The Anti‐Endotoxin Activity of Taurolin in Experimental Animals

Pfirrmann, R. W.; Leslie, George B.

doi:10.1111/j.1365-2672.1979.tb02586.x

Cited by 38 publications

(11 citation statements)

References 2 publications

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“…Therefore, we conclude that intraperitoneal application of a single dose of taurolidine is inappropriate for bacterial kill ing. Taurolidine is known to inactivate endo toxins in vitro [22] as well as in vivo [30] which is corroborated by the results of our study. The endotoxin concentrations in the abdominal cavity and in plasma in the taurolidine-treated group were significantly lower than those in the saline group in the first 6 h.…”

Section: Discussionsupporting

confidence: 82%

Effect of Intraperitoneal Antimicrobials on the Concentration of Bacteria, Endotoxin, and Tumor Necrosis Factor in Abdominal Fluid and Plasma in Rats

Rosman

Westerveld²,

Oeveren³

et al. 1996

Eur Surg Res

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The efficacy of intraperitoneal instillation of antimicrobial agents in eliminating the bacterial contaminant in patients with generalized peritonitis remains controversial. We determined the effect of intraperitoneal instillation of taurolidine or imipenem on mortality, and on the concentration of bacteria, endotoxin, and tumor necrosis factor (TNF) in rats with intraperitoneally injected bacteria. Thirty rats were inoculated intraperitoneally with two enteric bacterial strains, followed by either taurolidine, saline, or imipenem. Abdominal fluid and blood were analyzed at different time intervals. The survival rate was highest in the imipenem group (p < 0.05). The bacterial concentration in abdominal fluid in the taurolidine and imipenem group was lower than in the saline group (p < 0.005), but the concentration in the imipenem group was lowest (p < 0.005). The endotoxin concentration in abdominal fluid and plasma in the taurolidine group was lower than in the other two groups (p < 0.05). The TNF concentration in abdominal fluid and plasma in the taurolidine group was lower than in the saline group (p < 0.05), whereas the concentration in the imipenem group was higher (p < 0.005). We conclude that topically applied taurolidine in rats with intraperitoneally injected bacteria may have a weak antibacterial effect, and lowered concentrations of endotoxin and TNF. Topically applied imipenem had a profound bactericidal activity but induced endotoxin and TNF release.

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Section: Discussionsupporting

confidence: 82%

Effect of Intraperitoneal Antimicrobials on the Concentration of Bacteria, Endotoxin, and Tumor Necrosis Factor in Abdominal Fluid and Plasma in Rats

Rosman

Westerveld²,

Oeveren³

et al. 1996

Eur Surg Res

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show abstract

“…Similar to CHX, taurolidine generally did not show any bacterial resistance due to this relatively unspecific pathway [34,35]. Since it is used in abdominal surgery and on mucous membranes, it can be suggested that it can be irrigated on mucosal tissues without damage to soft tissues or bone.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial effect of taurolidine (2%) on established dental plaque biofilm

2011

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Preliminary data have suggested that taurolidine may bear promising disinfectant properties for the therapy of bacterial infections. However, at present, the potential antibacterial effect of taurolidine on the supragingival plaque biofilm is unknown. To evaluate the antibacterial effect of taurolidine on the supragingival plaque biofilm using the vital fluorescence technique and to compare it with the effect of NaCl and chlorhexidine (CHX), 18 subjects had to refrain from all mechanical and chemical hygiene measures for 24 h. A voluminous supragingival plaque sample was taken from the buccal surfaces of the lower molars and wiped on an objective slide. The sample was then divided into three equal parts and mounted with one of the three test or control preparations (a) NaCl, (b) taurolidine 2% and (c) CHX 0.2%. After a reaction time of 2 min, the test solutions were sucked of. Subsequently, the plaque biofilm was stained with fluorescence dye and vitality of the plaque flora was evaluated under the fluorescence microscope (VF%). Plaque samples treated with NaCl showed a mean VF of 82.42 ± 6.04%. Taurolidine affected mean VF with 47.57 ± 16.60% significantly (p < 0.001, paired t test). The positive control CHX showed the lowest mean VF values (34.41 ± 14.79%; p < 0.001 compared to NaCl, p = 0.017 compared to taurolidine). Taurolidine possesses a significant antibacterial effect on the supragingival plaque biofilm which was, however, not as pronounced as that of CHX.

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“…CLS is a mixture of taurolidine -an antimicrobial substance -, citric acid and citrate for anticoagulation. Taurolidine is a unique nontoxic substance with antimicrobial [2], antimycotic [3], antiadherent [4] and antiendotoxic [5] properties. It is effective against multiresistant bacteria [6] and also inhibits staphylococcus coagulase [7], a clotting activator not inhibited by heparin, hirudin or antithrombin.…”

Section: Methodsmentioning

confidence: 99%