The Anti-tumor Effects of Vitamin D in Other Cancers

Trump, Donald L.; Johnson, Candace S.

doi:10.1016/b978-0-12-381978-9.10090-3

Cited by 2 publications

(2 citation statements)

References 144 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vitamin D 3 , directly or indirectly, regulates expression of genes that control cell cycle, proliferation, differentiation, apoptosis, angiogenesis and carcinogenesis in a wide range of tissues and organs . To analyze the effect of dietary or systemic manipulation of vitamin D 3 levels in mice with A431 tumors, we examined markers of differentiation (E‐ cadherin) and proliferation (Ki67) using immunohistochemistry.…”

Section: Resultsmentioning

confidence: 57%

Combination of Oral Vitamin D₃ with Photodynamic Therapy Enhances Tumor Cell Death in a Murine Model of Cutaneous Squamous Cell Carcinoma

Anand

Rollakanti

Horst

et al. 2014

Photochem & Photobiology

View full text Add to dashboard Cite

Photodynamic therapy (PDT), in which 5-ALA (a precursor for protoporphyrin IX, PpIX) is administered prior to exposure to light, is a nonscarring treatment for skin cancers. However, for deep tumors, ALA-PDT is not always effective due to inadequate production of PpIX. We previously developed and reported a combination approach in which the active form of vitamin D3 (calcitriol) is given systemically prior to PDT to improve PpIX accumulation and to enhance PDT-induced tumor cell death; calcitriol, however, poses a risk of hypercalcemia. Here, we tested a possible strategy to circumvent the problem of hypercalcemia by substituting natural dietary vitamin D3 (cholecalciferol; D3) for calcitriol. Oral D3 supplementation (10 days of a 10-fold elevated D3 diet) enhanced PpIX levels 3- to 4-fold, and PDT-mediated cell death 20-fold, in subcutaneous A431 tumors. PpIX levels and cell viability in normal tissues were not affected. Hydroxylated metabolic forms of D3 were only modestly elevated in serum, indicating minimal hypercalcemic risk. These results show that brief oral administration of cholecalciferol can serve as a safe neoadjuvant to ALA-PDT. We suggest a clinical study, using oral vitamin D3 prior to PDT, should be considered to evaluate this promising new approach to treating human skin cancer.

show abstract

Section: Resultsmentioning

confidence: 57%

Combination of Oral Vitamin D₃ with Photodynamic Therapy Enhances Tumor Cell Death in a Murine Model of Cutaneous Squamous Cell Carcinoma

Anand

Rollakanti

Horst

et al. 2014

Photochem & Photobiology

View full text Add to dashboard Cite

show abstract

“…Anti-tumor effects of vitamin D in animal models for cancers are well-documented [ 45 ]. Detailed discussions about vitamin D actions in cancers of the breast [ 46 ], prostate [ 47 ], colorectum [ 48 ], hematological malignancies [ 49 ] and other cancers [ 50 ], have established the plausibility of a causal role between vitamin D and cancer. However, as emphasized by Jacobs et al [ 51 ], it has been challenging to reconcile the results from laboratory studies, demonstrating the biological mechanisms of the active hormone form of vitamin D (1,25(OH) 2 D), and the observational studies, using levels of circulating 25-OHD.…”

Section: Discussionmentioning

confidence: 99%

The Inverse Relationship between 25-Hydroxyvitamin D and Cancer Survival: Discussion of Causation

Robsahm

Schwartz

Tretli

2013

Cancers

View full text Add to dashboard Cite

Cancer mortality rates vary inversely with geographic latitude and solar ultraviolet-B doses. This relationship may be due to an inhibitory role of vitamin D on cancer development. The relationship between vitamin D and cancer appears to be stronger for studies of cancer mortality than incidence. Because cancer mortality reflects both cancer incidence and survival, the difference may be due to effects of vitamin D on cancer survival. Here we review analytic epidemiologic studies investigating the relation between vitamin D, measured by circulating levels of 25-hydroxyvitamin D (25-OHD), and cancer survival. A relationship between low 25-OHD levels and poor survival is shown by most of the reviewed studies. This relationship is likely to be causal when viewed in light of most criteria for assessing causality (temporality, strength, exposure-response, biological plausibility and consistency). A serum level of 25-OHD around 50 nmol/L appears to be a threshold level. Conversely, there are several mechanisms whereby cancer could lower serum levels of 25-OHD. The severity of disease at the time of diagnosis and time of serum sampling are key factors to clarify the temporal aspect of these relationships. Evidence that vitamin D supplementation could retard the disease process or prolong survival time would be key evidence, but is difficult to generate. However, recent clinical trial results in prostate cancer support a role for vitamin D in this regard.

show abstract

The Anti-tumor Effects of Vitamin D in Other Cancers

Cited by 2 publications

References 144 publications

Combination of Oral Vitamin D₃ with Photodynamic Therapy Enhances Tumor Cell Death in a Murine Model of Cutaneous Squamous Cell Carcinoma

Combination of Oral Vitamin D₃ with Photodynamic Therapy Enhances Tumor Cell Death in a Murine Model of Cutaneous Squamous Cell Carcinoma

The Inverse Relationship between 25-Hydroxyvitamin D and Cancer Survival: Discussion of Causation

Contact Info

Product

Resources

About

The Anti-tumor Effects of Vitamin D in Other Cancers

Cited by 2 publications

References 144 publications

Combination of Oral Vitamin D3 with Photodynamic Therapy Enhances Tumor Cell Death in a Murine Model of Cutaneous Squamous Cell Carcinoma

Combination of Oral Vitamin D3 with Photodynamic Therapy Enhances Tumor Cell Death in a Murine Model of Cutaneous Squamous Cell Carcinoma

The Inverse Relationship between 25-Hydroxyvitamin D and Cancer Survival: Discussion of Causation

Contact Info

Product

Resources

About

Combination of Oral Vitamin D₃ with Photodynamic Therapy Enhances Tumor Cell Death in a Murine Model of Cutaneous Squamous Cell Carcinoma

Combination of Oral Vitamin D₃ with Photodynamic Therapy Enhances Tumor Cell Death in a Murine Model of Cutaneous Squamous Cell Carcinoma