The anti-inflammatory, anti-ulcer activities and phytochemical investigation of <i>Cucumis melo</i> L. cv. Ismailawi fruits

Moustafa, Sherifa F.; Gabr, Nagwan M.; Zaki, Jaky T; Awdan, Sally A. El; Mina, Suzan A.

doi:10.1080/14786419.2020.1803314

Cited by 10 publications

(8 citation statements)

References 13 publications

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“…The melon is, above all, water, depending on the varieties, the water percentage ranges between 90% and 95% (Gómez‐García et al., 2020). The consumption of melon enriches the blood in mineral salts and vitamins and facilitates the purifying work of the kidneys (Moustafa et al., 2020). After drinking melon water, the kidneys can more effectively eliminate waste substances and toxins that are produced as a result of metabolic activity, and melon juice contributes to this, along with the minerals it has dissolved (Moustafa et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

“…The consumption of melon enriches the blood in mineral salts and vitamins and facilitates the purifying work of the kidneys (Moustafa et al., 2020). After drinking melon water, the kidneys can more effectively eliminate waste substances and toxins that are produced as a result of metabolic activity, and melon juice contributes to this, along with the minerals it has dissolved (Moustafa et al., 2020). Likewise, the clarification of juices by conventional methods involves several separation stages such as filtration and decantation, in order to achieve the removal of suspended solids and colloidal particles that are considered undesirable for the final product.…”

Section: Introductionmentioning

confidence: 99%

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Impact of the melon juice clarification method on the physicochemical properties of an alcoholic beverage

Téllez‐Morales

Henández-Santos

Rodríguez‐Miranda

2021

J Food Process Preserv

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Melon (Cucumis melo L.) is a fruit that has many health benefits such as being hydrating, remineralizing, alkalizing, diuretic, and laxative, it also contains dietary fiber, energy, protein, vitamins, and minerals (Rodríguez-Luna et al., 2020). The melon is, above all, water, depending on the varieties, the water percentage ranges between 90% and 95% (Gómez-García et al., 2020). The consumption of melon enriches the blood in mineral salts and vitamins and facilitates the purifying work of the kidneys (Moustafa et al., 2020). After drinking melon water, the kidneys can more effectively eliminate waste substances and toxins that are produced as a result of metabolic activity, and melon juice contributes to this, along with the minerals it has dissolved (Moustafa et al., 2020). Likewise, the clarification of juices by conventional methods involves several separation stages such as filtration and decantation, in order to achieve the removal of suspended solids and colloidal particles that are considered undesirable for the final product. At an industrial level, clarified melon juice could be used in the manufacture of different products, such as juices, sweets, and marmalades, as well as alcoholic beverages considering its properties (Vaillant et al., 2001). Fruit liqueurs are among the most popular beverages made with fruits such as plums, apple, cherries, melon, citrus, and pear, in addition, the types of fruits and the production methods are of great importance for the quality of the final product (Śliwińska et al., 2015). Likewise, liqueurs are products made from distilled alcoholic beverages, neutral spirit, quality or common alcohol or a mixture of them and water, flavored with specific procedures and to which ingredients and additives allowed by the official Mexican standard can be added (NOM-142-SSA1-1995). In addition, the dose allowed for the consumption of an alcoholic drink, in a healthy human being and without additional

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of the melon juice clarification method on the physicochemical properties of an alcoholic beverage

Téllez‐Morales

Henández-Santos

Rodríguez‐Miranda

2021

J Food Process Preserv

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“…The mechanisms by which VA exerts its anti-inflammatory effects were confirmed in vivo in murine models of inflammatory pain (i.e., carrageenan-induced paw oedema model) by Calixto-Campos et al [ 185 ]. Vanillic acid and syringic acid were also the major identified phenolic acids in Cucumis melo L. fruits, which Moustafa et al [ 186 ] studied to assess their potential anti-inflammatory and anti-ulcer activities on carrageenan-induced rat paw oedema. The fruit pulp extracts showed a significant decrease in oedema volume and anti-ulcer activity (i.e., ulcer number and severity) after 4 h compared to the standard drugs.…”

