful memory-enhancing and antioxidant benefits, it has the potential to be used as a treatment for Alzheimer's disease and dementia.…”

Section: Introductionmentioning

confidence: 99%

Rapid Voltammetric Screening Method for the Assessment of Bioflavonoid Content Using the Disposable Bare Pencil Graphite Electrode

et al. 2021

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Hesperidin (HESP) is a plant bioflavonoid found in various nutritional and medicinal products. Many of its multiple health benefits rely on the compound’s antioxidant ability, which is due to the presence of oxidizable hydroxyl groups in its structure. Therefore, the present study aimed to investigate the electrochemical behavior of HESP at a cheap, disposable pencil graphite electrode (PGE) in order to develop rapid and simple voltammetric methods for its quantification. Cyclic voltammetric investigations emphasized a complex electrochemical behavior of HESP. The influence of the electrode material, solution stability, supporting electrolyte pH, and nature were examined. HESP main irreversible, diffusion-controlled oxidation signal obtained at H type PGE in Britton Robinson buffer pH 1.81 was exploited for the development of a differential pulse voltammetry (DPV) quantitative analysis method. The quasi-reversible, adsorption-controlled reduction peak was used for HESP quantification by differential pulse adsorptive stripping voltammetry (DPAdSV). The linear ranges of DPV and DPAdSV were 1.00 × 10−7–1.20 × 10−5 and 5.00 × 10−8–1.00 × 10−6 mol/L with detection limits of 8.58 × 10−8 and 1.90 × 10−8 mol/L HESP, respectively. The DPV method was applied for the assessment of dietary supplements bioflavonoid content, expressed as mg HESP.

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The Anti-Depressive Effects of Hesperidin and the Relative Mechanisms Based on the NLRP3 Inflammatory Signaling Pathway

Cited by 51 publications

References 48 publications

Xiaoyaosan Exerts Antidepressant Effect by Downregulating RAGE Expression in Cingulate Gyrus of Depressive-Like Mice

Xiaoyaosan Exerts Antidepressant Effect by Downregulating RAGE Expression in Cingulate Gyrus of Depressive-Like Mice

Potential protective effect of hesperidin on hypoxia/reoxygenation‑induced hepatocyte injury

Rapid Voltammetric Screening Method for the Assessment of Bioflavonoid Content Using the Disposable Bare Pencil Graphite Electrode

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