The Anti-Inflammatory Effect of Low Molecular Weight Fucoidan from Sargassum siliquastrum in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages via Inhibiting NF-κB/MAPK Signaling Pathways

Jayasinghe, Arachchige Maheshika Kumari; Kirindage, Kirinde Gedara Isuru Sandanuwan; Fernando, Ilekuttige Priyan Shanura; Kim, Kil-Nam; Oh, Jae-Young; Ahn, Ginnae

doi:10.3390/md21060347

Cited by 19 publications

(4 citation statements)

References 45 publications

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“…A similar effect was registered in in vitro and in vivo experiments with fucan extracted from Sargassum fusiforme, reducing not only pro-inflammatory cytokine levels but also NO and PGE 2 levels, and this was associated with NF-κB signaling modulation [67]. A fucan obtained from brown seaweed has been shown to have anti-inflammatory activity associated with the regulation of central signaling pathways, like MAPK and NF-κB, reducing phosphorylation of p38, ERK, JNK, p65, and IKKα/IKKβ [56,68], and NF-κB nuclear translocation [49] in in vitro and in vivo experiments.…”

Section: Discussionmentioning

confidence: 97%

Anti-Inflammatory Activity of Fucan from Spatoglossum schröederi in a Murine Model of Generalized Inflammation Induced by Zymosan

Silva,

Souza,

Silva

et al. 2023

Marine Drugs

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Fucans from marine algae have been the object of many studies that demonstrated a broad spectrum of biological activities, including anti-inflammatory effects. The aim of this study was to verify the protective effects of a fucan extracted from the brown algae Spatoglossum schröederi in animals submitted to a generalized inflammation model induced by zymosan (ZIGI). BALB/c mice were first submitted to zymosan-induced peritonitis to evaluate the treatment dose capable of inhibiting the induced cellular migration in a simple model of inflammation. Mice were treated by the intravenous route with three doses (20, 10, and 5 mg/kg) of our fucan and, 1 h later, were inoculated with an intraperitoneal dose of zymosan (40 mg/kg). Peritoneal exudate was collected 24 h later for the evaluation of leukocyte migration. Doses of the fucan of Spatoglossum schröederi at 20 and 10 mg/kg reduced peritoneal cellular migration and were selected to perform ZIGI experiments. In the ZIGI model, treatment was administered 1 h before and 6 h after the zymosan inoculation (500 mg/kg). Treatments and challenges were administered via intravenous and intraperitoneal routes, respectively. Systemic toxicity was assessed 6 h after inoculation, based on three clinical signs (bristly hair, prostration, and diarrhea). The peritoneal exudate was collected to assess cellular migration and IL-6 levels, while blood samples were collected to determine IL-6, ALT, and AST levels. Liver tissue was collected for histopathological analysis. In another experimental series, weight loss was evaluated for 15 days after zymosan inoculation and fucan treatment. The fucan treatment did not present any effect on ZIGI systemic toxicity; however, a fucan dose of 20 mg/kg was capable of reducing the weight loss in treated mice. The treatment with both doses also reduced the cellular migration and reduced IL-6 levels in peritoneal exudate and serum in doses of 20 and 10 mg/kg, respectively. They also presented a protective effect in the liver, with a reduction in hepatic transaminase levels in both doses of treatment and attenuated histological damage in the liver at a dose of 10 mg/kg. Fucan from S. schröederi presented a promising pharmacological activity upon the murine model of ZIGI, with potential anti-inflammatory and hepatic protective effects, and should be the target of profound and elucidative studies.

