Aqueous lubrication is commonly regarded as friendly to the environment. We review current knowledge of the behaviors and mechanisms of aqueous lubrication. Major methods for investigating aqueous lubrication are addressed. We describe studies on both friction and film formation performance of various water-based lubricants. Additionally, we discuss possible underlying mechanisms of aqueous lubrication. Attention is also drawn to continuing topics of investigation and some unsolved problems. [20][21][22], and aqueous lubrication [23][24][25]. Aqueous solutions are drawing attention because of their ecological advantages, fire-resistance, high thermal conductivity, nontoxicity, accessibility, biodegradability, environmental friendliness, and good solvency. However, water-based solutions have several disadvantages as lubricants, such as corrosiveness, vaporization and non-viscosity [26,27]. In the past several decades, aqueous fluids have been extensively used as lubricants in metal working processes, food processing, biological systems etc. Since petroleum will be exhausted within 50 years, aqueous fluids will have wide application in many industrial fields. Thus, research on aqueous fluids has become an important branch of tribology. Use of water-based lubrication in engineering can be traced back to about 2400 BC, when people used water as a lubricant in transporting statues in Egypt [28]. Meanwhile, water-based liquids have always been excellent lubricants in mammalian joints such as knees or hips, with friction coefficients μ< 0.002 [29,30]. Till now this ultra-low friction has not been well emulated in human-made aqueous systems. In contrast to oils and organic solvents, water has many unique properties due to the polarity of its molecules, which makes aqueous lubrication much more complicated than traditional lubrication with oils.Many studies have revealed both the characteristics and mechanisms of aqueous lubricants, with a wide variety of dimensions, conditions and application areas. In spite of the great efforts of both experimentalists and theorists, the study of aqueous lubrication still faces big challenges. As mentioned above, human-made systems seldom emulate natural lubrication well enough for practical use. Major efforts have been made to reduce the friction force of aqueous solutions between two solid surfaces and enhance the film formation ability at the same time. Nanotechnology has made much progress in revealing the underlying mechanisms and behaviors of materials at the nanometer-scale, especially the behaviors of atoms and molecules [31][32][33]. However, the mechanisms of aqueous lubrication are still not well known because of the diversity and complexity of aqueous solutions. This paper presents a general review of research on aqueous lubrication.