The anti-tumor effects of alkaloids from the seeds of Strychnos nux-vomica on HepG2 cells and its possible mechanism

Deng, Xukun; Wu, Yin; Li, Weidong; Yin, Fan; Lu, Xiaoyu; Zhang, Xiaochun; Hua, Zichun; Cai, Baochang

doi:10.1016/j.jep.2005.12.021

Cited by 126 publications

(50 citation statements)

References 14 publications

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“…Studies involving in vitro culture of hepatoma carcinoma cells have shown that strychinin could inhibit the proliferation of HepG2 and SMMC-7721 cells. [9][10][11][12] Unfortunately, the potential use of brucine is severely limited due to high incidence of side effects. Because it is strongly fat-soluble and easily distributed in the central nervous system (CNS) in the brain and other organs, it exerts severe CNS toxicity.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo evaluation of novel NGR-modified liposomes containing brucine

Li¹

2017

IJN

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In this study, a novel NGR (Asn-Gly-Arg) peptide-modified liposomal brucine was prepared by using spray-drying method. The surface morphology of the liposomes, encapsulation efficiency and particle size were investigated. The data showed that the addition of NGR did not produce any significant influence on brucine liposomes in terms of particle size or zeta potential. In addition, after 3 months of storage, no dramatic change such as visible aggregation, drug content changes or precipitation in the appearance of NGR-brucine liposomes occurred. The in vitro release results indicated that the release of brucine from NGR liposomes was similar to that of liposomes, demonstrating that the NGR modification did not affect brucine release. The in vitro drug-release kinetic model of NGR-brucine liposomes fitted well with the Weibull’s equation. In vivo, NGR-brucine liposomes could significantly extend the bioavailability of brucine; however, there was no significant difference observed in the pharmacokinetic parameters between liposomes and NGR liposomes after intravenous administration. Antitumor activity results showed that NGR-modified liposomes exhibited less toxicity and much higher efficacy in HepG2-bearing mice compared with non-modified liposomes. The enhanced antitumor activity might have occurred because brucine was specifically recognized by NGR receptor on the surface of tumor cells, which enhanced the intracellular uptake of drugs.

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Section: Introductionmentioning

confidence: 99%

In vitro and in vivo evaluation of novel NGR-modified liposomes containing brucine

Li¹

2017

IJN

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“…Ltd., followed by Merck, India. The media like, agar, cholesterol, hypochlorite solution, proteose peptone and yeast extract were procured from Hi-Media, (Mumbai), India (Deng et al, 2006;Zakaria et al, 2011).…”

Section: Chemicalsmentioning

confidence: 99%

Evaluation of Validated Herbal Medicine Formulation for AntiProliferative and Apoptotic Activities Used In the Tribal Medicine System

Murthy¹,

Chandrasekhar²,

Ravishankar³

et al. 2017

IOSR

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“…In addition, brucine caused apoptosis of HepG2 cells may be due to the participation of caspase 3 and cyclooxygenase 2. [18] Further observations highlighted that brucine producing distinctive characteristics of apoptotic programmed cell death including cell shrinkage, nucleus condensation formation of the apoptotic body, and membrane blebbing. Furthermore, the flow-cytometry analysis reported that phosphatidylserine externalization and formation of subdipolid DNA caused cells apoptosis.…”

Section: Phytochemical Constituents Of S Nux-vomicamentioning

confidence: 99%

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Vyas

2016

IJGP

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Herbs used in traditional medicine have provided a nidus for the discovery of various new molecules having therapeutic viability. With the advent of various diseases, the science has also armed itself to combat the everevolving family of diseases with the help of these new molecules. Cancer is one such area which has limited scope for management through conventional therapy. Recent research advances in herbal medicine have opened new horizons in the medicinal chemistry sector. Nux-vomica, a medicinal plant, has a long history of use in traditional medicine. Recently, this plant has been extensively researched on for its anti-cancer potential. By the virtue of the alkaloids, viz., strychnine and brucine in nux-vomica, it has shown promising results as an anticancer agent. The present review paper will comprehend such research including their possible mechanism of action.

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The anti-tumor effects of alkaloids from the seeds of Strychnos nux-vomica on HepG2 cells and its possible mechanism

Cited by 126 publications

References 14 publications

In vitro and in vivo evaluation of novel NGR-modified liposomes containing brucine

In vitro and in vivo evaluation of novel NGR-modified liposomes containing brucine

Evaluation of Validated Herbal Medicine Formulation for AntiProliferative and Apoptotic Activities Used In the Tribal Medicine System

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