The antibacterial activity of Libanstin from Ilex paraguariensis (Yerba Mate)

El-Sawalhi, Sabah; Fayad, Elie; Porras, Gina; Fayad, Antoine Abou; Abdel-Massih, Roula M.

doi:10.1016/j.fitote.2021.104962

Cited by 6 publications

(8 citation statements)

References 26 publications

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“…However, previous studies have found a positive effect of YM infusion on BMD in postmenopausal women and experimental animals. [ 14 , 15 ]…”

Section: Discussionmentioning

confidence: 99%

“…[9] Additional studies showed that YM has anti-obesity, anti-inflammatory, antibacterial and immunomodulatory effects. [10][11][12][13][14] A positive effect of YM has been previously observed on bone, both in experimental animals and in postmenopausal women. A higher femoral neck and lumbar bone mineral density (BMD) was found in postmenopausal women who drank more than 1 liter of YM per day for at least 5 years compared to controls who did not drink YM infusion.…”

Section: Introductionmentioning

confidence: 90%

“…[ 9 ] Additional studies showed that YM has anti-obesity, anti-inflammatory, antibacterial and immunomodulatory effects. [ 10 – 14 ]…”

Section: Introductionmentioning

confidence: 99%

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Increased Osteoblastic and Osteocytic in Vitro Cell Viability by Yerba Mate (Ilex paraguariensis)

Villarreal,

Sanz,

Fagalde

et al. 2024

J Bone Metab

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Background: Yerba mate (YM, <i>Ilex paraguariensis</i>) consumption beneficially affects the bones. However, whether YM components exert their effect on bone cells directly remains elusive.Methods: We evaluated how main YM components affect osteoblastic (MC3T3-E1) and osteocytic (MLO-Y4) cells <i>in vitro</i> when administered separately or in an aqueous extract. MC3T3-E1 and MLO-Y4 cells were exposed to three different experimental conditions: (1) Caffeine, chlorogenic acid, and their combinations; (2) Caffeine, rutin, and their combinations; (3) Aqueous YM extract.Results: All polyphenol and caffeine concentrations as well as that of their tested combinations significantly increased MC3T3-E1 cell viability from 16.6% to 34.8% compared to the control. In MLO-Y4 cells, the lowest rutin and the two highest caffeine concentrations significantly increased cell viability by 11.9, 14.9, and 13.7%, respectively. While rutin and caffeine combinations tended to increase MLO-Y4 cell viability, different chlorogenic acid and caffeine combinations did not affect it. Finally, the aqueous YM extract significantly increased MLO-Y4, MC3T3-E1, and differentiated MC3T3-E1 cell viability compared to the control without treatment.Conclusions: YM components (rutin, chlorogenic acid, and caffeine) positively affected bone cells, mainly pre-osteoblast cells. Moreover, the aqueous YM extract significantly increased MLO-Y4, MC3T3-E1, and differentiated MC3T3-E1 cell viabilities indicating an additional relevant nutritional property of YM infusion. Further studies would be required to elucidate the underlying effector mechanism of YM on the bones and its relationship with previously described in vivo positive effects.

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“…However, previous studies have found a positive effect of YM infusion on BMD in postmenopausal women and experimental animals. [ 14 , 15 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

See 1 more Smart Citation

Increased Osteoblastic and Osteocytic in Vitro Cell Viability by Yerba Mate (Ilex paraguariensis)

Villarreal,

Sanz,

Fagalde

et al. 2024

J Bone Metab

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“…The antibacterial activity of the diet pill's metabolites was evaluated through an in vitro digestion method that is a simulation of in vivo digestion. This procedure was performed as described by Sabah et al (2021) [21] with modifications from Ryan et al (2010) [22]. Briefly, the diet pill powder was first treated with α-amylase to mimic oral digestion, followed by treatment with porcine pepsin adjusted to pH 2 for gastric digestion.…”

