2020
DOI: 10.1002/vjch.2019000133
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The anti‐microbial activities of secosteroids isolated from Physalis angulata

Abstract: In this article, four secosteroids, including physalin B (1), physalin D (2), physalin F (3), and physalin G (4) were isolated from the dichloromethane extract of P. angulata growing in Thai Binh, Vietnam by using various chromatographic methods. Their chemical structures were determined by analyses of 1D and 2D‐NMR spectral data as well as comparison with those published in the literature. Anti‐microbial assays showed that compounds 1‐3 exhibited anti‐microbial against a panel of clinically significant microo… Show more

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Cited by 5 publications
(4 citation statements)
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“…Their structures were established by various spectroscopic data and quantum chemical calculations. Twenty-three known withanolide derivatives ( 4 – 26 ), withaminimin ( 4 ), withagulatin A ( 5 ), physagulin A ( 6 ), physagulin B ( 7 ), physagulin J ( 8 ), physapubenolide ( 9 ), physagulide J ( 10 ), (20 S , 22 R )-15α-acetoxy-5α-chloro-6β,14β-dihydroxy-1-oxowitha-2,24-dienolide ( 11 ), physagulin F ( 12 ), physalin H ( 13 ), physalin B ( 14 ), isophysalin B ( 15 ), physalin D ( 16 ), physalin G ( 17 ), physalin E ( 18 ), physalin I ( 19 ), physalin F ( 20 ), 25-OH-physalin D ( 21 ), physaminin M ( 22 ), physaminin K ( 23 ), 5α,6β-dihydroxyphysalin R ( 24 ), aromaphysalin A ( 25 ), and aromaphysalin B ( 26 ), were assigned by comparing their NMR data with those in the literature.…”
Section: Resultsmentioning
confidence: 99%
“…Their structures were established by various spectroscopic data and quantum chemical calculations. Twenty-three known withanolide derivatives ( 4 – 26 ), withaminimin ( 4 ), withagulatin A ( 5 ), physagulin A ( 6 ), physagulin B ( 7 ), physagulin J ( 8 ), physapubenolide ( 9 ), physagulide J ( 10 ), (20 S , 22 R )-15α-acetoxy-5α-chloro-6β,14β-dihydroxy-1-oxowitha-2,24-dienolide ( 11 ), physagulin F ( 12 ), physalin H ( 13 ), physalin B ( 14 ), isophysalin B ( 15 ), physalin D ( 16 ), physalin G ( 17 ), physalin E ( 18 ), physalin I ( 19 ), physalin F ( 20 ), 25-OH-physalin D ( 21 ), physaminin M ( 22 ), physaminin K ( 23 ), 5α,6β-dihydroxyphysalin R ( 24 ), aromaphysalin A ( 25 ), and aromaphysalin B ( 26 ), were assigned by comparing their NMR data with those in the literature.…”
Section: Resultsmentioning
confidence: 99%
“…In addition, P. angulata L. leaf aqueous extract demonstrated activity against S. aureus ( 9 ) and an aqueous extract of the aerial parts was effective [minimum inhibitory concentration (MIC) 2.5 mg/ml)] against S. aureus and Listeria monocytogenes ( 10 ). In 2020, Cuong et al ( 11 ) studied four secosteroids, namely physalin B, D, F and G, obtained from a P. angulata dichloromethane extract. Physalin B was found to have antibacterial activity against S. aureus, Bacillus subtilis and Escherichia coli (E. coli) , with MIC values ranging from 32 to 128.…”
Section: Antibacterial Propertiesmentioning
confidence: 99%
“…P. angulata L. contains active ingredients that have medicinal properties. These active substances are: i) Physalin A in the roots, with antiparasitic properties ( 23 ), ii) physalin B in the whole plant, with anti-inflammatory, antiparasitic, antibacterial, anticancer and antifibrotic properties ( 10 , 16 , 17 , 27 , 29 , 31 , 37 , 43 ), iii) physalin D, F, G in the whole plant, with anti-inflammatory, antiparasitic and antibacterial properties ( 11 , 20 , 23 , 32 , 34 , 43 ), iv) physalin E in the whole plant, with anti-inflammatory and antiparasitic properties ( 23 ), v) physalin H in the root, with antiparasitic properties ( 20 , 31 ), vi) withangulatin A in the fruit, with antidiabetic properties ( 35 ) and vii) physangulatin A in the leaves and stems, with anti-inflammatory properties ( 35 ). The active substances in P. angulata L. are also presented in Table II and Fig.…”
Section: Chemical Components Of Physalis Angulata ...mentioning
confidence: 99%
“…Eight compounds were isolated and identified after repeated chromatography of this fraction using normal and reversed phase silica gel and Sephadex LH-20 as adsorbents (Figure 4). ese compounds were subsequently characterized as myricitrin (1) [47], afzelin (2) [48], apigenin (3) [49], taraxerol (4) [50], lupeol (5) [51], hispidulin (6) [52], physalin E (7) [53], and physalin D (8) [54], based on the detailed analysis (Table 2) of the NMR spectra (Figures S1-S16) and the published data. is is the first time that compounds 7 and 8 were isolated from the Ruellia genus.…”
Section: Isolation Of Potentially Anti-inflammatory Compoundsmentioning
confidence: 99%