The Anticancer Efficacy of Platinum Azidothymidin on Hepatocellular Carcinoma Via Affecting the Telomerase and the BcL-2 Genes Expression

Telomerase reactivation is associated with hepatobiliary and pancreatic cancers

“…Furthermore, it is interesting to note that some drugs, such as Azidothymidin [51] and PI3K δ inhibitors [52] , despite not appearing to have a direct effect on TERT, have shown promising results in murine models, also presenting a reduction of TERT activity itself. It is therefore important to understand the involvement of TERT in the carcinogenesis pathway of HCC, given the pivotal role that it seems to have, with a subsequent therapeutic potential.…”