The anti-dyslipidemia property of saffron petal hydroalcoholicextract in cardiovascular patients: A double-blinded randomized clinical trial

Toba, Kenji; Mollaei, Homa; Takhviji, Vahideh; Bijari, Bita; Zarban, Asghar; Rostami, Zahra; Hoshyar, Reyhane

doi:10.1016/j.clnesp.2023.04.002

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…The next material delivered by counselors in nutrition counseling is related to physical activity. Currently the high mortality rate is a result of diseases due to lifestyle changes and lack of physical activity as well as possible stress factors as risk factors (Kazemi et al, 2023). Therefore, physical activity material is important to be delivered in nutritional counseling related to the effect of physical activity on lipid profiles.…”

Section: Figure 5 Progress Of Triglicerides Valuesmentioning

confidence: 99%

“…Obesity is a health problem that occurs in many modern times and its incidence every year continues to increase (Katsuyama et al, 2022). Obesity with dyslipidemia can endanger health because it is a risk factor for various degenerative and metabolic diseases such as cardiovascular, diabetes mellitus, cancer, osteoarthritis (Kazemi et al, 2023). Obesity with dyslipidemia occurs due to an imbalance of incoming energy and outgoing energy.…”

Section: Introductionmentioning

confidence: 99%

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Nutrition Counseling, Lipid Profile Improvement and Weight Loss in Obese Patients with Dyslipidemia

Salman,

Hadi,

Ntau

et al. 2023

j. info kesehat.

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Obesity with dyslipidemia is a serious problem because it risks various degenerative and metabolic diseases. The prevalence of obesity in Indonesia continues to increase every year, currently in the adult population reaching 21.8%. To prevent the onset of degenerative diseases and metabolic disorders, it is important to control obesity with dyslipidemia through weight loss and lipid profile improvement. This study aims to determine the effect of nutritional counseling in losing weight and improving lipid profiles in obese patients with dyslipidemia. This is a pseudo-experimental study with One group Pre and Post Test Design. The initial stage was the identification of obesity and lipid profile. In 100 respondents identified as obese, total cholesterol, LDL and triglycerides were examined. 40 obese respondents with dyslipidemia were determined as samples. The second stage was nutrition counseling intervention. The third stage of evaluation is the re-measurement of body weight and lipid profile. The research result is only 30 respondents participated in the evaluation. Average initial body weight was 75.11 kg and final body weight was 73.14 kg. Average weight loss was 1.97 kg. Average initial cholesterol 233.20 mg/dL and final cholesterol 224.70 mg/dL. Average cholesterol reduction of 8.5 mg/dL. Average initial LDL 152.37 mg/dL and final LDL 139.47 mg/dL. Average decrease in LDL 12.9 mg/dL Average initial triglycerides 161.23 mg/dL and final triglycerides 143.97 mg/dL. The average decrease in triglycerides is 17.26 mg/dL. The statistical test results showed a p-value = 0.000. There is an effect of nutritional counseling on weight loss and improvement of lipid profiles of obese patients with dyslipidemia.

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Section: Figure 5 Progress Of Triglicerides Valuesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nutrition Counseling, Lipid Profile Improvement and Weight Loss in Obese Patients with Dyslipidemia

Salman,

Hadi,

Ntau

et al. 2023

j. info kesehat.

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Insights into phytochemistry and bioactive potential of saffron (Crocus sativus L) petal

Qadir,

Nissar,

Dar

et al. 2024

Future Postharvest and Food

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The principal by‐product of saffron processing, which is produced at a large level but has little market value, is saffron petals. Numerous constituents with profound bioactive potential, including safranal, crocin, picrocin, anthocyanins, glycosides, alkaloids, and kaempferol, are present in saffron petals. Saffron petal is an appropriate substitute for a variety of uses because it is less expensive and produced in greater quantities than saffron stigma. In this review, many pharmaceutical characteristics of the saffron petal have been discussed, including its anti‐bacterial, antifungal, antispasmodic, immunomodulatory, antidepressant, antinociceptive, hepatoprotective, renoprotective, antihypertensive, antidiabetic, and antioxidant activity. This review also provides insight into the pharmacological characteristics of saffron and its components along with the related mechanisms of action.

