The anti-snake venom activities of the methanolic extract of the bulb of Crinum jagus (Amaryllidaceae)

Ode, O. J.; Asuzu, Isaac Uzoma

doi:10.1016/j.toxicon.2006.06.003

Cited by 43 publications

(33 citation statements)

References 8 publications

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“…The concept of the venom toxicity variation is well documented in the literature. For instance, Ode and Asuzu (2006) [35] used different venom concentrations (to that we used) of 10 mg/kg and 6 mg/kg of E. ocellatus and Naja n. nigricollis , respectively, to induce lethal effects. Moreover, from our previous work with E. ocellatus [36–38], for example, we have showed that venom variation occurred both locally and from region to region within the same species.…”

Section: Discussionmentioning

confidence: 99%

Antisnake Venom Activity ofHibiscus aethiopicusL. againstEchis ocellatusandNaja n. nigricollis

Hasson

Al-Jabri

Sallam

et al. 2010

Journal of Toxicology

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The objective of the study is to investigate whether the Hibiscus aethiopicus L. plant has neutralization activity against venoms of two clinically important snakes. The H. aethiopicus was dried and extracted with water. Different assays were performed to evaluate the plant's acute toxicity and its anti-snake venom activities. The results showed that H. aethiopicus extract alone had no effect on the viability of C2C12 muscle cells, but significantly (P < .05) protected muscle cells against the toxic effects of E. ocellatus venom at 55, 150, and 300 μg/mL. The maximum protective effect of the extract was exhibited at 75 μg/mL. The extract significantly (P < .001) inhibited the cytotoxic effects of E. ocellatus venom at 300 μg/mL. All rabbits (n = 10) and guinea pigs (n = 10) were alive after the two weeks of given the lethal dosage 16 g/Kg of the H. aethiopicus extract herbal solution. No abnormal behaviour was observed of both groups of animals. All guinea pigs (n = 3) treated with venoms alone (5 mg/kg) died. However, all guinea pigs (n = 21) treated with venom (5 mg/kg) and the extract (400 to 1000 mg/kg) survived. Guinea pigs (n = 3) treated with Naja n. nigricollis venom alone (2.5 mg/kg) and guinea pigs (n = 21) venom with the extract (400 to 1000 mg/kg) died. The H. aethiopicus completely (100%) blocked the haemorrhagic activity of E. ocellatus in the egg embryo at 3.3 mg/mL of extract. These findings suggest that H. aethiopicus may contain an endogenous inhibitor of venom-induced haemorrhage.

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Section: Discussionmentioning

confidence: 99%

Antisnake Venom Activity ofHibiscus aethiopicusL. againstEchis ocellatusandNaja n. nigricollis

Hasson

Al-Jabri

Sallam

et al. 2010

Journal of Toxicology

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“…Crinum jagus (Amaryllidaceae) is a plant widely used in Africa as antitumoral, antiviral, antiparasitary and immunostimulator. It is also used against mental trouble and snake bite [8]. According to traditional medicine practitioners in the Western Region of Cameroon, this plant is used as antidiabetic, antiobesity, antidiarrheoal remedy and also against poison.…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic and Antioxidant Activities of Crinum jagus Extracts on Induced Diabetes Rats MACAPOS 1

Mvongo

Mfopa

Kamgang

et al. 2016

IJPPE

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Abstract. The antioxidant and antidiabetic activities of aqueous and the hydroethanolic extracts of C. jagus were investigated on diabetic rats MACAPOS 1. Diabetes was induced on 6-8 weeks old wistar rats with high sugar diet (HSD) associated, one month after the beginning of the HSD, with dexamethasone (DXM) injection (25 µg/kg once every 2 days during 3 weeks). During 50 days, diabetic rats orally received Metformine (38 mg/kg bw), C. jagus hydroethanolic (75, 150 mg/kg bw) or aqueous (150 mg/kg bw) extracts. Treatment with extracts caused significant (P< 0.01) decrease in fasting glycemia, creatinemia, proteinuria, urine volume with concomitant increase in creatinuria, proteinemia, superoxide dismutase, catalase and thiol proteins. C. jagus extracts restored the imbalance of seric and urinary electrolytes, and significantly (P<0.01) increased peripheral sensibility to pain; the hydroethanolic extract was, in a dose dependant manner, more effective than aqueous extract and metformine. These results indicated that C. jagus extracts could possess antioxidant and antidiabetic activities on MACAPOS 1 diabetic rats, and could also improve renal and neurological diabetes damage. The results thus support the use of C. jagus in African folk medicine, mostly in diabetes mellitus treatment and likely its complications.

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“…Interestingly, numerous plants have been used as antidotes against various snake venoms in the folk medicinal systems of several countries (Mendes et al, 2007;Dal Belo et al, 2008;Ode et al, 2006). The veraciousness of the plants for the treatments of snakebite could be convinced by traditional healers and the folklore is far before the commercial anti-venoms were invented.…”

Section: Introductionmentioning

confidence: 99%

In vivo studies on detoxifying actions of aqueous bark extract of Prosopis cineraria against crude venom from Indian cobra (Naja naja)

Sivaraman

Rajesh

Elango

2013

Bangladesh J Pharmacol

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Detoxification effect of aqueous, methanol and petroleum ether extracts of medicinal plants such as Aristolochia bracteolata, Mucuna pruriens, Prosopis cineraria and Rauvolfia tetraphylla was systematically screened against lethality of crude venom of Naja naja using Swiss albino mice as animal models. We have herein demonstrated that aqueous bark extract of P. cineraria has substantial anti-venom potential vis-à-vis other extracts used in the present study. The aqueous extract at the dose of 14 mg/kg b.w. was able to almost completely neutralize the lethal activity of 3LD50 (1.1 mg/kg b.w.) of the cobra venom and the extract did not cause any types of adverse side-effects to the animal models. The investigation justifies not only the veraciousness of the extract used by traditional healers of Asian subcontinent as antidotes to snake venoms and also suggests that the aqueous extract should contain specific inhibitors to most principle toxic components of the crude venom. Article Info

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The anti-snake venom activities of the methanolic extract of the bulb of Crinum jagus (Amaryllidaceae)

Cited by 43 publications

References 8 publications

Antisnake Venom Activity ofHibiscus aethiopicusL. againstEchis ocellatusandNaja n. nigricollis

Antisnake Venom Activity ofHibiscus aethiopicusL. againstEchis ocellatusandNaja n. nigricollis

Antidiabetic and Antioxidant Activities of <i>Crinum jagus</i> Extracts on Induced Diabetes Rats MACAPOS 1

<i>In vivo</i> studies on detoxifying actions of aqueous bark extract of <i>Prosopis cineraria</i> against crude venom from Indian cobra (Naja naja)

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