The Anti-Inflammatory Effect of Humulus lupulus Extract In Vivo Depends on the Galenic System of the Topical Formulation

Hurth, Zita; Faber, Marie-Luise; Gendrisch, Fabian; Holzer, Martin; Haarhaus, Birgit; Cawelius, Anja; Schwabe, Kay; Schempp, Christoph M.; Wölfle, Ute

doi:10.3390/ph15030350

Cited by 10 publications

(6 citation statements)

References 52 publications

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“…Hop extract has been found to possess various pharmacological properties. For instance, it exhibits antitumor and anti-inflammatory effects, as evidenced by previous studies [322]. Moreover, the extract has been reported to possess antibacterial, anticollagenase, and antioxidant activity [323].…”

Section: Humulus Lupulus L Hemp Family -Cannabaceaementioning

confidence: 63%

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Medicinal Plants of the Flora of Kazakhstan Used in the Treatment of Skin Diseases

Berganayeva¹,

Kudaibergenova²,

Litvinenko³

et al. 2023

Preprint

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According to the eminent scholar, philosopher, and physician Avicenna, "the doctor has three tools: the word, the plant, the knife." The plant kingdom is recognized as humanity's earliest and most ancient healing source, employed for the management and prevention of illnesses. Tracing back through history, the most ancient documented proof of plants' utilization in medicine dates back to a Sumerian clay slab discovered in Nagpur roughly 5000 years ago. This artifact included a compilation of twelve medicinal recipes that involved over 250 diverse plant species. Sumerian healers extracted powders and infusions from plant roots and stems, while also crediting healing properties to pears and figs. Additionally, they utilized dried and ground young shoots of willow and plum trees, pine and fir needles as a component in compresses and poultices. Often, powders from animal and mineral sources were blended with those extracted from dried and crushed plants. Notably, in addition to water, wine and beer served as solvents. Thus, at least 80 centuries ago, people utilized the most uncomplicated medicinal plant-based preparations for treatment [1]. The "Pen T'Sao," an ancient Chinese text on roots and herbs, authored by Emperor Shen Nung approximately 2500 BC, contains descriptions of 900 medicaments (comprising dried components of medicinal plants). Several of these substances are still in use today, including Rhei rhisoma, camphor, Theae folium, Podophyllum, great yellow gentian, ginseng, datura, cinnamon bark, and ephedra [2]. Regarding Kazakh folk medicine, an area that has yet to be fully explicated and substantiated, it can be stated that the traditional medicinal knowledge of the Kazakh people transcends the mere treatment of ailments and rests on robust theoretical underpinnings. Oteiboydak Tleukabyluly (1388-1478), an astute healer and prominent figure in Kazakh folk medicine during the 15th century, comprehensively explicated the secrets of the healing art in his medical and ethnographic work "Medical Narrative," which he composed between 1466 and 1473 at the behest of az-Zhanibek Khan, who held him in high esteem as a great healer. This medical encyclopedia delineates the functions of various organs of the human body and provides a catalogue of the primary diseases associated with them. Furthermore, it includes a meticulous description of the methods used in traditional medicine at present, such as setting bones, listening to the pulse, and incantations. Through practical experimentation and experimentation conducted in the steppe laboratory, the healer formulated a total of 1,108 different medicinal compounds, of which 858 were derived from medicinal plants, 318 were extracted from animal organs, and roughly 60 were sourced from metals. The moniker "Teacher without a teacher" was bestowed on Oteiboydak Tleukabylov, who discovered methods for treating 1,050 different diseases [3]. At present, the employment of phytotherapy has gained widespread acceptance on a global scale. According to the World Health Organization's (WHO) global review of national policies concerning traditional, complementary, and alternative medicine, as well as the regulation of herbal medicines, there is an evident growth in the European and Asian market for herbal medicines [4]. Kazakhstan boasts a natural flora of over 6,000 plant species [5]. The exact number of medicinal plant species present in Kazakhstan remains uncertain, as the list continues to expand annually. More than 150 plant species have been employed in both official and folk medicine for various ailments. This review focuses on a selection of medicinal plants growing within the territory of the Republic of Kazakhstan that have traditionally been used to alleviate skin diseases. In conducting this study (2010-2023), emphasis was placed on the plants' phytochemical composition, with a particular focus on the principal components responsible for their therapeutic effects against inflammatory skin conditions such as dermatitis, atopic dermatitis, and eczema.

