The Anti-Inflammatory Effects of the Nutrition Bio-Shield (NBS) Supplement Intake on Adjuvant-Induced Rheumatoid Arthritis in Rat

NBS superfood: a promising adjunctive therapy in critically ill ICU patients with omicron variant of COVID-19

“…The striking congruence observed in the outcomes of the present clinical trial and the antecedent investigations conducted by Jalilian et al (Azizi Jalilian et al 2022 ) and Mosadegh (Mosadegh et al 2022a , b ) attests to the robust and consistent efficacy of NBS superfood as an adjunctive therapeutic agent amidst the backdrop of distinct SARS-CoV-2 variants. It is of paramount significance to underscore the temporal context in which these studies transpired.…”

“…These findings corroborate the anti-inflammatory properties of NBS observed in clinical trials on COVID-19 patients, underlining its broader therapeutic potential across inflammatory conditions. Further research is warranted to solidify its clinical value, but these collective results emphasize the promise of NBS as an adjunctive therapy for inflammatory diseases (Mosadegh et al 2022a , b ). These results underscore the significant impact of NBS superfood in mitigating inflammation and ameliorating disease severity among COVID-19 patients, in alignment with the findings of the present scientific research.…”

“…Furthermore, Mosadegh et al conducted a meticulously designed study investigating the impact of NBS superfood on a spectrum of laboratory biomarkers and disease severity in patients afflicted with COVID-19. The findings derived from their rigorously executed clinical trial unequivocally demonstrated a significant decrease in the mean serum levels of key parameters, including CRP, ESR, D-Dimer, lactate dehydrogenase (LDH), aspartate aminotransferase (SGOT), serum glutamic pyruvic aminotransferase (SGPT), alkaline phosphatase (ALP), WBC count, IL-6, and TNF-α, at the 14-day interval following intervention compared to baseline within the intervention group (Mosadegh et al 2022a , b ). Another investigation revealed that the NBS supplement, administered orally to rats with rheumatoid arthritis, significantly reduced serum levels of inflammatory markers such as ESR and CRP.…”

“…Conversely, their blood samples indicate a significant reduction in platelet and lymphocyte counts. It is widely acknowledged that the immune response to SARS-CoV-2, along with the secretion of inflammatory cytokines, plays a pivotal role in the progression of the infectious disease (Speakman et al 2021 ; Mosadegh et al 2022a , b ).…”

“…The Nutrition Bio-Shield (NBS Organik®, İstanbul, Turkey) powder is designated with an approved identification number (006633-14.11.2019) and is categorized as a natural herbal supplement known for its immune system-enhancing properties (Bayat et al 2014 ). NBS primarily derives from wheat germ and encompasses a diverse array of essential vitamins, including A, B1–B3, B5, B6, B9, C, D, K, and a complement of vital minerals such as potassium, manganese, magnesium, phosphorus, sulfur, boron, calcium, iron, zinc, copper, as well as essential fatty acids like omega-6 and omega-9, in addition to other macro and micro molecules (Azizi Jalilian et al 2022 ; Mosadegh et al 2022a , b ).…”