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Effects of saffron (Crocus sativus L.) supplementation on cardiometabolic Indices in diabetic and prediabetic overweight patients: a systematic review and meta-analysis of RCTs

Karim,

Pirzad,

Shirsalimi

et al. 2024

Diabetol Metab Syndr

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Background The incidence of diabetes mellitus (DM) is increasing worldwide, and there is growing interest in the potential use of natural compounds as an alternative treatment for managing DM. Several research studies have investigated the impact of saffron consumption on managing and improving metabolic profiles in patients with DM, and they have shown promising results. Object The study aims to systematically review and perform a meta-analysis to evaluate the potential effects of saffron and its extract on cardiometabolic indicators in diabetic and prediabetic overweight patients. Methods We conducted a comprehensive systematic review and meta-analysis, searching PubMed, Scopus, Web of Science, Embase, and Google Scholar for all relevant studies published before April 20, 2024. We extracted weighted (WMD) or standardized (SMD) mean differences (before-after) and 95% confidence intervals (95%CI) of the outcomes and conducted meta-analyses using R. The study protocol was registered in PROSPERO (CRD42024538380). Results Out of the studies screened, 15 RCTs were selected for inclusion in the systematic review and meta-analysis. These studies collectively involved 869 participants, 438 in the intervention group and 431 in the control group. Notably, our results showed that saffron supplementation led to significant changes in FBS (MD: − 8.75 mg/dL, 95% CI [− 14.75; − 2.76], P < 0.01), HbA1C (MD: − 0.34%, 95% CI [− 0.39; − 0.9], P < 0.01), TG (MD: − 13.28 mg/dL, 95% CI [− 22.82; − 3.75], P < 0.01), SBP (MD: − 5.33 mmHg, 95% CI [− 8.99–1.67], P = 0.04), DBP (MD: − 1.02 mmHg, 95% CI [− 3.91; 1.86], P = 0.03), AST (MD: − 1.32 IU/L, 95% CI [− 1.72, − 0.93], P < 0.01) levels in T2DM patients compared to placebo or no supplementation, indicating its potential as a therapeutic intervention. However, there was no significant effect on Insulin secretion (MD: − 0.15 µU/ml, 95% CI [− 2.1763; 1.8689], P = 0.88), HOMA (MD: − 0.35%, 95% CI [− 1.34;0.63], P = 0.48), TC (MD: − 4.86 mg/dL, 95% CI [− 9.81–0.09], P = 0.54), HDL (MD: 0.18 mg/dL, 95% CI [− 0.93; 1.29], P = 0.74), LDL (MD: − 1.77 mg/dL, 95% CI [− 5.99–2.45], P = 0.41), TNF-α (MD: − 0.34 pg/mL, 95% CI [− 0.99–0.30], P = 0.29), creatinine (MD: 2.83 mg/dL, 95% CI [2.29, 3.37], P = 0.31) and BUN (MD: − 0.44 mg/dL, 95% CI [− 1.43, 0.55], P = 0.38). Conclusion Saffron may improve specific CMI indices in overweight patients with diabetes or prediabetes, including significant reductions in FBS, HbA1C, TG, SBP, and AST. However, it did not significantly affect HDL, TC, LDL, insulin secretion, HOMA, DBP, TNF-α, ALT, Cr, or BUN. Further research with more trials and extended follow-up periods is needed to confirm and expand these findings.

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The anti-dyslipidemia property of saffron petal hydroalcoholicextract in cardiovascular patients: A double-blinded randomized clinical trial

Cited by 4 publications

References 21 publications

Nutrition Counseling, Lipid Profile Improvement and Weight Loss in Obese Patients with Dyslipidemia

Nutrition Counseling, Lipid Profile Improvement and Weight Loss in Obese Patients with Dyslipidemia

Insights into phytochemistry and bioactive potential of saffron (Crocus sativus L) petal

Effects of saffron (Crocus sativus L.) supplementation on cardiometabolic Indices in diabetic and prediabetic overweight patients: a systematic review and meta-analysis of RCTs

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