The anti- Leishmaniasis activity of green synthesis silver oxide nanoparticles

Ismail, Hawraa H.; Hasoon, Salah Abdulla; Saheb, Entsar Jabbar

doi:10.36295/asro.2019.22044

Cited by 9 publications

(6 citation statements)

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“…[17][18][19] In their study, Ismail et al investigated the antileishmaniasis effect of silver oxide NPs, which resulted in a more favorable effect than the standard Leishmania drugs. 7 Accordingly, our findings are in line with those of the above-mentioned studies representing that silver NPs have even greater anti-parasitic activity compared to the Acanthamoeba choice drug.…”

Section: Discussionsupporting

confidence: 91%

“…In this regard, the antiparasitic effects of this NP on leishmania and malaria parasites have been tested, the findings of which are highly satisfactory. 7,8 However, it should be noted that the use of this material in high amounts is toxic to host cells and is not permitted, thus low concentrations of the NP should be tested and used to resolve this issue.…”

Section: Introductionmentioning

confidence: 99%

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Anti-parasitic Effects of Herbal Extract-Based Silver Nanoparticles on the Trophozoite and Cystic Forms of Acanthamoeba Protozoa

KarimiPourSaryazdi

Ghaffarifar

Tavakoli

et al. 2020

Int J Enteric Pathog

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Background: Acanthamoeba is a globally dispersed protozoan that can cause different clinical manifestations in infected individuals. Various drugs have been proposed against its drug-resistant forms. Objective: The present study examined silver nanoparticles (NPs) with a good anti-parasitic background. More precisely, the study focused on evaluating the anti-parasitic effect of silver nano-scale particles on protozoan trophozoite and cysts by microscopic counting and flow cytometry after exposure to different concentrations. Methods: To this end, MTT assay and IC50 were used to assess the macrophage toxicity and cysts/trophozoites, respectively. Results: Based on the results, 100 ppm silver NPs had better anti-parasitic effects than 80 ppm concentration and even the standard treatment of Acanthamoeba on both trophozoite and cystic phases. Macrophages toxicity at 100 ppm concentration was similar to the control group. Conclusion: In general, further studies should be conducted to confirm the present results given the significant effects of silver NPs against trophozoite and parasite cysts.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Anti-parasitic Effects of Herbal Extract-Based Silver Nanoparticles on the Trophozoite and Cystic Forms of Acanthamoeba Protozoa

KarimiPourSaryazdi

Ghaffarifar

Tavakoli

et al. 2020

Int J Enteric Pathog

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“…Nanoparticles synthesized using crude as well as various solvent-fractionated extracts of medically important plants are considered as efficient agents for the delivery of specific phytoconstituents into the cells. Keeping in view the effective antimicrobial activities of silver metal, silver/silver oxide NPs synthesized using a variety of medicinally important plant species, including Mentha arvensis L., Ficus benghalensis, Cuminum cyminum, Moringa oleifera, Silybum marianum, and Sechium edule, at a dosage of 10, 300, 0.5, 246, and 51.88 μg/ml tested against L. tropica, L. donovani, L. tropica, L. major, L. tropica, and Leishmania donovani, respectively (Baranwal et al, 2018;El-Khadragy et al, 2018;Hameed et al, 2019;Ismail et al, 2019;Bagirova et al, 2020;Javed et al, 2020). Gold and silver bimetallic NPs synthesized by using medically important plants have also been reported to be used for the prevention of this disease (Alti et al, 2020).…”

Section: Role Of Plant-based Nanoparticles In the Treatment Of Leishmaniasismentioning

confidence: 99%

“…Owing to the green and eco-friendly nature, cost effectiveness, less hazardous nature, and involvement of phytoconstituents for capping and stabilization, plant-based metal oxide nanoparticles (NPs) (silver, zinc, nickel, iron, etc.) have been in use to cure leishmanial infection (Ismail et al, 2019;Alti et al, 2020). The present review focuses on the use of plantbased natural products, the phytosynthesized NPs, to cure Leishmania.…”

Section: Introductionmentioning

confidence: 99%

Green Approach: ‘‘A Forwarding Step for Curing Leishmaniasis—A Neglected Tropical Disease’’

Sharma

Dhiman

Singh

et al. 2021

Front. Mol. Biosci.

