The anti-osteoporotic effect of velvet antler polypeptides from Cervus elaphus Linnaeus in ovariectomized rats

Zhang, Lianzhu; Xin, Jile; Zhang, Xiping; Fu, Qin; Zhang, Yang; Zhou, Qiong

doi:10.1016/j.jep.2013.08.029

Cited by 41 publications

(29 citation statements)

References 19 publications

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“…In our study, VA-SDR has higher levels of alcoholic extract, while VA-Hay has higher levels of water extract, suggesting that VA-SDR has higher levels of polar and non-polar lipids and the water extracts contain mainly protein and some polar lipids. Many of the constituents within the two types of extract could exert anti-osteoporotic activity through different mechanisms (Li et al 2007;Zhang et al 2013). These data may also help to explain why in our study both types of VA effectively prevented the loss of vertebral and femoral bone strength and improved the trabecular bone microarchitecture induced by OVX in rats.…”

Section: Discussionmentioning

confidence: 53%

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Effects of different forages on the chemical compositions and antiosteoporotic activities of velvet antlers

Tseng

Chen

Lai

et al. 2015

Animal Science Journal

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For this study, we aimed to assess the dose-response antiosteoporotic effects of the middle section of velvet antlers (VAs) from sika deers (Cervus nippon) fed with different types of fodders. VAs prepared from farmed sika deers fed with feed mixtures containing sorghum distillery residue (VA-SDR) or without SDR (SDR replaced with hay, VA-Hay) were divided into upper (VAU), middle (VAM) and basal (VAB) sections. The chemical constituents of the middle sections obtained from each VA type were compared, and their antiosteoporotic activities were evaluated using rats with ovaries removed surgically (ovariectomy, OVX). The VA-Hay exhibited markedly increased iron and cysteine levels, whereas the VA-SDR exhibited markedly increased level of alcoholic extract and testosterone. Both VA-Hay- and VA-SDR-treated rats exhibited increased femur strength compared with the control group. However, VA-SDR exhibited greater bone-strengthening effects than did VA-Hay. The serum osteocalcin and estradiol levels were significantly moderated in the VA-Hay group alone. These results suggest that VA-SDR and VA-Hay prevent the loss of bone strength, and preserve trabecular architecture connectivity in an estrogen-deficient state. However, differences in the chemical compositions of different forages may be responsible for the varying antiosteoporotic mechanisms observed. Thus, the addition of SDR in deer forage may enhance antiosteoporosis activity in VAs, and confer considerable economic and ecological benefits.

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Section: Discussionmentioning

confidence: 53%

“…; Zhang et al . ). These data may also help to explain why in our study both types of VA effectively prevented the loss of vertebral and femoral bone strength and improved the trabecular bone microarchitecture induced by OVX in rats.…”

Section: Discussionmentioning

confidence: 97%

Effects of different forages on the chemical compositions and antiosteoporotic activities of velvet antlers

Tseng

Chen

Lai

et al. 2015

Animal Science Journal

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“…Antler polypeptide, which is isolated from antlers with molecular weight between 0.2 and 10 kDa, have many biological functions and activities [7]. Due to the small molecular weight, simple structures, low immunogenicity, and easily to be absorbed and utilized by cells, antler polypeptide have been widely used clinically to provide nutrition for the body [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

The separation of Antler Polypeptide and its effects on the proliferation and osteogenetic differentiation of Bone Marrow Mesenchymal Stem Cells

Wang

Sun

et al. 2020

Preprint

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The effects of antler polypeptide on rat bone marrow mesenchymal stem cells (BMSCs) were investigated. Antler polypeptide was separated from Colla Cornus Cervi by ultrafiltration into different samples according to molecular weight: A (molecular weight <800 Da), B (molecular weight 800-1500 Da) and C (molecular weight >1500 Da). The content of antler polypeptide in A, B and C solutions were quantified by high-performance liquid chromatography (HPLC). The effects of antler polypeptide at different concentrations on the proliferation, cell cycle, and osteogenesis of BMSCs were investigated. The highest cell proliferation rate (84.66%) was observed for antler polypeptide B at a concentration of 1.578 × 10 -2 g/mL. Antler polypeptide B significantly promoted the proliferation of BMSCs with a proliferation index of 38.68%, which was significantly higher than that of the other groups. Antler polypeptide B significantly enhanced the activity of alkaline phosphatase in BMSCs compared to that of blank group (P <0.001). Antler polypeptide B increased the BMP7 protein expression in BMSCs. Our data suggested that antler polypeptide may promote the proliferation and osteogenic differentiation of BMSCs.

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“…The anti‐fatigue effect is one of the main and vital pharmacological activities of VA . Water extract of VA can increase the swimming time in mice without affecting their natural growth .…”

Section: Introductionmentioning

confidence: 99%

“…The anti-fatigue effect is one of the main and vital pharmacological activities of VA. [19][20][21] Water extract of VA can increase the swimming time in mice without affecting their natural growth. [22] The swimming time in mice was prolonged by intragastric administration of the aqueous extract of VA for 30 days.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Anti‐Fatigue Effect and Simultaneous Determination of Eight Nucleosides in Different Parts of Velvet Antler in Red Deer and Sika Deer

Zhang

Guo

et al. 2020

Chemistry & Biodiversity

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Velvet antler (VA) is crucial and precious nourishment in China and some countries in Southeast Asia and has excellent anti‐fatigue effect. The incidence of fatigue syndrome has increased gradually. VA can be a potential source of anti‐fatigue products. Therefore, we investigated the anti‐fatigue activity of different sections (upper, middle, and basal section) of VA from different species (red deer and sika deer) via loading swimming test in mice. Furthermore, nucleosides are one kind of active components in VA which could considerably reduce fatigue in mice. In order to explore whether the nucleosides are correlated with anti‐fatigue effect, the contents of eight nucleosides (uracil, cytidine, hypoxanthine, xanthine, thymine, inosine, guanosine, and adenosine) were determined simultaneously using high‐performance liquid chromatography. The results indicated that the swimming time in mice was increased from basal to upper section, which was consistent with the change trend of the total contents of eight nucleosides of VA. Therefore, we speculated that the contents of nucleosides in VA may affect its anti‐fatigue effect. Furthermore, the contents of nucleosides were also used as a reference for evaluating the quality of different parts of VA obtained from red and sika deer.

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The anti-osteoporotic effect of velvet antler polypeptides from Cervus elaphus Linnaeus in ovariectomized rats

Cited by 41 publications

References 19 publications

Effects of different forages on the chemical compositions and antiosteoporotic activities of velvet antlers

Effects of different forages on the chemical compositions and antiosteoporotic activities of velvet antlers

The separation of Antler Polypeptide and its effects on the proliferation and osteogenetic differentiation of Bone Marrow Mesenchymal Stem Cells

Investigation of Anti‐Fatigue Effect and Simultaneous Determination of Eight Nucleosides in Different Parts of Velvet Antler in Red Deer and Sika Deer

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