The anti-inflammatory effects of aerobic exercise training in patients with type 2 diabetes: A systematic review and meta-analysis

Papagianni, Georgia; Panayiotou, Chrystalla; Vardas, Michail; Balaskas, Nikolaos; Antonopoulos, Constantinos; Tachmatzidis, Dimitrios; Didangelos, Triantafyllos; Lambadiari, Vaia; Kadoglou, Nikolaos P.E.

doi:10.1016/j.cyto.2023.156157

Cited by 23 publications

(15 citation statements)

References 69 publications

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“… 20 Sufficient PA has shown as an effective way to improve oral and systemic health through reducing inflammation and boosting immune system. 21 , 22 , 23 …”

Section: Discussionmentioning

confidence: 99%

Does the guideline-based physical activity level for cardiovascular health also benefit periodontal health?

Tsai

Huang

Wang

et al. 2024

Journal of Dental Sciences

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“… 20 Sufficient PA has shown as an effective way to improve oral and systemic health through reducing inflammation and boosting immune system. 21 , 22 , 23 …”

Section: Discussionmentioning

confidence: 99%

Does the guideline-based physical activity level for cardiovascular health also benefit periodontal health?

Tsai

Huang

Wang

et al. 2024

Journal of Dental Sciences

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“…An acute increase in circulating IL-6 is induced following high-intensity interval exercise ( Cullen et al, 2016 ; Ostrowski, Schjerling & Pedersen, 2000 ). Aerobic exercise significantly reduces the inflammatory load in type 2 diabetes by improving circulating levels of factors such as resistin, TNF-α, and IL-6 ( Papagianni et al, 2023 ). On the other hand, resistance training, characterized by high-intensity muscle contractions, suppresses the release of MSTN ( Khalafi et al, 2023 ).…”

Section: Survey Methodologymentioning

confidence: 99%

“…In recent years, growing evidence indicates that aerobic exercise plays a pivotal role as an effective therapy for the anti-inflammatory strategy ( Papagianni et al, 2023 ). These studies highlight the profound impact of exercise on modulating the body’s inflammatory processes, further underscoring the importance of physical activity in promoting overall health and well-being ( Joisten et al, 2019 ; Lavin et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Exploring exercise-driven exerkines: unraveling the regulation of metabolism and inflammation

Zhou,

Gong,

Zhang

et al. 2024

PeerJ

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Exercise has many beneficial effects that provide health and metabolic benefits. Signaling molecules are released from organs and tissues in response to exercise stimuli and are widely termed exerkines, which exert influence on a multitude of intricate multi-tissue processes, such as muscle, adipose tissue, pancreas, liver, cardiovascular tissue, kidney, and bone. For the metabolic effect, exerkines regulate the metabolic homeostasis of organisms by increasing glucose uptake and improving fat synthesis. For the anti-inflammatory effect, exerkines positively influence various chronic inflammation-related diseases, such as type 2 diabetes and atherosclerosis. This review highlights the prospective contribution of exerkines in regulating metabolism, augmenting the anti-inflammatory effects, and providing additional advantages associated with exercise. Moreover, a comprehensive overview and analysis of recent advancements are provided in this review, in addition to predicting future applications used as a potential biomarker or therapeutic target to benefit patients with chronic diseases.

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“…Der beim Typ-2-Diabetes den kardiovaskulären, renalen und ophthalmischen Folgeschäden, aber auch der Insulinresistenz und dem β-Zellversagen unterliegende "Low Grade"-Entzündungszustand kann durch körperliches Training beeinflusst werden. Eine aktuelle Metaanalyse mit 26 eingeschlossenen randomisierten kontrollieren Studien (RCT) und 1239 Patienten [19] konnte zeigen, dass ein aerobes Ausdauertraining trotz einer nur geringen Abnahme des BMI zu einer Reduktion von Nüchternglukose, C-reaktivem Protein (CRP), Tumornekrosefaktorα (TNF-α), Resistin und Interleukin-6 (IL-6) im Serum führt. Erklärt werden kann die anti-inflammatorische Wirkung durch den positiven Effekt auf die ektopen Lipiddepots [20] und die einem Belastungsreiz im Skelettmuskel folgende Expression von IL-6, das TNF-α und Interleukin (IL)-1β-Signaling inhibiert.…”

Section: Anti-inflammatorische Effekteunclassified

Körperliche Aktivität und Trainingstherapie bei Typ-2-Diabetes – ein Update

Nieß,

Thiel

2024

Diabetologie und Stoffwechsel

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Regelmäßige körperliche Aktivität und Training besitzen bei Menschen mit Typ-2-Diabetes ein breites Wirkspektrum. Günstige Effekte auf die glykämische Stoffwechsellage sind ebenso nachgewiesen wie die Absenkung des aufgrund der Erkrankung erhöhten kardiovaskulären Risikos. Die Empfehlung zu regelmäßiger körperlicher Aktivität bei Patienten mit Typ-2-Diabetes ist in den Leitlinien abgebildet und sollte bei der Betreuung der Betroffenen Beachtung finden.Bibliografie

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The anti-inflammatory effects of aerobic exercise training in patients with type 2 diabetes: A systematic review and meta-analysis

Cited by 23 publications

References 69 publications

Does the guideline-based physical activity level for cardiovascular health also benefit periodontal health?

Does the guideline-based physical activity level for cardiovascular health also benefit periodontal health?

Exploring exercise-driven exerkines: unraveling the regulation of metabolism and inflammation

Körperliche Aktivität und Trainingstherapie bei Typ-2-Diabetes – ein Update

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