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The present review focuses on a dreaded vector-mediated leishmaniasis, with the existing therapeutic approaches including a variety of drugs along with their limitations, the treatment with natural compounds, and different types of metal/metal oxide nanoparticles (NPs). As evidenced, various metallic NPs, comprising silver, silver oxide, gold, zinc oxide, titanium, lead oxide, etc., played a curative role to treat leishmaniasis, are also presented. Keeping in view the advance success of vaccines against the prevalent dreaded diseases in the past and the present scenario, efforts are also being made to develop vaccines based on these NP formulations.

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“…The green biosynthesized NPs were investigated in vitro at different concentrations (25,50,100,200, and 300 μg/ml) on L. donovani (DUAA/ IQ/2005/MRU15) promastigotes. The results indicated their marked inhibitory effects on the parasite growth when compared to both the standard anti-leishmanial drug (Pentostam) and the untreated control group [70] . Biogenic gold-silver bimetallic NPs (Au-Ag NPs) were synthesized through a single-step reduction process using aqueous leaf extracts of three plants: fenugreek, coriander, and soybean.…”

Section: Leishmania Sppmentioning

confidence: 97%

Potential applications of inorganic silver nanoparticles (AgNPs) in parasitic diseases

Gomaa

2022

Parasitologists United Journal

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Parasitic diseases are globally distributed, leading to considerable morbidity and mortality especially in low and middle-income countries. The current treatment strategies of parasitic infections face hard challenges due to emergence of drug resistance and intolerable side effects. Therefore, the development of novel, safe and effective anti-parasitic agents is urgently required. In this context, nanomaterials represent an efficient tool to overcome the barriers observed in several conventional therapeutics. Nanotechnology has efficiently provided tools enabling structural modifications in chemical compounds, empowering their highly desirable selectivity and specificity. Among them, metal nanoparticles (NPs) have been significantly utilized as an alternative therapeutic approach and/or efficient delivery system in a wide range of parasitic diseases. Due to its extraordinary range of bactericidal properties and therapeutic abilities, AgNPs have become a part of medical management of various diseases. Moreover, a number of plant species successfully employed in AgNPs green synthesis, are ecofriendly efficient alternatives to chemically synthesized NPs. The current review aims to shed light on AgNPs regarding their physiochemical properties, synthesis methods, and potential applications in diagnosis, treatment, and protection against parasitic infections. Concerning the last issue, their insecticidal activities paved the way for prevention of transmission of vector borne parasitic diseases.The present review is intended to shed light on one of the important members of inorganic metal NPs, the "AgNPs", regarding the physiochemical properties, the different methods of synthesis, the diagnostic applications in parasitic infections, the in vitro and in vivo anti-parasitic activities, the drug-delivery properties and finally the preventive potentials. Different medically important parasites, affected by AgNPs are listed in this review. Plants that were successfully used in green synthesis of AgNPs are also listed. Selected articles were gathered from Medline (PubMed), Scopus, Science Direct, Web of Science and Google Scholar using the keywords:

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The anti- Leishmaniasis activity of green synthesis silver oxide nanoparticles

Cited by 9 publications

References 0 publications

Anti-parasitic Effects of Herbal Extract-Based Silver Nanoparticles on the Trophozoite and Cystic Forms of Acanthamoeba Protozoa

Anti-parasitic Effects of Herbal Extract-Based Silver Nanoparticles on the Trophozoite and Cystic Forms of Acanthamoeba Protozoa

Green Approach: ‘‘A Forwarding Step for Curing Leishmaniasis—A Neglected Tropical Disease’’

Potential applications of inorganic silver nanoparticles (AgNPs) in parasitic diseases

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