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Section: Humulus Lupulus L Hemp Family -Cannabaceaementioning

confidence: 63%

“…In dermatology, extracts of H. lupulus have been employed as an antipsoriatic medication [322]. Furthermore, they are used in the management of inflammatory skin disorders in adolescents, and hop cones are taken orally to address baldness, furunculosis, lichen, and scrofula [318,323].…”

Section: Humulus Lupulus L Hemp Family -Cannabaceaementioning

confidence: 99%

Medicinal Plants of the Flora of Kazakhstan Used in the Treatment of Skin Diseases

Berganayeva¹,

Kudaibergenova²,

Litvinenko³

et al. 2023

Preprint

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show abstract

“…Hop extract has been found to possess various pharmacological properties. For instance, it exhibits antitumor and anti-inflammatory effects, as evidenced by previous studies [179]. Moreover, the extract has been reported to possess antibacterial, anti-collagenase, and antioxidant activity [180].…”

Section: Humulus Lupulus L Hemp Family-cannabaceaementioning

confidence: 64%

“…In dermatology, extracts of H. lupulus have been employed as an antipsoriatic medicine [ 179 ]. Furthermore, they are used in the treatment of skin inflammation diseases of adolescents, and hop cones are taken orally to cure baldness, furunculosis, lichen, and scrofula [ 175 , 180 ].…”

Section: Introductionmentioning

confidence: 99%

Medicinal Plants of the Flora of Kazakhstan Used in the Treatment of Skin Diseases

et al. 2023

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The skin shows the physiological condition of the body’s organs and systems that prevent infections and physical damage. Throughout the ages, in folk medicine, phytotherapy was considered a primary form of treatment in all countries, including Kazakhstan, due to the abundance and availability of plant-based remedies. This paper discusses several medicinal plants that are traditionally used in the treatment of skin diseases in the Republic of Kazakhstan. The chemical composition of these plants was analyzed, with a particular focus on the biologically active basic compounds responsible for their therapeutic efficiency in treating skin ailments.

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“…Recently, Hurth et al (2022) developed lipid-rich creams (oil-in-water (O/W) and a water-in-oil (W/O) emulsions) containing a bitter-acids-enriched CO 2 hop extract (1%, 10 mg/mL), testing them in a randomized placebo-controlled doubleblind UVB erythema study with 40 healthy volunteers, using hydrocortisone acetate (1%) as the positive control. The results demonstrated that only the O/W cream formulations exhibited an in vivo anti-inflammatory effect in the UVB erythema tests, probably due to the presence of penetration enhancers (e.g., propanediol) and the specific chemical profile of the extract in terms of solubility and lipophilicity of the bioactive components present in the galenic formulation tested [160]. Dabrowski et al (2022) conducted a clinical trial on 50 adult patients affected by acute respiratory failure caused by the COVID-19 infection, treating a group with an extract from H. lupulus rich in XN as adjuvant therapy (three times a day every 8 h at a dose of 1.5 mg/kg body weight, for 7 days) [161].…”

Section: Human Studies and Clinical Trial Evidence Of Hopsmentioning

confidence: 98%

An Updated Review of the Genus Humulus: A Valuable Source of Bioactive Compounds for Health and Disease Prevention

Carbone

Gervasi

2022

Plants

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The medicinal potential of hop (Humulus lupulus L.) is widely cited in ancient literature and is also allowed in several official pharmacopoeias for the treatment of a variety of ailments, mainly related to anxiety states. This is due to the plethora of phytoconstituents (e.g., bitter acids, polyphenols, prenyl flavonoids) present in the female inflorescences, commonly known as cones or strobili, endowed with anti-inflammatory, antioxidant, antimicrobial, and phytoestrogen activities. Hop has recently attracted the interest of the scientific community due to the presence of xanthohumol, whose strong anti-cancer activity against various types of cancer cells has been well documented, and for the presence of 8-prenyl naringenin, the most potent known phytoestrogen. Studies in the literature have also shown that hop compounds can hinder numerous signalling pathways, including ERK1/2 phosphorylation, regulation of AP-1 activity, PI3K-Akt, and nuclear factor NF-κB, which are the main targets of the antiproliferative action of bitter acids and prenylflavonoids. In light of these considerations, the aim of this review was to provide an up-to-date overview of the main biologically active compounds found in hops, as well as their in vitro and in vivo applications for human health and disease prevention. To this end, a quantitative literature analysis approach was used, using VOSviewer software to extract and process Scopus bibliometric data. In addition, data on the pharmacokinetics of bioactive hop compounds and clinical studies in the literature were analysed. To make the information more complete, studies on the beneficial properties of the other two species belonging to the genus Humulus, H. japonicus and H. yunnanensis, were also reviewed for the first time.

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The Anti-Inflammatory Effect of Humulus lupulus Extract In Vivo Depends on the Galenic System of the Topical Formulation

Cited by 10 publications

References 52 publications

Medicinal Plants of the Flora of Kazakhstan Used in the Treatment of Skin Diseases

Medicinal Plants of the Flora of Kazakhstan Used in the Treatment of Skin Diseases

Medicinal Plants of the Flora of Kazakhstan Used in the Treatment of Skin Diseases

An Updated Review of the Genus Humulus: A Valuable Source of Bioactive Compounds for Health and Disease Prevention

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