The Anti-Helicobacter pylori Flavones in a Brazilian Plant, Hyptis fasciculata, and the Activity of Methoxyflavones

Abstract

Two known flavonoids were isolated from a tropical medicinal plant, Hyptis fasciculata (Labiatae), found in Brazil. Flavonoids were identified as cirsilineol (1) and cirsimaritin (2) by spectroscopic means and were exhibited potent antibacterial activity against Helicobacter pylori, and cirsilineol (1) had weak antibacterial activity against Escherichia coli and Salmonella enteritidis. Following up on the relationship between anti-H. pylori activity and flavonoids with methoxy groups, several methoxy flavonoids were evaluated for proliferation of H. pylori.

In vitro anti-staphylococcal activity of Hyptis martiusii Benth against methicillin-resistant Staphylococcus aureus: MRSA strains

“…These antimicrobial properties have been assayed and proven in ethanol extracts and essential oils of H. ovalifolia (Hasimoto and Souza et al, 2002;Souza et al, 2003), in methylene chloride extract from H. brevipes (Goun et al, 2003). Furthermore, fl avones from H. suaveolans (Isobe et al, 2006) the strong anti-staphylococcal property of the ethanol extract of H. martiusii, noted by small MIC value and effectiveness in inhibiting the microbial growth of S. aureus. These data are promising and could encourage further researches on phytochemical, toxicological and pharmacological aspects of H. martiusii by-products in order to support their possible rational use in the antimicrobial therapy, particularly, in anti-S. aureus therapy.…”

“…Chemical compounds as fl avonoids (Isobe et al, 2006), triterpenes (Falcão et al, 2003), diterpenes (Ohsaki et al, 2005) and sesquiterpenes (Facey et al, 2005), with antimicrobial, insecticidal, analgesic, antiplasmodial activities and antidepressive effect (Okiemy-Andissa et al, 2004;Fragoso-Serrano et al, 2005;Chukwujekwu et al, 2005;Isobe et al, 2006;Silva et al, 2006;Bueno et al, 2006) were isolated on other plants from the genus Hyptis.…”

In vitroadditive effect ofHyptis martiusiiin the resistance to aminoglycosides of methicillin-resistantStaphylococcus aureus

“…Antitumor, cytotoxic, antibacterial, phototoxic, and insecticidal activities were identified (Araújo et al, 2003(Araújo et al, , 2006Costa-Lotufo et al, 2004;Costa et al, 2005;Coutinho et al, 2008b. With other plants from the genus Hyptis were isolated chemical compounds such as flavonoids (Isobe et al, 2006), diterpenes (Ohsaki et al, 2005) and sesquiterpenes (Facey et al, 2005), with antimicrobial, insecticidal, analgesic, and antiplasmodial activity (Okiemy-Andissa et al, 2004;Chukwujekwu et al, 2005;Fragoso-Serrano et al, 2005). Leaves, stems and fruits from these plants are used alone or combination by several populations as a popular remedy.…”

Antimicrobial activity of the crude ethanol extract fromHyptidendron canumleaves

“…Some flavonoids present antitumoral action as well as being able to act as antiviral, antihemorrhagic, hormonal, anti-inflammatory, antimicrobial, and antioxidizing agents. Isobe et al (2006) verified potent antimicrobial activity in the two isolated flavonoids of Hyptis fasciculata Benth. (Lamiaceae) cirsilineol and cirsimaritin against Helicobacter pylori.…”