The Antibiofilm Effect of Blueberry Fruit Cultivars Against<i>Staphylococcus epidermidis</i>and<i>Pseudomonas aeruginosa</i>

“…; Donlan ; Zimmer et al . ). An interesting phenomena registered in the antibiofilm assay was the fact that for four of the micro‐organisms tested, E. coli R, Ps.…”

Section: Discussionmentioning

confidence: 97%

Antimicrobial, antiadhesive and antibiofilm activity of an ethanolic, anthocyanin-rich blueberry extract purified by solid phase extraction

et al. 2016

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“…[ 29 ]. Chlorogenic acid extracted from blueberry fruit was able to inhibit 46% and 42% of S. epidermidis and P. aeruginosa biofilm formation, respectively [ 30 ]. We believe that the phenolic acids present in WGJe played an important role in reducing biofilm formation of E. coli and P. aeruginosa , in a dose-dependent way.…”

Section: Discussionmentioning

confidence: 99%

In VitroAntimicrobial Activity and Effect on Biofilm Production of a White Grape Juice (Vitis vinifera) Extract

Filocamo

Bisignano

Mandalari

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Background. The aim of the present study was to evaluate the antimicrobial effect of a white grape juice extract (WGJe) against a range of Gram-positive and Gram-negative bacteria, yeasts, and the fungus Aspergillus niger. WGJe was also tested on the production of bacterial biofilms in vitro. Results. WGJe inhibited in vitro most Gram-positive bacteria tested, Staphylococcus aureus ATCC 6538P being the most sensitive strain (MIC values of 3.9 μg/mL). The effect was bactericidal at the concentration of 500 μg/mL. Amongst the Gram-negative bacteria, Escherichia coli was the only susceptible strain (MIC and MBC of 2000 μg/mL). No effect on the growth of Candida sp. and the fungus Aspergillus niger was detected (MIC values > 2000 μg/mL). WGJe inhibited the biofilms formation of E. coli and Pseudomonas aeruginosa with a dose-dependent effect. Conclusions. WGJe exerted both bacteriostatic and bactericidal activity in vitro. The presented results could be used to develop novel strategies for the treatment of skin infections and against potential respiratory pathogens.

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“…Macrophages and monocytes are 37 the first line of host defence against bacterial infections and play a key role in the 38 initiation of an adaptive immune response 7 . These cells secrete many cytokines, 39 including tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-40 6), and interleukin-8 (CXCL8), in response to stimulation by periodontopathogens such 41 as F. nucleatum [8][9] . While this host response is often involved in gingival tissue Proper nutrition may be very important in the management of periodontal diseases 19 .…”

Section: Introductionmentioning

confidence: 99%

Wild Blueberry (Vaccinium angustifolium Ait.) Polyphenols Target Fusobacterium nucleatum and the Host Inflammatory Response: Potential Innovative Molecules for Treating Periodontal Diseases

Lagha

Dudonné

Desjardins

et al. 2015

J. Agric. Food Chem.

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Blueberries contain significant amounts of flavonoids to which a number of beneficial health effects in humans have been associated. The present study investigated the effect of a polyphenol-rich lowbush blueberry (Vaccinium angustifolium Ait.) extract on the two main etiologic components of periodontitis, a multifactorial disorder affecting the supporting structures of the teeth. Phenolic acids, flavonoids (flavonols, anthocyanins, flavan-3-ols), and procyanidins made up 16.6, 12.9, and 2.7% of the blueberry extract, respectively. The blueberry extract showed antibacterial activity (MIC = 1 mg/mL) against the periodontopathogenic bacterium Fusobacterium nucleatum. This property may result from the ability of blueberry polyphenols to chelate iron. Moreover, the blueberry extract at 62.5 μg/mL inhibited F. nucleatum biofilm formation by 87.5 ± 2.3%. Subsequently, the ability of the blueberry extract to inhibit the NF-κB signaling pathway in U937-3xκB cells was investigated. The blueberry extract dose-dependently inhibited the activation of NF-κB induced by F. nucleatum. In addition, a pretreatment of macrophages with the blueberry extract (62.5 μg/mL) inhibited the secretion of IL-1β, TNF-α, and IL-6 by 87.3 ± 1.3, 80.7 ± 5.6, and 28.2 ± 9.3%, respectively, following a stimulation with F. nucleatum. Similarly, the secretion of MMP-8 and MMP-9 was also dose-dependently inhibited. This dual antibacterial and anti-inflammatory action of lowbush blueberry polyphenols suggests that they may be promising candidates for novel therapeutic agents.

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The Antibiofilm Effect of Blueberry Fruit Cultivars AgainstStaphylococcus epidermidisandPseudomonas aeruginosa

Cited by 25 publications

References 30 publications

Antimicrobial, antiadhesive and antibiofilm activity of an ethanolic, anthocyanin-rich blueberry extract purified by solid phase extraction

Antimicrobial, antiadhesive and antibiofilm activity of an ethanolic, anthocyanin-rich blueberry extract purified by solid phase extraction

In VitroAntimicrobial Activity and Effect on Biofilm Production of a White Grape Juice (Vitis vinifera) Extract

Wild Blueberry (Vaccinium angustifolium Ait.) Polyphenols Target Fusobacterium nucleatum and the Host Inflammatory Response: Potential Innovative Molecules for Treating Periodontal Diseases

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