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Section: Discussionmentioning

confidence: 97%

Anti-Inflammatory Activity of Fucan from Spatoglossum schröederi in a Murine Model of Generalized Inflammation Induced by Zymosan

Silva,

Souza,

Silva

et al. 2023

Marine Drugs

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show abstract

“…NF-κB is a transcription factor involved in inflammation and insulin resistance. Algae-derived compounds, including phlorotannins from Ecklonia cava [ 134 ] and fucoidan from brown algae (for example, Sargassum siliquastrum ) [ 135 ], have demonstrated anti-inflammatory effects by suppressing NF-κB activation. Inhibition of the NF-κB signaling pathway alleviates inflammation and improves insulin sensitivity.…”

Section: Mechanistic Insights and Molecular Targetsmentioning

confidence: 99%

Algae-Derived Natural Products in Diabetes and Its Complications—Current Advances and Future Prospects

Pereira,

Valado

2023

Life

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Diabetes poses a significant global health challenge, necessitating innovative therapeutic strategies. Natural products and their derivatives have emerged as promising candidates for diabetes management due to their diverse compositions and pharmacological effects. Algae, in particular, have garnered attention for their potential as a source of bioactive compounds with anti-diabetic properties. This review offers a comprehensive overview of algae-derived natural products for diabetes management, highlighting recent developments and future prospects. It underscores the pivotal role of natural products in diabetes care and delves into the diversity of algae, their bioactive constituents, and underlying mechanisms of efficacy. Noteworthy algal derivatives with substantial potential are briefly elucidated, along with their specific contributions to addressing distinct aspects of diabetes. The challenges and limitations inherent in utilizing algae for therapeutic interventions are examined, accompanied by strategic recommendations for optimizing their effectiveness. By addressing these considerations, this review aims to chart a course for future research in refining algae-based approaches. Leveraging the multifaceted pharmacological activities and chemical components of algae holds significant promise in the pursuit of novel antidiabetic treatments. Through continued research and the fine-tuning of algae-based interventions, the global diabetes burden could be mitigated, ultimately leading to enhanced patient outcomes.

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“…NF-κB is a transcription factor involved in inflammation and insulin resistance. Algae-derived compounds, including phlorotannins from Ecklonia cava [134] and fucoidan from brown algae (for example, Sargassum siliquastrum) [135], have demonstrated antiinflammatory effects by suppressing NF-κB activation. Inhibition of the NF-κB signaling pathway alleviates inflammation and improves insulin sensitivity.…”

Section: Nuclear Factor-kappa B (Nf-κb)mentioning

confidence: 99%

Unlocking Nature's Treasures: Algae-Derived Natural Products in Diabetes and Its Complications - Current Advances and Future Prospects

Pereira¹,

Valado²

2023

Preprint

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Diabetes and its complications are a global health burden, necessitating novel therapeutic approaches. Natural products and derivatives are gaining attention as potential agents for managing diabetes due to their diverse constituents and pharmacological activities. Algae, in particular, offer promising bioactive compounds with antidiabetic properties. This review provides an overview of natural products derived from algae in diabetes management, including advancements and future prospects. It highlights the significance of natural products in diabetes, explores algae's diversity, bioactive compounds, and mechanisms of action. The challenges, limitations, and strategies for optimizing algae-based interventions are discussed, alongside future research directions. Algae's multifaceted pharmacological activities and chemical constituents make them attractive for developing novel antidiabetic therapeutics. Further research and optimization of algae-based interventions have the potential to address the global burden of diabetes and improve patient outcomes.

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The Anti-Inflammatory Effect of Low Molecular Weight Fucoidan from Sargassum siliquastrum in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages via Inhibiting NF-κB/MAPK Signaling Pathways

Cited by 19 publications

References 45 publications

Anti-Inflammatory Activity of Fucan from Spatoglossum schröederi in a Murine Model of Generalized Inflammation Induced by Zymosan

Anti-Inflammatory Activity of Fucan from Spatoglossum schröederi in a Murine Model of Generalized Inflammation Induced by Zymosan

Algae-Derived Natural Products in Diabetes and Its Complications—Current Advances and Future Prospects

Unlocking Nature's Treasures: Algae-Derived Natural Products in Diabetes and Its Complications - Current Advances and Future Prospects

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