The anti-ischemic effects of CP-060S during pacing-induced ischemia in anesthetized dogs

Synthesis and antibacterial activity of some novel 2-Aroylimino-3-aryl-thiazolidin-4-ones

“…3 Thiazolidin-4-one derivatives are known to exhibit diverse bioactivities such as anticonvulsant, 4 antidiarrheal, 5 anti-platelet activating factor, 6 antihistaminic, 7 antimicrobial, 8 antidiabetic, 9 cycloxygenase inhibitory, 10 Ca 2+ channel blocker, 11 PAF antagonist, 12 cardioprotective, 13 anti ischemic, 14 anti cancer, 15 anti HIV, 16 non-peptide thrombin receptor antagonist 17 and tumor necrosis factor-α antagonist activities. 18 However, the 2-imino derivatives of thiazolidinones are explored to a lesser extent, in spite of the fact that the presence of imino function provides an additional point of structural diversity in a thiazolidinonebased pharmacophore (Figure 1).…”

Synthesis, Nematicidal and Antimicrobial Activity of 3-(5-3-Methyl-5-[(3-methyl-7-5-[2-(aryl)-4-oxo-1,3-thiazolan-3-yl]-1,3,4-thiadiazol-2-ylbenzo[<i>b</i>]furan-5-yl)methyl]benzo[<i>b</i>]furan-7-yl-1,3,4-thiadiazol-2-yl)-2-(aryl)-1,3-thiazolan-4-one

“…Thiazolidine-4-one derivatives are known to exhibit diverse bioactivities such as anti-convulsant, 17) antidiarrheal, 18) antiplatelet activating factor, [19][20][21] anti-histaminic, 22,23) antimicrobial, 24,25) anti-diabetic, 26) cyclooxygenase (COX) inhibitory, 27) Ca 2ϩ -channel blocker, 28) platelet activating factor (PAF) antagonist, 29) cardioprotective, 30) anti-ischemic, 31) anticancer, 32) tumour necrosis factor-a antagonist 33) and nematicidal activities. 34) Nematodes are tiny worms, some of them are plant parasites and can play an important role in the predisposition of the host plant to the invasion by secondary pathogens.…”

Synthesis, Nematicidal and Antifungal Properties of Hybrid Heterocyclics

“…[8][9][10] The thiazolidine-4-one ring also occurs in nature; thus actithiazic acid isolated from Streptomycis strains exhibits highly specific in vitro activity against mycobacteri-um Tuberculosis. 11 Thiazolidine-4-ones are known to exhibit diverse bioactivities, such as antiplatelet activating factor, 12 antihistaminic, 13 COX inhibitory, 14 Ca +2 channel blocking, 15 PAF antagonist, 16 cardioprotective, 17 anti-ischemic 18 and nematicidal activities. 19 Moreover, pyrazoles and their derivatives could be considered as possible antimicrobial agents.…”