The anti-tumor effect of ursolic acid on papillary thyroid carcinoma via suppressing Fibronectin-1

Xiao, Di; Ding, Xubei

doi:10.1080/09168451.2020.1813543

Cited by 7 publications

(6 citation statements)

References 35 publications

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“…Sponziello et al con rmed that the proliferation, adhesion, migration, as well as invasion of PTC cells were signi cantly suppressed after the silencing of FN1 [25]. Ursolic acid inhibited PTC cell viability, proliferation, and EMT but promoted apoptosis via suppressing FN1, thus exert antitumor effects in vivo [26]. As a calcium-dependent phospholipid-binding protein, ANXA1(Annexin A1) presents a molecular weight of 37 kDa and is involved in cell growth, differentiation, and apoptosis [27,28].…”

Section: Discussionmentioning

confidence: 99%

Label-Free Proteome Profiling for Lymphatic Metastasis in Papillary Thyroid Carcinoma

Chen

Jiang

et al. 2022

Preprint

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As the most common malignant tumor, the incidence of papillary thyroid carcinoma (PTC) has been significantly increased over the past few years. Approximately 30%-90% of patients with PTC present with cervical lymph node metastasis (LNM) at the time of initial diagnosis or follow-up, which has a serious impact on survival and prognosis. Six PTC N0 samples and six PTC N1b samples were collected. Proteins from the samples were analyzed by label-free quantitative proteomics. The bioinformatics of differentially expressed proteins (DEPs) was annotated with bioinformatic tools. The protein expression levels of the hub genes were verified using the HPA databases. Finally, we used the GEPIA database to perform survival analysis for the hub genes. A total of 1407 proteins were quantified under highly stringent criteria with fold change ≥ 2.0 and P < 0.05, and 95 DEPs were significantly changed between groups. Identified from the Cytoscape, the top 10 hub genes included FN1、CFL1、LGALS3、ANXA1、TIMP1、TPI1、MAPK1、HSPA9、ACTR2 and S100A11. We determined the hub genes expression in thyroid normal and cancer tissues using the HPA database. The expression of FN1 and ANXA1were closely related to disease free survival (DFS) and overall survival (OS) prognosis in PTC patients based on GEPIA database. These results revealed the pathways and mechanisms of LNM in PTC, thus providing a new perspective for the study of PTC with LNM. Together, these hub genes may have some clinical value in diagnosing PTC patients with LNM.

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Section: Discussionmentioning

confidence: 99%

Label-Free Proteome Profiling for Lymphatic Metastasis in Papillary Thyroid Carcinoma

Chen

Jiang

et al. 2022

Preprint

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“…A number of other studies have demonstrated that ursolic acid has anti-cancer effects against various cancer types including esophageal cancer [108], pancreatic cancer [109], and colorectal cancer [110] via a number of different mechanisms, including the induction of ROS-mediated autophagy [108] and ER stressmediated RAGE inhibition, promoting apoptosis and autophagy [109], and up-regulation of ROS and caspase-3, -8, and -9, thereby inducing apoptosis [92]. Further anti-tumor effects of ursolic acid have been observed in papillary thyroid carcinoma cells, mediated via enhancement of fibronectin-1 expression and subsequent induction of apoptosis [111].…”

Section: Ursolic Acidmentioning

confidence: 99%

“…Ursolic acid Apple peels ↑ sFRP4, sp1, Caveolin-1, Bax, p21, p53, Cyclin B1, Caspase-3, Caspase-8, Caspase-9, fibronectin-1, E-Cad, and LC3-II Gliolastoma [104], breast [100,101], intestinal [102], lung [103], colorectal [105], esophageal [106], and pancreatic [107] [111], breast [112,113], prostate [115], ovarian [114], colorectal [116,117], lung [118], gastric [56], and endometrial [119] cancer ↓ MMP-2, FAK, CDK1, PSA, TMPRSS2, TMEPA1, PI3K, Akt, Bcl-2, TS, RhoA, Rac1, JAK/STAT3, MAPK, and NFκB Quercetin Apple, chili pepper, blueberry, cherry, cranberry, black tea, and red wine ↑ p53 Liver [120,121], prostate [122,123], colon [123], leukemia [123], lymphoma [123], breast [123,124], pancreatic [125], lung [126],…”