Section: Diet Pill In Vitro Digestion Proceduresmentioning

confidence: 99%

Antibacterial effect of a diet pill supplement on the human intestinal bacteria

Haddam

Othman²,

Dandachi³

et al. 2023

J Infect Dev Ctries

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Introduction: Many people worldwide attempt to lose weight or adopt strategies to control it. Some have resorted to the consumption of commercialized diet pills to achieve this goal. Multiple brands exist without clearly indicating their mechanism of action or adverse effects on human health. This study aims to determine the antibacterial effect of commercial diet pills on members of the intestinal microbiota. Methodology: Commercialized diet pills were bought from a pharmacy in the North of Lebanon. Broth microdilution test was performed to determine the Minimum Inhibitory Concentrations (MICs) of the aqueous suspension against forty-two isolates distributed into four Enterobacterales species. MIC of the digested form was determined against six different strains. GC-MS analysis was performed to elucidate the components of the diet pill compared to the manufacturer's list. Results: Broth microdilution results revealed that MICs of the diet pill aqueous suspension ranged from 3.9x103-9.76x102 µg/mL for Escherichia coli, Enterobacter spp., and Proteus spp. For Klebsiella species, MIC of carbapenem-resistant isolates reached 1.95x103 µg/mL. The digested form had a significantly lower antibacterial effect compared to the aqueous suspension. GC-MS analysis results corresponded with the list of ingredients provided by the manufacturer. Conclusions: The results showed significant antibacterial activity of a commercial diet pill on different members of the human intestinal microbiota regardless of their resistance profile. Further work is needed to elucidate the antibacterial effect of the digested components to accurately understand their effect on the intestinal microflora and thus on human health.

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“…De las hojas y ramas, secas y molidas de esta aquifoliácea se prepara el mate, una infusión originaria de su zona de crecimiento natural (la selva paranaense) y común en la gastronomía de Paraguay, el Sur de Brasil, Argentina, sur y este de Bolivia, Uruguay y ciertas regiones del sur de Chile, por lo que es ampliamente cultivada en Argentina, Brasil y Paraguay. Popularmente se le asocian propiedades estimulantes asociada a la presencia de alcaloides como la cafeína (Mesquita et al, 2021) y se han descrito potencialidades antimicrobianas (El-Sawalhi et al, 2021).…”

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Desarrollo de aditivos antimicrobianos basados en nanopartículas metálicas obtenidas por síntesis verde para su aplicación en recubrimientos

Roque

Bellotti

Viera

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La preocupación creciente por el control de la colonización y crecimiento de hongos y bacterias en los interiores edilicios ha impulsado distintas líneas investigativas que comprenden el desarrollo de nuevas pinturas y recubrimientos con propiedades antimicrobianas que eviten el asentamiento de los microorganismos. Estas formulaciones contienen uno o más aditivos antimicrobianos llamados biocidas. Entre los productos investigados se destacan las nanopartículas de ciertos materiales metálicos (plata, cobre, selenio y oro) que han mostrado algún grado de bioactividad. Las nanopartículas se caracterizan por contar con propiedades dependientes del tamaño y la forma, a su vez, éstas son afectadas por el método y las condiciones de síntesis. Existe un creciente interés en desarrollar procesos de obtención de nanopartículas que sean amigables con el ambiente, es decir que eviten el uso de productos químicos cuestionados desde el punto de vista de su toxicidad. Esta tendencia enmarcada en la denominada química verde tiene como objetivos principales reducir los desechos, minimizar el uso de productos no seguros y beneficiar el uso de solventes y reactivos amigables con el ambiente. La síntesis verde de nanopartículas basada en el uso de extractos vegetales acuosos resulta promisoria por ser accesible, efectiva, segura, de bajo costo, no contaminante y por ofrecer vastas posibilidades. El objetivo de esta investigación fue desarrollar nuevos aditivos antimicrobianos de base nanotecnológica obtenidos por síntesis verde, aplicables en forma eficiente en la formulación de pinturas antimicrobianas que prevengan el biodeterioro. Para lograr este objetivo se trabajó en primer lugar en la obtención, caracterización y selección de las nanopartículas con mayor actividad tanto antibacteriana como antifúngica. En una siguiente etapa, se formularon y prepararon pinturas con los aditivos antimicrobianos desarrollados reemplazando los biocidas tradicionales que se usan en las pinturas comerciales fuertemente cuestionados desde el punto de vista de la salud y el impacto ambiental.

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The antibacterial activity of Libanstin from Ilex paraguariensis (Yerba Mate)

Cited by 6 publications

References 26 publications

Increased Osteoblastic and Osteocytic in Vitro Cell Viability by Yerba Mate (Ilex paraguariensis)

Increased Osteoblastic and Osteocytic in Vitro Cell Viability by Yerba Mate (Ilex paraguariensis)

Antibacterial effect of a diet pill supplement on the human intestinal bacteria

Desarrollo de aditivos antimicrobianos basados en nanopartículas metálicas obtenidas por síntesis verde para su aplicación en recubrimientos

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