The anti-inflammatory effects of baicalin through suppression of NLRP3 inflammasome pathway in LPS-challenged piglet mononuclear phagocytes

Yuan, Chun; Li, Sali; Yao, Wenxu; Xu, Lei; Qiu, Yinsheng; Liu, Yu; Wu, Zhongyuan; Hou, Yongqing

doi:10.1177/1753425916631032

Cited by 32 publications

(34 citation statements)

References 32 publications

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“…Baicalin, one of the flavonoid compounds, is a major active ingredient in Chinese medicinal plant Radix Scutellariae (Huangqin). 7) Baicalin has various pharmacological activities, such as anti-inflammation, anti-oxidation, anti-cancer and anti-viral. [8][9][10][11] Previous study has revealed that baicalin has anti-adipogenic effect, anti-oxidation and anti-inflammatory effect in AS.…”

Section: Introductionmentioning

confidence: 99%

Baicalin Suppresses the Proliferation and Migration of Ox-LDL-VSMCs in Atherosclerosis through Upregulating miR-126-5p

Chen

Pan

Sheng

et al. 2019

Biological & Pharmaceutical Bulletin

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Atherosclerosis (AS) is a chronic inflammatory disease threatening human health, and vascular smooth muscle cells (VSMCs) are involved in AS processes. Baicalin is a flavonoid compound, which has antiatherosclerotic effect. The aim of our study was to explore the molecular mechanism of baicalin on AS. The expression of miR-126-5p was measured in peripheral blood of AS patients and healthy control. We found miR-126-5p expression was decreased in AS. Then, high-mobility group box 1 (HMGB1) was verified as a target of miR-126-5p and its expression was increased in AS. Similarly, miR-126-5p and HMGB1 expression was downregulated and upregulated in oxidized low-density lipoprotein treated VSMCs (ox-LDL-VSMCs), respectively. Furthermore, baicalin upregulated miR-126-5p and downregulated HMGB1 expression. Functionally, baicalin significantly inhibited ox-LDL-VSMCs proliferation and migration, and miR-126-5p targets HMGB1 to enhance the inhibition induced by baicalin. Taken together, baicalin is able to prevent AS, which suppressed the proliferation and migration of ox-LDL-VSMCs through upregulating miR-126-5p by targeting HMGB1. These findings suggested that baicalin is an effective drug to alleviate AS, and miR-126-5p is a novel therapeutic target for AS.

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Section: Introductionmentioning

confidence: 99%

Baicalin Suppresses the Proliferation and Migration of Ox-LDL-VSMCs in Atherosclerosis through Upregulating miR-126-5p

Chen

Pan

Sheng

et al. 2019

Biological & Pharmaceutical Bulletin

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“…Anti-in ammatory effects of baicalin in vitro and in vivo have been reported before [9,10]. In this study, we investigated whether baicalin affected the expression of pro-in ammatory cytokines and IFN-β in virus-infected CEF cells.…”

Section: No Effect Of Baicalin On Pro-in Ammatory Cytokines and Ifn-βmentioning

confidence: 99%

Antiviral effect of baicalin on Marek’s disease virus in CEF cells

Yang

Feng

Yao

et al. 2020

Preprint

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Background: Baicalin, the main metabolic component of S.baicalensis Georgi, has various pharmacological properties including anti-inflammatory, anti-oxidant, anti-apoptotic, anti-bactericidal and anti-viral. The purpose of this study was to investigate the anti-Marek’s disease virus (MDV) activities of baicalin in CEF cells.Results: Here, we showed that baicalin could inhibit viral mRNA, protein levels and overall plaque formation in a time-dependent manner. We also found that baicalin could consistently inhibit MDV replication and directly affect the virus infectivity. Moreover, baicalin treatment has no effect on expression level of antiviral cytokine and inflammatory cytokines in virus infected CEFs.Conclusions: These results demonstrate that baicalin could be a potential drug against MDV infection.

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“…We have previously demonstrated that the anti‐inflammatory effects of baicalin are mediated through the suppression of the NLRP3 inflammasome pathway in a lipopolysaccharide (LPS)‐challenged piglet mononuclear phagocyte model (Ye et al, ). Baicalin also suppresses the secretion of the inflammatory cytokines and HMGB1 via NF‐κB and NLRP3 signaling in Haemophilus parasuis (HPS)‐stimulated piglet cells (Fu, Liu, Chen, et al, ; Fu, Liu, Xu, et al, ; Fu et al, ).…”

Section: Pharmacokinetic Parameters Of Baicalin Following Single Intrmentioning

confidence: 99%

Pharmacokinetics of sodium baicalin following intravenous and intramuscular administration to piglets

Liu

Zhao

et al. 2019

Vet Pharm & Therapeutics

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The purpose of this study was to determine the pharmacokinetics of baicalin after intravenous and intramuscular administration of sodium baicalin at 50 mg/kg to piglets. Plasma baicalin levels were determined by high‐performance liquid chromatography. The plasma concentration–time data of baicalin for both administration routes were best described by two‐compartmental open model. The area under the plasma concentration–time curve and the elimination half‐lives were 77.47 ± 6.14 µg/ml × h and 1.73 ± 0.16 hr for intravenous and 64.85 ± 5.67 µg/ml × h and 2.42 ± 0.15 hr for intramuscular administration, respectively. The apparent volume of distribution and body clearance were 1.63 ± 0.23 L/kg and 2.74 ± 0.30 L h−1 kg−1 for intravenous and 0.51 ± 0.10 L/kg and 0.78 ± 0.08 L h−1 kg−1 for intramuscular routes, respectively. An intramuscular injection of sodium baicalin in piglets resulted in rapid and complete absorption, with a mean maximal plasma concentration of 77.28 ± 7.40 µg/ml at 0.17 hr and a high absolute bioavailability of 83.73 ± 5.53%.

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The anti-inflammatory effects of baicalin through suppression of NLRP3 inflammasome pathway in LPS-challenged piglet mononuclear phagocytes

Cited by 32 publications

References 32 publications

Baicalin Suppresses the Proliferation and Migration of Ox-LDL-VSMCs in Atherosclerosis through Upregulating miR-126-5p

Baicalin Suppresses the Proliferation and Migration of Ox-LDL-VSMCs in Atherosclerosis through Upregulating miR-126-5p

Antiviral effect of baicalin on Marek’s disease virus in CEF cells

Pharmacokinetics of sodium baicalin following intravenous and intramuscular administration to piglets

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