Section: Hydroxycinnamic Acids and Derivatives: Activities On Skin Disordersmentioning

confidence: 99%

Hydroxycinnamic Acids and Derivatives Formulations for Skin Damages and Disorders: A Review

et al. 2021

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Alterations of skin homeostasis are widely diffused in our everyday life both due to accidental injuries, such as wounds and burns, and physiological conditions, such as late-stage diabetes, dermatitis, or psoriasis. These events are locally characterized by an intense inflammatory response, a high generation of harmful free radicals, or an impairment in the immune response regulation, which can profoundly change the skin tissue’ repair process, vulnerability, and functionality. Moreover, diabetes diffusion, antibiotic resistance, and abuse of aggressive soaps and disinfectants following the COVID-19 emergency could be causes for the future spreading of skin disorders. In the last years, hydroxycinnamic acids and derivatives have been investigated and applied in several research fields for their anti-oxidant, anti-inflammatory, and anti-bacterial activities. First, in this study, we give an overview of these natural molecules’ current source and applications. Afterwards, we review their potential role as valid alternatives to the current therapies, supporting the management and rebalancing of skin disorders and diseases at different levels. Also, we will introduce the recent advances in the design of biomaterials loaded with these phenolic compounds, specifically suitable for skin disorders treatments. Lastly, we will suggest future perspectives for introducing hydroxycinnamic acids and derivatives in treating skin disorders.

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“…Cantaloupe seeds were discovered to possess high levels of carbohydrates, fibers, proteins, and essential amino acids such as leucine, isoleucine, and phenylalanine (7). Cucumis melo L has been reported to exhibit antioxidant, cytotoxic (9,10), antimicrobial (5), anti-hyperlipidemic (11), diuretic, nephroprotective (12), anti-inflammatory, and anti-ulcer activities (13,14). Cucumis melo is rich in biologically active compounds that play a vital role in plant bioactivities (7,8).…”

Section: Introductionmentioning

confidence: 99%

Bioactivities, physicochemical parameters and GC/MS profiling of the fixed oil of Cucumis melo L seeds: A focus on anti-inflammatory, immunomodulatory, and antimicrobial activities

El-Anssary

Raoof

Saleh

et al. 2021

J Herbmed Pharmacol

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Introduction: Recently, the recovery of waste products from plants as a source of biologically active compounds has increased interest. Therefore, the current research aims to evaluate the anti-inflammatory, immunomodulatory and antimicrobial activities of the fixed oil of Cucumis melo L seeds, as well as to investigate its physicochemical parameters and chemical composition. Methods: Anti-inflammatory activity was examined using carrageenan-induced rat paw edema assay. The antimicrobial activity was assayed against Staphylococcus aureus, Micrococcus luteus, Enterococcus faecalis, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Candida albicans by well diffusion method. The chemical composition of the oil was determined by gas chromatography/mass spectrometry (GC/MS), α-tocopherol was estimated by high-performance liquid chromatography (HPLC). Results: Cucumis melo oil had no toxicity and possessed a promising anti-inflammatory activity. Moreover, the oil exhibited a reasonable decrease in the pro-inflammatory cytokines, including interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), and a significant increase in the anti-inflammatory cytokine (IL-10). The oil exhibited a reasonable antimicrobial activity against all tested organisms. The major identified compound in the unsaponifiable matter was (1-methyldodecyl) benzene (8.76%), while the major fatty acid was methyl linoleate (14.10%). The results of physicochemical characterization revealed the better quality of Cucumis melo oil. The amount of α-tocopherol in the oil was 23.5 μg/mL, which is considered a reasonable amount. Conclusion: These findings indicate that the fixed oil of Cucumis melo L seeds might be used as a safe natural anti-inflammatory, immunomodulatory and antimicrobial agent.

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The anti-inflammatory, anti-ulcer activities and phytochemical investigation of Cucumis melo L. cv. Ismailawi fruits

Cited by 10 publications

References 13 publications

Impact of the melon juice clarification method on the physicochemical properties of an alcoholic beverage

Impact of the melon juice clarification method on the physicochemical properties of an alcoholic beverage

Hydroxycinnamic Acids and Derivatives Formulations for Skin Damages and Disorders: A Review

Bioactivities, physicochemical parameters and GC/MS profiling of the fixed oil of Cucumis melo L seeds: A focus on anti-inflammatory, immunomodulatory, and antimicrobial activities

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