2018
DOI: 10.1080/0886022x.2018.1544565
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The anti-inflammatory effects of curcumin on renal ischemia-reperfusion injury in rats

Abstract: The present study aimed to explore the protective mechanism of curcumin-precondition in renal ischemia-reperfusion (I/R) injury. Thirty male SD rats were randomly equally divided into Sham, IRI, and Curcumin groups (n = 10). The model of IRI was induced by clamping the left renal artery for 45 min followed by 24 h reperfusion with the contralateral nephrectomy. ELISA was used to examine the expression of Cr, BUN, IL-8, TNF-α, and IL-6 in the serum; RT-PCR was used to detect the mRNA level of IL-8,TNF-α, and IL… Show more

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Cited by 32 publications
(39 citation statements)
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“…However, reports are inconsistent. One study noted that IR does not increase the concentrations of these cytokines (Zhu et al 2014), whereas other studies have reported increases in cytokine concentrations in proportion to the severity of injury (Shen et al 2018;Tang et al 2017;Zhang et al 2018;Zhang et al 2015). In this work, we did not observe significant increases in the concentrations of IL-1, IL-6, or TNF-.…”
Section: Discussioncontrasting
confidence: 59%
See 1 more Smart Citation
“…However, reports are inconsistent. One study noted that IR does not increase the concentrations of these cytokines (Zhu et al 2014), whereas other studies have reported increases in cytokine concentrations in proportion to the severity of injury (Shen et al 2018;Tang et al 2017;Zhang et al 2018;Zhang et al 2015). In this work, we did not observe significant increases in the concentrations of IL-1, IL-6, or TNF-.…”
Section: Discussioncontrasting
confidence: 59%
“…Several mechanisms are involved in the processes causing IR injury, such as ROS generation, redox imbalance, necrosis-apoptosis, and the inflammatory response (Dorweiler et al 2007). To ameliorate the effects of injury, various strategies have been tried including the use of antioxidants (Li et al 2014;Torres-González et al 2018;Yildiz et al 2015), anti-inflammatory compounds (Zhang et al 2018;Zhu et al 2014), and surgical strategies, such as IPC (Cai et al 2013;Cai et al 2008;Shen et al 2018) and RIPC (Albrecht et al 2013;Hausenloy & Yellon 2007;Kalakech et al 2013).…”
Section: Discussionmentioning
confidence: 99%
“…Curcumin regulates different proinflammatory and profibrotic cytokines and plays a crucial role in the mitigation of liver diseases and inrenal ischemia-reperfusion injury. Researchers demonstrated that the protective effect of curcumin inrenal ischemia-reperfusion injury is associated with suppressing NF-KB mediating inflammation; curcumin shows the inhibitory effect on HBV by activating the pathways suppressing the activation of NF- Κ b [24, 25]. In addition, after the activation of TGF- β 1 superfamily receptor, the biological signal is transmitted to the Smads protein in the middle and lower streams of the cytoplasm.…”
Section: Discussionmentioning
confidence: 99%
“…However, reports are inconsistent. One study noted that IR does not increase the concentrations of these cytokines ( Zhu et al, 2014 ), whereas other studies have reported increases in cytokine concentrations in proportion to the severity of injury ( Shen et al, 2018 ; Tang et al, 2017 ; Zhang et al, 2018 ; Zhang et al, 2015 ). In this work, we did not observe significant increases in the concentrations of IL-1β, IL-6, or TNF-α.…”
Section: Methodsmentioning
confidence: 99%
“…Several mechanisms are involved in the processes causing IR injury, such as ROS generation, redox imbalance, necrosis–apoptosis, and the inflammatory response ( Dorweiler et al, 2007 ). To ameliorate the effects of injury, various strategies have been tried including the use of antioxidants ( Li et al, 2014 ; Torres-González et al, 2018 ; Yildiz et al, 2015 ), anti-inflammatory compounds ( Zhang et al, 2018 ; Zhu et al, 2014 ), and surgical strategies, such as IPC ( Cai et al, 2013 ; Cai et al, 2008 ; Shen et al, 2018 ) and RIPC ( Albrecht et al, 2013 ; Hausenloy & Yellon, 2007 ; Kalakech et al, 2013 ).…”
Section: Methodsmentioning
confidence: 99%