The anti-HIV potential of imidazole, oxazole and thiazole hybrids: A mini-review

Development of novel isatin thiazolyl-pyrazoline hybrids as promising antimicrobials in MDR pathogens

“…20 Similarly, thiazoles, have exhibited antimicrobial, 21,22 anti-tuberculosis, 23 and antiviral activities. 24,25 Remarkably, compounds that contain thiazolyl-pyrazolines ( V , Fig. 1) moieties showed effective inhibition against methicillin-susceptible/-resistant S. aureus , and vancomycin-intermediate S. aureus .…”

Drug Design, Molecular Docking and Molecular Dynamics Simulations of Indole Class HIV‐1 NNRTIs Explored with QSAR and Topomer Search

“…And the ideal model needs to meet R 2 pred greater than 6, both the value of r m 2 and r m '2 are higher than 0.5, k and k' are in the range of 0.85 and 1.15, Δr m 2 is lower 0.2, r 2 m larger than 0.5. [27][28][29] Furthermore, the most significant external prediction parameters R 2 pred of the model is calculated as follows: [20,30]…”

“…Among the regions affected by AIDS, Africa has the highest number of people living with AIDS at 25.6 million, accounting for nearly 60 % of new global HIV infections [1] . To date, there is still no safe vaccine against AIDS, the highly active antiretroviral therapy (HAART) is a treatment that can significantly lower the mortality rate of AIDS patients by turning a once fatal disease into a manageable chronic one [2] …”

“…[1] To date, there is still no safe vaccine against AIDS, the highly active antiretroviral therapy (HAART) is a treatment that can significantly lower the mortality rate of AIDS patients by turning a once fatal disease into a manageable chronic one. [2] HIV-1 reverse transcriptase (RT) plays a crucial role in the replication of HIV-1. HIV-1 RNA is inverted into cDNA under the action of RT to form RNA-DNA intermediates, and the RNA-DNA intermediates then replicated into intact duplex DNA with the remaining cDNA as a template utilizing the hydrolysis of RT.…”

Metal-free electrochemical oxidative intramolecular cyclization ofN-propargylbenzamides: facile access to oxazole ketals

“…Oxazoles are desirable five-membered N,O-containing structural motifs widely present in a variety of natural and synthetic molecules with significant biological activities, such as antitumor, antifungal, and antiviral activities. 1 Moreover, oxazole frequently serves as a directing group, ligand, and versatile synthetic intermediate in modern organic chemistry. 2 Therefore, developing powerful, straightforward, and sustainable strategies toward the construction of functionalized oxazoles from easily accessible starting materials is highly desirable for synthetic chemistry and drug discovery.…”