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confidence: 99%

The Anti-Cancer Effects of Red-Pigmented Foods: Biomarker Modulation and Mechanisms Underlying Cancer Progression

2022

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Cancer is one the most malignant diseases that is a leading cause of death worldwide. Vegetables and fruits contain beneficial nutrients such as vitamins, minerals, folates, dietary fibers, and various natural bioactive compounds. These can prevent the pathological processes of many cancers and reduce cancer related mortality. Specifically, the anti-cancer effect of vegetables and fruits is largely attributable to the natural bioactive compounds present within them. A lot of bioactive compounds have very specific colors with pigments and the action of them in the human body varies by their color. Red-pigmented foods, such as apples, oranges, tomatoes, cherries, grapes, berries, and red wine, have been widely reported to elicit beneficial effects and have been investigated for their anti-tumor, anti-inflammatory, and antioxidative properties, as well as anti-cancer effect. Most of the anti-cancer effects of bioactive compounds in red-pigmented foods arise from the suppression of cancer cell invasion and metastasis, as well as the induction of apoptosis and cell cycle arrest. In this review, we assessed publications from the last 10 years and identified 10 bioactive compounds commonly studied in red-pigmented foods: lycopene, anthocyanin, β-carotene, pectin, betaine, rutin, ursolic acid, kaempferol, quercetin, and myricetin. We focused on the mechanisms and targets underlying the anti-cancer effect of the compounds and provided rationale for further investigation of the compounds to develop more potent anti-cancer treatment methods.

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“…Ursolic acid (3‐hydroxy‐12‐ursen‐28‐oic acid, UA, Figure 1) belongs to pentacyclic triterpenoids that mainly exist in plants such as the whole grass of Prunella vulgaris, and Ilex. It exhibits wide range of pharmacological activities, including anti‐oxidation (Wang et al, 2018), anti‐bacterial (Qian et al, 2020), anti‐ulcer (Liu et al, 2016), anti‐inflammatory (Wang et al, 2018), anti‐tumor (Cao et al, 2020) anti leukemia (da Silva et al, 2021), lowering blood glucose (Alkreathy & Ahmad, 2020), as well as obvious stability and cooling effects on the central nervous system (Colla et al, 2021), and liver protection (Ma et al, 2021). In recent years, it has attracted much attention due to its strong pharmacological activity, slight side effects, and a vast range of sources.…”

Section: Introductionmentioning

confidence: 99%

Recent progress in the development of ursolic acid derivatives as anti‐diabetes and anti‐cardiovascular agents

Dai,

Sun,

Tan

et al. 2023

Chem Biol Drug Des

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Ursolic acid (UA) is a pentacyclic triterpenoid, which exhibits many biological activities, particularly in anti‐cardiovascular and anti‐diabetes. The further application of UA is greatly limited due to its low bioavailability and poor water solubility. Up to date, various UA derivatives have been designed to overcome these shortcomings. In this paper, the authors reviewed the development of UA derivatives as the anti‐diabetes anti‐cardiovascular reagents.

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The anti-tumor effect of ursolic acid on papillary thyroid carcinoma via suppressing Fibronectin-1

Cited by 7 publications

References 35 publications

Label-Free Proteome Profiling for Lymphatic Metastasis in Papillary Thyroid Carcinoma

Label-Free Proteome Profiling for Lymphatic Metastasis in Papillary Thyroid Carcinoma

The Anti-Cancer Effects of Red-Pigmented Foods: Biomarker Modulation and Mechanisms Underlying Cancer Progression

Recent progress in the development of ursolic acid derivatives as anti‐diabetes and anti‐cardiovascular agents

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