The antibacterial effect of 2-octyl cyanoacrylate (Dermabond®) skin adhesive

Rushbrook, Jeremy; White, Grace; Kidger, Lizi; Marsh, Philip; Taggart, T

doi:10.1177/1757177414551562

Cited by 75 publications

(37 citation statements)

References 27 publications

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“…In fact, cyanoacrylate adhesives have been considered by several schools with antibacterial properties, but were attributed initially to the formation of a film that protect the cells, and in this sense as a barrier for the access of bacteria to the wound . However, Rushbrook et al have demonstrated recently that this is not the exclusive reason and in a deep analysis of the antibacterial effect of 2‐octyl cyanoacrylate skin adhesive (Dermabond) they have found a clear intrinsic bactericidal effect against Gram‐positive bacteria. Therefore, we can consider that the application of cyanoacrylic adhesives provides a considerable antibacterial effect independently of the nature of the corresponding compound.…”

Section: Resultsmentioning

confidence: 99%

Structural Analysis and Application of n‐Alkyl Cyanoacrylate Surgical Adhesives to the Fixation of Meshes for Hernia Repair

Fernández-Gutiérrez

Rodriguez-Mancheño

Pérez-Köhler

et al. 2016

Macromolecular Bioscience

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The article deals with a comparative analysis of the parameters of the polymerization in physiological conditions of three commercially available alkyl cyanoacrylates, n-butyl cyanoacrylate (GLUBRAN 2), n-hexyl cyanoacrylate (IFABOND), and n-octyl cyanoacrylate (EVOBOND), the cell behavior of the corresponding polymers and the application of these adhesives in the fixation of surgical polypropylene meshes for hernia repair in an animal model of rabbits. The results obtained demonstrate that the curing process depends on the nature of the alkyl residue of the ester group of cyanoacrylate molecules, being the heat of polymerization lower for the octyl derivative in comparison with the hexyl and butyl, and reaching a maximum temperature of 35 °C after a time of mixing with physiological fluids of 60-70 s. The cell behavior demonstrates that the three systems do not present toxicity for fibroblasts and low adhesion of cells, which is a positive result for application as tissue adhesives, especially for the fixation of abdominal polypropylene meshes for hernia repair. The animal experimentation indicates the excellent tolerance of the meshes fixed with the cyanoacrylic adhesives, during at least a period of 90 d, and guarantees a good adhesion for the application of hernia repair meshes.

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Section: Resultsmentioning

confidence: 99%

Structural Analysis and Application of n‐Alkyl Cyanoacrylate Surgical Adhesives to the Fixation of Meshes for Hernia Repair

Fernández-Gutiérrez

Rodriguez-Mancheño

Pérez-Köhler

et al. 2016

Macromolecular Bioscience

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“…At least one study has shown 2‐octyl cyanoacrylate skin adhesive to have antimicrobial properties against gram‐positive bacteria, and multiple studies have shown lower rates of surgical site infection with superficial cyanoacrylate closures than with traditional closure techniques such as staples and sutures . Cyanoacrylate tissue adhesives should not be used in tension‐bearing wounds, hairy areas, crush wounds, areas of high moisture, or wounds at high risk of infection .…”

Section: Discussionmentioning

confidence: 99%

Primary cutaneous aspergillosis at the site of cyanoacrylate skin adhesive in a neonate

Kusari

Sprague

Eichenfield

et al. 2018

Pediatric Dermatology

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Primary cutaneous aspergillosis is a rare but potentially life-threatening disease. We present the case of a premature infant who developed primary cutaneous aspergillosis with Aspergillus niger at the site of a skin abrasion that had been treated with a purple-colored cyanoacrylate product. The infection was treated successfully with gentle debridement of the cyanoacrylate product, followed by intravenous voriconazole and topical fluconazole. To our knowledge, this is the first reported case of primary cutaneous aspergillosis occurring at the site of cyanoacrylate-based skin adhesive.

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“…Despite a number of reported complications associated with their use such as embolism and needle impaction [10], cyanoacrylate has been reported to have higher hemostasis and lower rebleeding rates than traditional band ligation and sclerotherapy in gastroesophageal varices [2]. Moreover, they have been reported to have antibiotic activity towards gram-positive bacteria [11].…”

Section: Introductionmentioning

confidence: 99%

Risk of rebleeding from gastroesophageal varices after initial treatment with cyanoacrylate; a systematic review and pooled analysis

Zhang

Swai

et al. 2020

BMC Gastroenterol

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Background: Cyanoacrylate alone or in combination with other interventions, can be used to achieve variable rates of success in preventing rebleeding. Our study aims to assess the pooled risk of gastric and esophageal varices rebleeding after an initial treatment with cyanoacrylate alone and/or in combination with other treatments, by a systematic review of the literature and pooled analysis. Methods: PubMed, EMBASE, SCOPUS, and the Cochrane library were searched for studies that reported the risk of rebleeding during the follow-up period after treatment of gastric or esophageal varices with either cyanoacrylate alone or in combination with other treatments. Standard error, upper and lower confidence intervals at 95% confidence interval for the risk were obtained using STATA Version 15 which was also used to generate forest plots for pooled analysis. The random or fixed effect model was applied depending on the heterogeneity (I 2). Results: A total of 39 studies were found to report treatment of either gastric or esophageal varices with either cyanoacrylate alone or in combination with other treatments. When gastric varices are treated with cyanoacrylate alone, the risk of rebleeding during the follow-up period is 0.15(Confidence Interval: 0.11-0.18). When combined with lipiodol; polidocanol or sclerotherapy the rebleeding risks are 0.13 (

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The antibacterial effect of 2-octyl cyanoacrylate (Dermabond®) skin adhesive

Cited by 75 publications

References 27 publications

Structural Analysis and Application of n‐Alkyl Cyanoacrylate Surgical Adhesives to the Fixation of Meshes for Hernia Repair

Structural Analysis and Application of n‐Alkyl Cyanoacrylate Surgical Adhesives to the Fixation of Meshes for Hernia Repair

Primary cutaneous aspergillosis at the site of cyanoacrylate skin adhesive in a neonate

Risk of rebleeding from gastroesophageal varices after initial treatment with cyanoacrylate; a systematic review and pooled analysis

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